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- Publisher
- Oxford University Press
- Copyright
- © American Society of Clinical Pathologists
- ISSN
- 0002-9173
- eISSN
- 1943-7722
- DOI
- 10.1093/ajcp/90.4.385
- Publisher site
- See Article on Publisher Site
Abstract
The value of HMB-45 mouse monoclonal antibody in the immunohistochemical diagnosis of melanoma was compared with that of two antibodies to S-100 protein. Tissue from 32 (91.4%) of the 35 melanomas studied reacted with HMB-45, however, none of the 98 nonmelanoma tumors stained with this antibody. In contrast, 31 (88.5%) melanomas and 24 (24.4%) of the nonmelanoma neoplasms expressed S-100 protein. These results indicated that HMB-45 monoclonal antibody has a higher specificity for melanoma cells than did S-100 protein and that, because of its reactivity in routinely processed tissues, it may be helpful in surgical pathology.
Journal
American Journal of Clinical Pathology – Oxford University Press
Published: Oct 1, 1988