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Association of the interleukin‐1 gene cluster with radiographic signs of osteoarthritis of the hip

Association of the interleukin‐1 gene cluster with radiographic signs of osteoarthritis of the hip Objective To study the role of the interleukin‐1β gene (IL1B) and the IL‐1 receptor antagonist gene (IL1RN) in relation to the occurrence of radiographic osteoarthritis (ROA) in the hip, knee, and hand and disc degeneration of the spine. Methods The study population consisted of a random sample of 886 subjects (ages 55–65 years) from a population‐based cohort (the Rotterdam study). Two polymorphisms within IL1B (3953C>T and −511C>T) and one within IL1RN (the variable‐number tandem repeat (VNTR)) were analyzed and used in an association study of the occurrence of ROA. Haplotyping and simultaneous logistic regression analysis were performed to investigate whether the associations observed were independent. Results Associations with a predisposition for hip ROA were observed for heterozygous and homozygous carriers of the rare IL1B allele −511T (crude odds ratio (OR) 1.8, 95% confidence interval (95% CI) 1.0–3.4 and OR 2.9, 95% CI 1.4–6.3, respectively) and of the IL1RN VNTR allele 2 (crude OR 2.0, 95% CI 1.1–3.4 and OR 3.3, 95% CI 1.4–7.8, respectively). An additive effect was observed for carriers of risk alleles of both polymorphisms, with a significant linear‐by‐linear association (P = 0.00022). Conclusion Our findings suggest that the IL‐1 gene cluster polymorphisms may play a significant role in the pathogenesis of OA of the hip. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arthritis & Rheumatism Wiley

Association of the interleukin‐1 gene cluster with radiographic signs of osteoarthritis of the hip

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References (38)

Publisher
Wiley
Copyright
Copyright © 2004 by the American College of Rheumatology
ISSN
0004-3591
eISSN
1529-0131
DOI
10.1002/art.20121
pmid
15077300
Publisher site
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Abstract

Objective To study the role of the interleukin‐1β gene (IL1B) and the IL‐1 receptor antagonist gene (IL1RN) in relation to the occurrence of radiographic osteoarthritis (ROA) in the hip, knee, and hand and disc degeneration of the spine. Methods The study population consisted of a random sample of 886 subjects (ages 55–65 years) from a population‐based cohort (the Rotterdam study). Two polymorphisms within IL1B (3953C>T and −511C>T) and one within IL1RN (the variable‐number tandem repeat (VNTR)) were analyzed and used in an association study of the occurrence of ROA. Haplotyping and simultaneous logistic regression analysis were performed to investigate whether the associations observed were independent. Results Associations with a predisposition for hip ROA were observed for heterozygous and homozygous carriers of the rare IL1B allele −511T (crude odds ratio (OR) 1.8, 95% confidence interval (95% CI) 1.0–3.4 and OR 2.9, 95% CI 1.4–6.3, respectively) and of the IL1RN VNTR allele 2 (crude OR 2.0, 95% CI 1.1–3.4 and OR 3.3, 95% CI 1.4–7.8, respectively). An additive effect was observed for carriers of risk alleles of both polymorphisms, with a significant linear‐by‐linear association (P = 0.00022). Conclusion Our findings suggest that the IL‐1 gene cluster polymorphisms may play a significant role in the pathogenesis of OA of the hip.

Journal

Arthritis & Rheumatism – Wiley

Published: Apr 1, 2004

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