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Disruption of the gene encoding the latent transforming growth factor-β binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer

Disruption of the gene encoding the latent transforming growth factor-β binding protein 4... Downloaded from genesdev.cshlp.org on November 23, 2021 - Published by Cold Spring Harbor Laboratory Press Disruption of the gene encoding the latent transforming growth factor- binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer 1,5 1,5 3 1 1 Anja Sterner-Kock, Irmgard S. Thorey, Katri Koli, Frank Wempe, Jürgen Otte, 1 1 4 1,2 3 Thorsten Bangsow, Katharina Kuhlmeier, Thomas Kirchner, Shenchu Jin, Jorma Keski-Oja, 1,6 and Harald von Melchner 1 2 Laboratory for Molecular Hematology and Department of Pharmacology, University of Frankfurt Medical School, 60596 Frankfurt am Main, Germany; Departments of Virology and Pathology, Haartman Institute and Helsinki University Hospital, University of Helsinki, 00014 Helsinki, Finland; Department of Pathology, University of Erlangen-Nürnberg, 91054 Erlangen, Germany Transforming growth factor-s (TGF-s) are multifunctional growth factors that are secreted as inactive (latent) precursors in large protein complexes. These complexes include the latency-associated propeptide (LAP) and a latent transforming growth factor- binding protein (LTBP). Four isoforms of LTBPs (LTBP-1–LTBP-4) have been cloned and are believed to be structural components of connective tissue microfibrils and local regulators of TGF- tissue deposition and signaling. By using a gene trap strategy that selects for integrations into genes induced transiently during early mouse http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genes & Development Unpaywall

Disruption of the gene encoding the latent transforming growth factor-β binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer

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Unpaywall
ISSN
0890-9369
DOI
10.1101/gad.229102
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Abstract

Downloaded from genesdev.cshlp.org on November 23, 2021 - Published by Cold Spring Harbor Laboratory Press Disruption of the gene encoding the latent transforming growth factor- binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer 1,5 1,5 3 1 1 Anja Sterner-Kock, Irmgard S. Thorey, Katri Koli, Frank Wempe, Jürgen Otte, 1 1 4 1,2 3 Thorsten Bangsow, Katharina Kuhlmeier, Thomas Kirchner, Shenchu Jin, Jorma Keski-Oja, 1,6 and Harald von Melchner 1 2 Laboratory for Molecular Hematology and Department of Pharmacology, University of Frankfurt Medical School, 60596 Frankfurt am Main, Germany; Departments of Virology and Pathology, Haartman Institute and Helsinki University Hospital, University of Helsinki, 00014 Helsinki, Finland; Department of Pathology, University of Erlangen-Nürnberg, 91054 Erlangen, Germany Transforming growth factor-s (TGF-s) are multifunctional growth factors that are secreted as inactive (latent) precursors in large protein complexes. These complexes include the latency-associated propeptide (LAP) and a latent transforming growth factor- binding protein (LTBP). Four isoforms of LTBPs (LTBP-1–LTBP-4) have been cloned and are believed to be structural components of connective tissue microfibrils and local regulators of TGF- tissue deposition and signaling. By using a gene trap strategy that selects for integrations into genes induced transiently during early mouse

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Genes & Development – Unpaywall

Published: Sep 1, 2002

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