/lp/wiley/inhibition-of-k-secretion-in-the-distal-nephron-in-nephrotic-syndrome-KImBUPGRSb
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- Publisher
- Wiley
- Copyright
- © 2011 The Authors. Journal compilation © 2011 The Physiological Society
- ISSN
- 0022-3751
- eISSN
- 1469-7793
- DOI
- 10.1113/jphysiol.2011.209692
- pmid
- 21606114
- Publisher site
- See Article on Publisher Site
Abstract
Non‐technical summary Plasma potassium concentration is a major determinant of muscle contractility and nerve conduction. The maintenance of plasma potassium concentration depends on the ability of kidneys to daily secrete in the urine the exact quantity of potassium ingested in the food. We show that in nephrotic syndrome, a common disease featuring abnormal urinary protein excretion and sodium retention, the membrane protein called ROMK channel responsible for kidney potassium secretion is inhibited. Thus, nephrotic rats are unable to excrete a dietary load of potassium and develop hyperkalaemia. Based on these findings, we would recommend not only a low sodium diet but also a controlled potassium diet for patients with nephrotic syndrome.
Journal
The Journal of Physiology – Wiley
Published: Jul 15, 2011