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Induced fit in RNA–protein recognition

Induced fit in RNA–protein recognition Two generalizations can be drawn from the recent rapid progress in understanding RNA–protein interactions. First, there is a great diversity of observed protein and RNA structural motifs. Second, formation of almost every RNA–protein complex that has been characterized involves conformational changes in the protein, the RNA, or both. The role of these conformational changes in the biological function of RNA–protein complexes is not at all clear. Whether or not conformational changes are a critical feature of ribonucleoprotein complex assembly or are an unimportant mechanistic detail, the ubiquity of these changes warrants careful consideration of their implications. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Structural & Molecular Biology Springer Journals

Induced fit in RNA–protein recognition

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References (35)

Publisher
Springer Journals
Copyright
Copyright © 2000 by Nature America Inc.
Subject
Life Sciences; Life Sciences, general; Biochemistry, general; Protein Structure; Membrane Biology; Biological Microscopy
ISSN
1545-9993
eISSN
1545-9985
DOI
10.1038/79575
Publisher site
See Article on Publisher Site

Abstract

Two generalizations can be drawn from the recent rapid progress in understanding RNA–protein interactions. First, there is a great diversity of observed protein and RNA structural motifs. Second, formation of almost every RNA–protein complex that has been characterized involves conformational changes in the protein, the RNA, or both. The role of these conformational changes in the biological function of RNA–protein complexes is not at all clear. Whether or not conformational changes are a critical feature of ribonucleoprotein complex assembly or are an unimportant mechanistic detail, the ubiquity of these changes warrants careful consideration of their implications.

Journal

Nature Structural & Molecular BiologySpringer Journals

Published: Oct 1, 2000

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