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- Publisher
- Rockefeller University Press
- Copyright
- © 1994 Rockefeller University Press
- ISSN
- 0022-1007
- eISSN
- 1540-9538
- DOI
- 10.1084/jem.179.3.1047
- Publisher site
- See Article on Publisher Site
Abstract
Neutrophils, the most common inflammatory leukocytes, have the most limited life span of all blood cells. After they undergo apoptosis, they are recognized and engulfed by macrophages. bcl-2, a proto-oncogene rearranged and deregulated in B cell lymphomas bearing the t(14;18) translocation, is known to inhibit programmed death. bcl-2 expression is localized in early myeloid cells of the bone marrow but is absent in mature neutrophils. Transgenic mice that expressed bcl-2 in mature neutrophils showed that bcl-2 blocked neutrophil apoptosis. Despite this, homeostasis of neutrophil population is essentially unaffected. In fact, macrophage uptake of neutrophils expressing bcl-2 still occurred. This transgenic model indicates that the mechanism that triggers phagocytosis of aging neutrophils operates independently of the process of apoptosis regulated by bcl-2.
Journal
The Journal of Experimental Medicine – Rockefeller University Press
Published: Mar 1, 1994