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- Publisher
- Wiley
- Copyright
- Copyright © 1984 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 0001-6314
- eISSN
- 1600-0404
- DOI
- 10.1111/j.1600-0404.1984.tb07774.x
- Publisher site
- See Article on Publisher Site
Abstract
ABSTRACT— 35 patients with a mean seizure frequency of 15 attacks per months were studied. 19 were taking a 2‐drug combination, 13 a 3‐drug combination and 3 patients a 4‐drug combination. Treatment was reduced to monotherapy in 21 patients and to a 2‐drug combination in 8 patients. There was an increase in seizure frequency in 6 patients taking a 2‐drug combination when an attempt was made to reduce the treatment to monotherapy. Reduction in polypharmacy resulted in an improvement in seizure control in 54% of patients. Carbamazine replaced polypharmacy as monotherapy in 19 patients and phenytoin and sodium valproate in 2 other patients. Improvement in seizure control was associated with optimal blood levels in 17 patients taking carbamazepine and in the 2 patients taking sodium valproate and phenytoin. Serum levels in all patients taking 2‐drug combination were within the optimal range.
Journal
Acta Neurologica Scandinavica – Wiley
Published: Jan 1, 1984