Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/oxford-university-press/accumulation-of-manganese-in-rat-brain-following-intranasal-KivDjPWaX1
References (15)
-
D. Perl, P. Good (1987)
UPTAKE OF ALUMINIUM INTO CENTRAL NERVOUS SYSTEM ALONG NASAL-OLFACTORY PATHWAYSThe Lancet, 329
-
D. Paynter (1979)
Microdetermination of manganese in animal tissues by flameless atomic absorption spectrometry.Analytical chemistry, 51 13
-
Grahame-Smith Dg (1984)
Catecholamine toxicity : a proposal for the molecular pathogenesis of manganese neurotoxicity and Parkinson's diseaseNeurotoxicology, 5
-
Bird Ed, Anton Ah, B. Bullock (1984)
The effect of manganese inhalation on basal ganglia dopamine concentrations in rhesus monkey.Neurotoxicology, 5 1
-
Richard Clay, John Morris (1989)
Comparative pneumotoxicity of cyclopentadienyl manganese tricarbonyl and methylcyclopentadienyl manganese tricarbonyl.Toxicology and applied pharmacology, 98 3
-
J. Evans, L. Hastings (1992)
Accumulation of Cd(II) in the CNS depending on the route of administration: intraperitoneal, intratracheal, or intranasal.Fundamental and applied toxicology : official journal of the Society of Toxicology, 19 2
-
A. Asbury, G. Mckhann, W. Mcdonald (1992)
Diseases of the Nervous System: Clinical Neurobiology -
Moroccan Miners, J. Rodier (1955)
Manganese Poisoning in Moroccan MinersBritish Journal of Industrial Medicine, 12
-
L. Hastings, J. Evans (1991)
Olfactory primary neurons as a route of entry for toxic agents into the CNS.Neurotoxicology, 12 4
-
I. Mena, O. Marin, S. Fuenzalida, G. Cotzias (1967)
Chronic manganese poisoningNeurology, 17
-
G. Cotzias, P. Papavasiliou, I. Mena, L. Tang, S. Miller (1974)
Manganese and catecholamines.Advances in neurology, 5
-
Morganti Jb, Lown Ba, Stineman Ch, Ralph D'Agostino, Massaro Ej (1985)
Uptake, distribution and behavioral effects of inhalation exposure to manganese (MnO2) in the adult mouse.Neurotoxicology, 6 1
-
R. Ingersoll, ERWIN Montgomery, H. Aposhian (1995)
Central nervous system toxicity of manganese. I. Inhibition of spontaneous motor activity in rats after intrathecal administration of manganese chloride.Fundamental and applied toxicology : official journal of the Society of Toxicology, 27 1
-
M. Clair, E. Gross, K. Morgan (1990)
Pathology and Cell Proliferation Induced by Intra-nasal Instillation of Aldehydes in the Rat: Comparison of Glutaraldehyde and FormaldehydeToxicologic Pathology, 18
-
Wei Zheng, D. Perry, D. Nelson, H. Aposhian (1991)
Choroid plexus protects cerebrospinal fluid against toxic metalsThe FASEB Journal, 5
- Publisher
- Oxford University Press
- Copyright
- © 1997 by the Society of Toxicology
- ISSN
- 1096-6080
- eISSN
- 1096-0929
- DOI
- 10.1093/toxsci/37.2.102
- Publisher site
- See Article on Publisher Site
Abstract
Abstract Manganese chloride (50–800 μg) was injected unilaterally into the right nostril of rats and its accumulation in the central nervous system (CNS) was monitored. Brain manganese levels were elevated in a dose-dependent, time-dependent, and tissue-dependent manner. Elevated levels of manganese were detected in the right olfactory bulb and olfactory tubercle within 12 hr after instillation and remained elevated for at least 3 days. As little as 100 μg of manganese chloride was sufficient to increase brain manganese levels. No changes were detected on the left side of the brain. The manganese content of the striatum, the target site for manganese neurotoxicity, was unchanged following acute administration, but was elevated when two injections were made 1 week apart. These results suggest that air-borne manganese can be retrogradely transported along olfactory neurons to the CNS and can reach deeper brain structures under appropriate exposure conditions. © 1997 by the Society of Toxicology
Journal
Toxicological Sciences – Oxford University Press
Published: Jun 1, 1997