Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/the-prohance-story-the-making-of-a-novel-mri-contrast-agent-KS0HoHHDnu
References (29)
-
Krishan Kumar, C. Chang, M. Tweedle (1993)
Equilibrium and Kinetic Studies of Lanthanide Complexes of Macrocyclic Polyamino CarboxylatesInorganic Chemistry, 32
-
P. Wedeking, K. Kumar, M. Tweedle (1992)
Dissociation of gadolinium chelates in mice: relationship to chemical characteristics.Magnetic resonance imaging, 10 4
-
M. Tweedle, J. Hagan, K. Kumar, S. Mantha, C. Chang (1991)
Reaction of gadolinium chelates with endogenously available ions.Magnetic resonance imaging, 9 3
-
J. Hagan, S. Taylor, M. Tweedle (1988)
Fluorescence detection of gadolinium chelates separated by reversed-phase high-performance liquid chromatographyAnalytical Chemistry, 60
-
(1992)
Kinetic investigations of the lanthanide DOTA chelates -
A. Nordenbo, F. Somnier (1992)
Acute deterioration of myasthenia gravis after intravenous administration of gadolinium-DTPAThe Lancet, 340
-
P. Wedeking, M. Tweedle (1988)
Comparison of the biodistribution of 153Gd-labeled Gd(DTPA)2-, Gd(DOTA)-, and Gd(acetate)n in mice.International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 15 4
-
T. Masui, Y. Takehara, R. Aoshima, M. Kaneko (1994)
Acute hemodynamic effects of nonionic and ionic magnetic resonance contrast media in intravenous bolus injection in rats.Investigative radiology, 29 Suppl 2
-
H. Gries, H. Miklautz (1984)
Some physicochemical properties of the gadolinium-DTPA complex, a contrast agent for MRI.Physiological chemistry and physics and medical NMR, 16 2
-
(1996)
Ion speciation in blood plasma: gallium-67-citrate and MRI contrast agents -
(1994)
Determination of free Gd3 + as a CDTA complex by reversed-phase HPLC in ionic gadolinium (III) chelates -
Krishan Kumar, C. Chang, L. Francesconi, D. Dischino, M. Malley, J. Gougoutas, M. Tweedle (1994)
Synthesis, stability, and structure of gadolinium(III) and yttrium(III) macrocyclic poly(amino carboxylates)Inorganic Chemistry, 33
-
(1980)
NMR spectroscopy of lanthanide complexes with a tetraacetic tetraaza macrocycle. Unusual conformation properties -
Lisbeth Ehnebom, B. Pedersen, W. Lyttle, N. Brese, Å. Oskarsson, D. Carcanague, I. Chao, K. Houk (1992)
Molecular and Crystal Structure of a Lanthanide Complex, DyDTPA--BMA Hydrate.Acta Chemica Scandinavica, 46
-
M. Tweedle (1991)
Nonionic or neutral?Radiology, 178 3
-
Chia-Ting Chang, L. Francesconi, M. Malley, Krishan Kumar, J. Gougoutas, M. Tweedle, Dongwon Lee, L. Wilson (1993)
Synthesis, characterization, and crystal structures of M(DO3A) (M = Fe, Gd) and Na[M(DOTA)] (M = Fe, Y, Gd)Inorganic Chemistry, 32
-
T. Kasokat, K. Urich (1992)
Quantification of dechelation of gadopentetate dimeglumine in rats.Arzneimittel-Forschung, 42 6
-
J. Wiggins, H. Goldstein, H. Weinmann (1991)
Gallium-67/stable gadolinium antagonism.Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 32 9
-
(1996)
Human in vivo comparative study of zinc and copper transmetallation following administration of MRI contrast agents -
(1989)
Relaxation agents in NMR imaging. In: Bunzli JCG, Choppin GR (eds) Lanthanide probes in life chemical and earth sciences -
Michael Ibrahim, V. Haughton, James Hyde (1994)
Enhancement of intervertebral disks with gadolinium complexes: comparison of an ionic and a nonionic medium in an animal model.AJNR. American journal of neuroradiology, 15 10
-
B. Biagi, J. Enyeart (1990)
Gadolinium blocks low- and high-threshold calcium currents in pituitary cells.The American journal of physiology, 259 3 Pt 1
-
(1991)
Extravascular toxicity of two mr contrast agents -
(1980)
Synthesis of nonionic gadolinium chelates useful as contrast agents in magnetic resonance imaging -
Xun Zhang, C. Chang, H. Brittain, J. Garrison, J. Telser, M. Tweedle (1990)
pH dependence of relaxivities and hydration numbers of gadolinium(III) complexes of macrocyclic amino carboxylatesInorganic Chemistry, 29
-
J. Molgó, E. Pozo, J. Baños, D. Angaut-Petit (1991)
Changes of quantal transmitter release caused by gadolinium ions at the frog neuromuscular junctionBritish Journal of Pharmacology, 104
-
C. Corot, A. Hentsch, L. Curtelin (1994)
Interaction of gadolinium complexes with metal-dependent biological systems.Investigative radiology, 29 Suppl 2
-
W. Cacheris, Steve Quay, S. Rocklage (1990)
The relationship between thermodynamics and the toxicity of gadolinium complexes.Magnetic resonance imaging, 8 4
-
M. Tweedle, P. Wedeking, K. Kumar (1995)
Biodistribution of Radiolabeled, Formulated Gadopentetate, Gadoteridol, Gadoterate, and Gadodiamide in Mice and RatsInvestigative Radiology, 30
- Publisher
- Springer Journals
- Copyright
- Copyright © 1997 by Springer-Verlag Berlin Heidelberg
- Subject
- Medicine & Public Health; Imaging / Radiology; Diagnostic Radiology; Interventional Radiology; Neuroradiology; Ultrasound; Internal Medicine
- ISSN
- 0938-7994
- eISSN
- 1432-1084
- DOI
- 10.1007/PL00006897
- Publisher site
- See Article on Publisher Site
Abstract
The four gadolinium chelates currently in clinical use as magnetic resonance imaging (MRI) contrast agents differ in two structural features: linear vs. macrocyclic cores, and ionic vs. nonionic charge types. While all are equivalent in relaxation effectiveness, the nonionic molecules have lower osmolality and viscosity and may be formulated safely at greater concentrations, and delivered confidently at greater doses and as a faster bolus. The macrocyclic molecules are more stable and show less tendency to dissociate free Gd. ProHance was conceived well over a decade ago, based upon a unique structure. It was first marketed in the USA in 1992, and was the first nonionic agent. It remains today still the only commercial MRI agent that is both macrocyclic and nonionic. To date it has been used safely in over a million patients.
Journal
European Radiology – Springer Journals
Published: Nov 27, 1997