Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence

The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence Downloaded from genesdev.cshlp.org on September 23, 2021 - Published by Cold Spring Harbor Laboratory Press RESEARCH COMMUNICATION Lowe 2001). On the other hand, oncogenic ras does not The DNA damage signaling induce p53 via ARF in human fibroblasts and, as a con- sequence, ARF is not required for ras-induced senescence pathway is a critical mediator in these cells (Wei et al. 2001). ARF was also dispensable of oncogene-induced for p53 activation and apoptosis after Rb inactivation and E2F induction in mice (Tolbert et al. 2002). Other senescence candidates connecting oncogenic ras to p53 are the p38 mitogen-activated protein kinase (MAPK) pathway Frédérick A. Mallette, (Deng et al. 2004), PML protein (Ferbeyre et al. 2000; Marie-France Gaumont-Leclerc, Pearson et al. 2000), PEA-15 (Gaumont-Leclerc et al. and Gerardo Ferbeyre 2004), and seladin (Wu et al. 2004). In summary, multiple signaling pathways seem to connect RasV12 to p53, and Département de Biochimie, Université de Montréal, Montréal, no unique sensor of oncogenic activity has yet emerged Québec H3C 3J7, Canada from these studies. To investigate the nature of the signals that activate Here we report that RNA interference against ATM in- the p53 pathway during senescence, we thought that it hibited p53 accumulation http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genes & Development Unpaywall

The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence

Download PDF
7 pages

Loading next page...
 
/lp/unpaywall/the-dna-damage-signaling-pathway-is-a-critical-mediator-of-oncogene-IdHrFAB7ee

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Unpaywall
ISSN
0890-9369
DOI
10.1101/gad.1487307
Publisher site
See Article on Publisher Site

Abstract

Downloaded from genesdev.cshlp.org on September 23, 2021 - Published by Cold Spring Harbor Laboratory Press RESEARCH COMMUNICATION Lowe 2001). On the other hand, oncogenic ras does not The DNA damage signaling induce p53 via ARF in human fibroblasts and, as a con- sequence, ARF is not required for ras-induced senescence pathway is a critical mediator in these cells (Wei et al. 2001). ARF was also dispensable of oncogene-induced for p53 activation and apoptosis after Rb inactivation and E2F induction in mice (Tolbert et al. 2002). Other senescence candidates connecting oncogenic ras to p53 are the p38 mitogen-activated protein kinase (MAPK) pathway Frédérick A. Mallette, (Deng et al. 2004), PML protein (Ferbeyre et al. 2000; Marie-France Gaumont-Leclerc, Pearson et al. 2000), PEA-15 (Gaumont-Leclerc et al. and Gerardo Ferbeyre 2004), and seladin (Wu et al. 2004). In summary, multiple signaling pathways seem to connect RasV12 to p53, and Département de Biochimie, Université de Montréal, Montréal, no unique sensor of oncogenic activity has yet emerged Québec H3C 3J7, Canada from these studies. To investigate the nature of the signals that activate Here we report that RNA interference against ATM in- the p53 pathway during senescence, we thought that it hibited p53 accumulation

Journal

Genes & Development – Unpaywall

Published: Jan 1, 2007

There are no references for this article.