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Mediating intracellular communication

Mediating intracellular communication © 1994 Nature Publishing Group http://www.nature.com/nsmb editorial Mediating intracellular communication Being able to respond to the G-protein because of its requirement for environment is vital for all GTP. Indeed, the nature of the interaction cells, be they free- living uni­ between the rod -cell G-protein transducin cellular organisms or the and its cytoplasmic effector is explored in constituents of tissues that a paper from Margolskee and colleagues in make up multicellular plants and animals. this issue • Indeed, there are suggestions that the 2.5 billion years it took for multicellular organ­ G-proteins isms to appear may have been related to the There are three characterized classes of cell­ need to develop the complex signalling surface receptor proteins: those linked to mechanisms that allowed intercellular com­ ion channels, enzymes and G-proteins. The munication and the coordination of cellu­ last group of receptors, which typically have lar behaviour. A mere twenty years ago the a seven-helix transmembrane structure, is nature of these cellular information high­ by far the largest, its members being num­ ways was, for the most part, a black box. bered in the hundreds. Cellular responses Since then a vast effort has been directed to an extensive range of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Structural & Molecular Biology Springer Journals

Mediating intracellular communication

Nature Structural & Molecular Biology , Volume 1 (11) – Nov 1, 1994
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Publisher
Springer Journals
Copyright
Copyright © 1994 by Nature Publishing Group
Subject
Life Sciences; Life Sciences, general; Biochemistry, general; Protein Structure; Membrane Biology; Biological Microscopy
ISSN
1545-9993
eISSN
1545-9985
DOI
10.1038/nsb1194-747
Publisher site
See Article on Publisher Site

Abstract

© 1994 Nature Publishing Group http://www.nature.com/nsmb editorial Mediating intracellular communication Being able to respond to the G-protein because of its requirement for environment is vital for all GTP. Indeed, the nature of the interaction cells, be they free- living uni­ between the rod -cell G-protein transducin cellular organisms or the and its cytoplasmic effector is explored in constituents of tissues that a paper from Margolskee and colleagues in make up multicellular plants and animals. this issue • Indeed, there are suggestions that the 2.5 billion years it took for multicellular organ­ G-proteins isms to appear may have been related to the There are three characterized classes of cell­ need to develop the complex signalling surface receptor proteins: those linked to mechanisms that allowed intercellular com­ ion channels, enzymes and G-proteins. The munication and the coordination of cellu­ last group of receptors, which typically have lar behaviour. A mere twenty years ago the a seven-helix transmembrane structure, is nature of these cellular information high­ by far the largest, its members being num­ ways was, for the most part, a black box. bered in the hundreds. Cellular responses Since then a vast effort has been directed to an extensive range of

Journal

Nature Structural & Molecular Biology – Springer Journals

Published: Nov 1, 1994

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