Abstract

ORGANIC PREPARATIONS AND PROCEDURES I", 27 (2), 179-184 (1995) PERFORMANCE FLUIDS AS AN INERT MEDIUM FOR THE PREPARATION OF BENZOTRIAZOLE DERNATMS Alan R. Katritzky*, Dorin Toader and Jinlong Jiang Center for Heterocyclic Compounds, Deparlment of Chemistry Universiry of Flo& Gainesville, FL 3261 1-7200 Organic reactions can be carried out either in the presence or absence of a solvent. An important reason for using a solvent is to limit the reaction temperature to its boiling point. If reactions are heated without a solvent for a prolonged period, two problems often arise: (0 the reaction compo- nents are more easily oxidized in the absence of the protection provided by the solvent vapor; (ii) the desired constant reaction temperature is sometimes difficult to maintain. Recently, Zhu reported the use of perfluorocarbon (PFC) fluids (performance fluids) as the inert medium for ester transforma- tions as well as for acetal, ketal and enamine syntheses.' Performance fluids provide a novel medium in which the substrates react as though in the absence of solvent, but the reaction proceeds as though in the presence of solvent with respect to maintenance of temperature and protection by the solvent vapor. We now report that some benzotriazole derivatives are conveniently