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Using empirically-derived dimensional phenotypes to accelerate clinical neuroscience: the Hierarchical Taxonomy of Psychopathology (HiTOP) framework

Using empirically-derived dimensional phenotypes to accelerate clinical neuroscience: the... www.nature.com/npp PERSPECTIVE Using empirically-derived dimensional phenotypes to accelerate clinical neuroscience: the Hierarchical Taxonomy of Psychopathology (HiTOP) framework 1 2 Robert D. Latzman , Colin G. DeYoung and The HiTOP Neurobiological Foundations Workgroup Neuropsychopharmacology (2020) 45:1083–1085; https://doi.org/10.1038/s41386-020-0639-6 Clinical neuroscience seeks to understand the neurobiological the full range of psychopathology (Fig. 1)[2]. At the top levels of mechanisms of mental illness and translate that knowledge into the HiTOP hierarchy are broad dimensional spectra and super- effective, biologically-informed interventions, including pharma- spectra, including an overarching general psychopathology cological approaches. The past two decades have witnessed the dimension that reflects broad liability to diverse forms of development of powerful new tools for quantifying variation in psychopathology situated lower in the hierarchy. The internalizing the human brain. Nonetheless, although substantial resources and spectrum, for example, encompasses more specific subfactors efforts have been invested in identifying reliable neurobiological including fear and distress, which, in turn, encompass even indicators of mental illness, or “biomarkers”, only modest progress narrower clinical phenotypes (e.g., social anxiety, insomnia). has been made. A growing consensus attributes this lack of Researchers are thus able to test relations with neurobiological progress largely to the shortcomings of current categorical mechanisms at multiple levels of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuropsychopharmacology Springer Journals

Using empirically-derived dimensional phenotypes to accelerate clinical neuroscience: the Hierarchical Taxonomy of Psychopathology (HiTOP) framework

Latzman, Robert D.; DeYoung, Colin G.; ,
Neuropsychopharmacology , Volume 45 (7) – Jun 28, 2020
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References (7)

Publisher
Springer Journals
Copyright
Copyright © American College of Neuropsychopharmacology 2020
ISSN
0893-133X
eISSN
1740-634X
DOI
10.1038/s41386-020-0639-6
Publisher site
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Abstract

www.nature.com/npp PERSPECTIVE Using empirically-derived dimensional phenotypes to accelerate clinical neuroscience: the Hierarchical Taxonomy of Psychopathology (HiTOP) framework 1 2 Robert D. Latzman , Colin G. DeYoung and The HiTOP Neurobiological Foundations Workgroup Neuropsychopharmacology (2020) 45:1083–1085; https://doi.org/10.1038/s41386-020-0639-6 Clinical neuroscience seeks to understand the neurobiological the full range of psychopathology (Fig. 1)[2]. At the top levels of mechanisms of mental illness and translate that knowledge into the HiTOP hierarchy are broad dimensional spectra and super- effective, biologically-informed interventions, including pharma- spectra, including an overarching general psychopathology cological approaches. The past two decades have witnessed the dimension that reflects broad liability to diverse forms of development of powerful new tools for quantifying variation in psychopathology situated lower in the hierarchy. The internalizing the human brain. Nonetheless, although substantial resources and spectrum, for example, encompasses more specific subfactors efforts have been invested in identifying reliable neurobiological including fear and distress, which, in turn, encompass even indicators of mental illness, or “biomarkers”, only modest progress narrower clinical phenotypes (e.g., social anxiety, insomnia). has been made. A growing consensus attributes this lack of Researchers are thus able to test relations with neurobiological progress largely to the shortcomings of current categorical mechanisms at multiple levels of

Journal

Neuropsychopharmacology – Springer Journals

Published: Jun 28, 2020

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