Access the full text.
Sign up today, get DeepDyve free for 14 days.
Yoriko Saito, Hitomi Yuki, M. Kuratani, Yoshinobu Hashizume, S. Takagi, T. Honma, A. Tanaka, M. Shirouzu, J. Mikuni, N. Handa, Ikuko Ogahara, Akiko Sone, Y. Najima, Y. Tomabechi, M. Wakiyama, N. Uchida, Mariko Tomizawa-Murasawa, Akiko Kaneko, Satoshi Tanaka, Nahoko Suzuki, H. Kajita, Y. Aoki, O. Ohara, L. Shultz, T. Fukami, T. Goto, S. Taniguchi, S. Yokoyama, F. Ishikawa (2013)
A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in VivoScience Translational Medicine, 5
M. Malim, M. Emerman (2008)
HIV-1 accessory proteins--ensuring viral survival in a hostile environment.Cell host & microbe, 3 6
T. Pene-Dumitrescu, T. Smithgall (2010)
Expression of a Src Family Kinase in Chronic Myelogenous Leukemia Cells Induces Resistance to Imatinib in a Kinase-dependent Manner*The Journal of Biological Chemistry, 285
E. Lerner, T. Smithgall (2002)
SH3-dependent stimulation of Src-family kinase autophosphorylation without tail release from the SH2 domain in vivoNature Structural Biology, 9
J. Hochrein, E. Lerner, A. Schiavone, T. Smithgall, J. Engen (2006)
An examination of dynamics crosstalk between SH2 and SH3 domains by hydrogen/deuterium exchange and mass spectrometryProtein Science, 15
Matthew Martin, J. Newcomb, J. Nunes, Jean Bemis, David McGowan, Ryan White, J. Buchanan, E. DiMauro, C. Boucher, Theodore Faust, Faye Hsieh, Xin Huang, J. Lee, Steve Schneider, S. Turci, Xiaotian Zhu (2007)
Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: synthesis, SAR, and pharmacokinetic properties.Bioorganic & medicinal chemistry letters, 17 8
M. LaFevre-Bernt, F. Sicheri, Alexander Pico, M. Porter, J. Kuriyan, W. Miller (1998)
Intramolecular Regulatory Interactions in the Src Family Kinase Hck Probed by Mutagenesis of a Conserved Tryptophan Residue*The Journal of Biological Chemistry, 273
Jamie Moroco, J. Craigo, Roxana Iacob, T. Wales, J. Engen, T. Smithgall (2014)
Differential Sensitivity of Src-Family Kinases to Activation by SH3 Domain DisplacementPLoS ONE, 9
F. Sicheri, I. Moarefi, J. Kuriyan (1997)
Crystal structure of the Src family tyrosine kinase HckNature, 385
S. Briggs, M. Sharkey, M. Stevenson, T. Smithgall (1997)
SH3-mediated Hck Tyrosine Kinase Activation and Fibroblast Transformation by the Nef Protein of HIV-1*The Journal of Biological Chemistry, 272
J. Engen (1999)
Analysis of unfolding and protein dynamics in the regulatory domains of hematopoietic cell kinase with hydrogen exchange and mass spectrometry
T. Pene-Dumitrescu, S. Shu, T. Wales, J. Alvarado, Haibin Shi, P. Narute, Jamie Moroco, Joanne Yeh, J. Engen, T. Smithgall (2012)
HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, HckBMC Chemical Biology, 12
J. Alvarado, Sreya Tarafdar, Joanne Yeh, T. Smithgall (2014)
Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment*The Journal of Biological Chemistry, 289
K. Saksela (2011)
Interactions of the HIV/SIV pathogenicity factor Nef with SH3 domain-containing host cell proteins.Current HIV research, 9 7
Zhongqi Zhang, David Smith (1993)
Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidationProtein Science, 2
I. Moarefi, M. LaFevre-Bernt, F. Sicheri, M. Huse, Chi-Hon Lee, J. Kuriyan, W. Miller (1997)
Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacementNature, 385
R. Trible, Lori Emert-Sedlak, T. Smithgall (2006)
HIV-1 Nef Selectively Activates Src Family Kinases Hck, Lyn, and c-Src through Direct SH3 Domain Interaction*Journal of Biological Chemistry, 281
J. Hochrein, T. Wales, E. Lerner, A. Schiavone, T. Smithgall, J. Engen (2006)
Conformational features of the full-length HIV and SIV Nef proteins determined by mass spectrometry.Biochemistry, 45 25
J. Alvarado, L. Betts, Jamie Moroco, T. Smithgall, Joanne Yeh (2010)
Crystal Structure of the Src Family Kinase Hck SH3-SH2 Linker Regulatory Region Supports an SH3-dominant Activation Mechanism*The Journal of Biological Chemistry, 285
C. Hung, L. Thomas, Carl Ruby, K. Atkins, N. Morris, Z. Knight, Isabel Scholz, E. Barklis, A. Weinberg, K. Shokat, G. Thomas (2007)
HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I.Cell host & microbe, 1 2
M. Meyn, Matthew Wilson, Fadi Abdi, Nathalie Fahey, A. Schiavone, Jiong Wu, J. Hochrein, J. Engen, T. Smithgall (2006)
Src Family Kinases Phosphorylate the Bcr-Abl SH3-SH2 Region and Modulate Bcr-Abl Transforming Activity*Journal of Biological Chemistry, 281
Lori Emert-Sedlak, T. Kodama, E. Lerner, Weixiang Dai, C. Foster, B. Day, J. Lazo, T. Smithgall (2009)
Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds.ACS chemical biology, 4 11
Wenqing Xu, S. Harrison, M. Eck (1997)
Three-dimensional structure of the tyrosine kinase c-SrcNature, 385
H. Yamaguchi, W. Hendrickson (1996)
Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylationNature, 384
T. Schindler, F. Sicheri, Alexander Pico, A. Gazit, A. Levitzki, J. Kuriyan, J. Kuriyan (1999)
Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor.Molecular cell, 3 5
M. Porter, Thomas Schindler, John Kuriyan, W. Miller (2000)
Reciprocal regulation of Hck activity by phosphorylation of Tyr(527) and Tyr(416). Effect of introducing a high affinity intramolecular SH2 ligand.The Journal of biological chemistry, 275 4
J. Engen, W. Gmeiner, T. Smithgall, David Smith (1999)
Hydrogen exchange shows peptide binding stabilizes motions in Hck SH2.Biochemistry, 38 28
Lori Emert-Sedlak, P. Narute, S. Shu, Jerrod Poe, Haibin Shi, N. Yanamala, J. Alvarado, J. Lazo, Joanne Yeh, P. Johnston, T. Smithgall (2013)
Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity.Chemistry & biology, 20 1
P. Narute, T. Smithgall (2012)
Nef Alleles from All Major HIV-1 Clades Activate Src-Family Kinases and Enhance HIV-1 Replication in an Inhibitor-Sensitive MannerPLoS ONE, 7
R. Guiet, Renaud Poincloux, J. Castandet, L. Marois, A. Labrousse, V. Cabec, I. Maridonneau-Parini (2008)
Hematopoietic cell kinase (Hck) isoforms and phagocyte duties - from signaling and actin reorganization to migration and phagocytosis.European journal of cell biology, 87 8-9
Y. Chong, Kim Ia, T. Mulhern, Heung-Chin Cheng (2005)
Endogenous and synthetic inhibitors of the Src-family protein tyrosine kinases.Biochimica et biophysica acta, 1754 1-2
D. Weis, J. Engen, Ignatius Kass (2006)
Semi-automated data processing of hydrogen exchange mass spectra using HX-ExpressJournal of The American Society for Mass Spectrometry, 17
T. Pene-Dumitrescu, L. Peterson, N. Donato, T. Smithgall (2008)
An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259Oncogene, 27
Roxana Iacob, J. Engen (2012)
Hydrogen Exchange Mass Spectrometry: Are We Out of the Quicksand?Journal of The American Society for Mass Spectrometry, 23
J. Engen, T. Wales, Shugui Chen, E. Marzluff, Kerry Hassell, D. Weis, T. Smithgall (2013)
Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometryInternational Reviews in Physical Chemistry, 32
T. Smithgall, G. Thomas (2013)
Small molecule inhibitors of the HIV-1 virulence factor, Nef.Drug discovery today. Technologies, 10 4
J. Dikeakos, K. Atkins, L. Thomas, Lori Emert-Sedlak, I. Byeon, Jinwon Jung, Jinwoo Ahn, M. Wortman, Benjamin Kukull, M. Saito, Hirokazu Koizumi, Danielle Williamson, M. Hiyoshi, E. Barklis, M. Takiguchi, S. Suzu, A. Gronenborn, T. Smithgall, G. Thomas (2010)
Small Molecule Inhibition of HIV-1–Induced MHC-I Down-Regulation Identifies a Temporally Regulated Switch in Nef ActionMolecular Biology of the Cell, 21
E. Lerner, R. Trible, A. Schiavone, J. Hochrein, J. Engen, T. Smithgall (2005)
Activation of the Src Family Kinase Hck without SH3-Linker Release*Journal of Biological Chemistry, 280
Lintao Wang, Hai Pan, David Smith (2002)
Hydrogen Exchange-Mass SpectrometryMolecular & Cellular Proteomics, 1
R. Trible, P. Narute, Lori Emert-Sedlak, J. Alvarado, K. Atkins, L. Thomas, T. Kodama, N. Yanamala, V. Korotchenko, B. Day, G. Thomas, T. Smithgall (2013)
Discovery of a diaminoquinoxaline benzenesulfonamide antagonist of HIV-1 Nef function using a yeast-based phenotypic screenRetrovirology, 10
Wenqing Xu, A. Doshi, M. Lei, M. Eck, S. Harrison, S. Harrison (1999)
Crystal structures of c-Src reveal features of its autoinhibitory mechanism.Molecular cell, 3 5
T. Wales, Keith Fadgen, G. Gerhardt, J. Engen (2008)
High-speed and high-resolution UPLC separation at zero degrees Celsius.Analytical chemistry, 80 17
Biochemistry – Unpaywall
Published: Oct 6, 2015
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.