Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/a-matrix-metalloproteinase-expressed-on-the-surface-of-invasive-tumour-J7WaqxpC48
References (28)
-
I. Collier, S. Wilhelm, A. Eisen, B. Marmer, G. Grant, J. Seltzer, A. Kronberger, C. He, E. Bauer, G. Goldberg (1988)
H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.The Journal of biological chemistry, 263 14
-
P. Brown, R. Bloxidge, N. Stuart, Kevin Galler, J. Carmichael (1993)
Association between expression of activated 72-kilodalton gelatinase and tumor spread in non-small-cell lung carcinoma.Journal of the National Cancer Institute, 85 7
-
J. Woessner (1991)
Matrix metalloproteinases and their inhibitors in connective tissue remodelingThe FASEB Journal, 5
-
S. Wilhelm, I. Collier, B. Marmer, A. Eisen, G. Grant, G. Goldberg (1989)
SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages.The Journal of biological chemistry, 264 29
-
Hala Azzam, Erik Thompson (1992)
Collagen-induced activation of the M(r) 72,000 type IV collagenase in normal and malignant human fibroblastoid cells.Cancer research, 52 16
-
C. Heussen, E. Dowdle (1980)
Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates.Analytical biochemistry, 102 1
-
Y. Okada, T. Morodomi, J. Enghild, Ko Suzuki, A. Yasui, Isao Nakanishi, G. Salvesen, H. Nagase (1990)
Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties.European journal of biochemistry, 194 3
-
A. Albini, Yukihide Iwamoto, H. Kleinman, G. Martin, S. Aaronson, Kozlowski Jm, R. McEwan (1987)
A rapid in vitro assay for quantitating the invasive potential of tumor cells.Cancer research, 47 12
-
Weiping Jiang, J. Bond (1992)
Families of metalloendopeptidases and their relationshipsFEBS Letters, 312
-
P. Basset, J. Bellocq, C. Wolf, I. Stoll, P. Hutin, J. Limacher, O. Podhajcer, Chenard Mp, M. Rio, P. Chambon (1990)
A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomasNature, 348
-
A. Strongin, B. Marmer, G. Grant, G. Goldberg (1993)
Plasma membrane-dependent activation of the 72-kDa type IV collagenase is prevented by complex formation with TIMP-2.The Journal of biological chemistry, 268 19
-
H. Birkedal‐Hansen, W. Moore, M. Bodden, L. Windsor, B. Birkedal‐Hansen, A. Decarlo, J. Engler (1993)
Matrix metalloproteinases: a review.Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists, 4 2
-
L. Liotta, P. Steeg, W. Stetler-Stevenson (1991)
Cancer metastasis and angiogenesis: An imbalance of positive and negative regulationCell, 64
-
L. Matrisian (1990)
Metalloproteinases and their inhibitors in matrix remodeling.Trends in genetics : TIG, 6 4
-
C. Overall, J. Sodek (1990)
Concanavalin A produces a matrix-degradative phenotype in human fibroblasts. Induction and endogenous activation of collagenase, 72-kDa gelatinase, and Pump-1 is accompanied by the suppression of the tissue inhibitor of matrix metalloproteinases.The Journal of biological chemistry, 265 34
-
Y. Tsuchiya, Hiroshi Sato, Yoshio Endo, Yasunori Okada, M. Mai, Takuma Sasaki, Motoharu Seiki (1993)
Tissue inhibitor of metalloproteinase 1 is a negative regulator of the metastatic ability of a human gastric cancer cell line, KKLS, in the chick embryo.Cancer research, 53 6
-
D. Kleiner, W. Stetler-Stevenson (1993)
Structural biochemistry and activation of matrix metalloproteases.Current opinion in cell biology, 5 5
-
R. Ward, S. Atkinson, P. Slocombe, A. Docherty, J. Reynolds, Gillian Murphy (1991)
Tissue inhibitor of metalloproteinases-2 inhibits the activation of 72 kDa progelatinase by fibroblast membranes.Biochimica et biophysica acta, 1079 2
-
P. Brown, D. Kleiner, E. Unsworth, W. Stetler-Stevenson (1993)
Cellular activation of the 72 kDa type IV procollagenase/TIMP-2 complex.Kidney international, 43 1
-
W. Stetler-Stevenson, S. Aznavoorian, L. Liotta (1993)
Tumor cell interactions with the extracellular matrix during invasion and metastasis.Annual review of cell biology, 9
-
S. Whitham, G. Murphy, P. Angel, H. Rahmsdorf, B. Smith, A. Lyons, T. Harris, J. Reynolds, P. Herrlich, A. Docherty (1986)
Comparison of human stromelysin and collagenase by cloning and sequence analysis.The Biochemical journal, 240 3
-
Hala Azzam, G. Arand, M. Lippman, Erik Thompson (1993)
Association of MMP-2 activation potential with metastatic progression in human breast cancer cell lines independent of MMP-2 production.Journal of the National Cancer Institute, 85 21
-
H. Wart, Henning BIRKEDAL-HANSENt (1990)
The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.Proceedings of the National Academy of Sciences of the United States of America, 87
-
N. Templeton, P. Brown, A. Levy, I. Margulies, L. Liotta, W. Stetler-Stevenson (1990)
Cloning and characterization of human tumor cell interstitial collagenase.Cancer research, 50 17
-
Masahiro Hosaka, Masami Nagahama, Won Kim, Tsuyoshi Watanabe, K. Hatsuzawa, J. Ikemizu, Kazuo Murakami, Kazuhisa Nakayama (1991)
Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway.The Journal of biological chemistry, 266 19
-
L. Matrisian, Bowden Gt (1990)
Stromelysin/transin and tumor progression.Seminars in cancer biology, 1 2
-
R. Poulsom, M. Pignatelli, M. Pignatelli, W. Stetler-Stevenson, L. Liotta, Patricia Wright, R. Jeffery, J. Longcroft, L. Rogers, G. Stamp, G. Stamp (1992)
Stromal expression of 72 kda type IV collagenase (MMP-2) and TIMP-2 mRNAs in colorectal neoplasia.The American journal of pathology, 141 2
-
P. Brown, A. Levy, I. Margulies, L. Liotta, W. Stetler-Stevenson (1990)
Independent expression and cellular processing of Mr 72,000 type IV collagenase and interstitial collagenase in human tumorigenic cell lines.Cancer research, 50 19
- Publisher
- Springer Journals
- Copyright
- Copyright © 1994 by Nature Publishing Group
- Subject
- Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
- ISSN
- 0028-0836
- eISSN
- 1476-4687
- DOI
- 10.1038/370061a0
- Publisher site
- See Article on Publisher Site
Abstract
GELATINASE A (type-IV collagenase; Mr 72,000) is produced by tumour stroma cells and is believed to be crucial for their invasion and metastasis, acting by degrading extracellular matrix macro-molecules such as type IV collagen1–3. An inactive precursor of gelatinase A (pro-gelatinase A) is secreted and activated in invasive tumour tissue4–7 as a result of proteolysis which is mediated by a fraction of tumour cell membrane that is sensitive to metallopro-teinase inhibitors4,5. Here we report the cloning of the complemen-tary DNA encoding a new matrix metalloproteinase with a potential transmembrane domain. Expression of the gene product on the cell surface induces specific activation of pro-gelatinase A in vitro and enhances cellular invasion of the reconstituted basement membrane. Tumour cells of invasive lung carcinomas, which con-tain activated forms of gelatinase A, were found to express the transcript and the gene product. The new metalloproteinase may thus trigger invasion by tumour cells by activating pro-gelatinase A on the tumour cell surface.
Journal
Nature – Springer Journals
Published: Jul 7, 1994