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Corticosteroid levels in human fetal blood at midgestation and at term.

Corticosteroid levels in human fetal blood at midgestation and at term. Cortisol and cortisone were estimated in samples of fetal blood obtained by fetoscopy at 13 to 24 weeks' gestation and in cord blood obtained at elective cesarean section at 38 weeks' gestation. Levels of cortisone exceeded those of cortisol at all gestational ages studied. At midgestation, cortisol levels tended to fall with advancing gestation and had a weak negative correlation with fetal weight. The levels of both steroids were similar in male and female fetuses and increased significantly from midgestation to term. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of obstetrics and gynecology Pubmed

Corticosteroid levels in human fetal blood at midgestation and at term.

López Bernal, A; MacKenzie, I Z
American journal of obstetrics and gynecology , Volume 156 (1): -108 – Feb 17, 1987
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Corticosteroid levels in human fetal blood at midgestation and at term.


Abstract

Cortisol and cortisone were estimated in samples of fetal blood obtained by fetoscopy at 13 to 24 weeks' gestation and in cord blood obtained at elective cesarean section at 38 weeks' gestation. Levels of cortisone exceeded those of cortisol at all gestational ages studied. At midgestation, cortisol levels tended to fall with advancing gestation and had a weak negative correlation with fetal weight. The levels of both steroids were similar in male and female fetuses and increased significantly from midgestation to term.

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ISSN
0002-9378
DOI
10.1016/0002-9378(87)90217-1
pmid
3799743

Abstract

Cortisol and cortisone were estimated in samples of fetal blood obtained by fetoscopy at 13 to 24 weeks' gestation and in cord blood obtained at elective cesarean section at 38 weeks' gestation. Levels of cortisone exceeded those of cortisol at all gestational ages studied. At midgestation, cortisol levels tended to fall with advancing gestation and had a weak negative correlation with fetal weight. The levels of both steroids were similar in male and female fetuses and increased significantly from midgestation to term.

Journal

American journal of obstetrics and gynecology – Pubmed

Published: Feb 17, 1987

References

  • Human serum cortisol levels related to gestational age: evidence of a midgestational fall and a steep late gestational rise independent of sex or mode of delivery
    Murphy
  • Pure fetal blood from the umbilical cord obtained at fetoscopy: experience with 125 consecutive cases
    MacKenzie
  • Cortisol: cortisone interconversion by human decidua in relation to parturition. Effect of tissue manipulation on 11β-hydroxysteroid dehydrogenase activity
    López Bernal
  • Steroid production by definitive and fetal zones of the human fetal adrenal gland
    Seron-Ferre
  • Transcortin, a corticosteroid binding globulin in plasma. X. Cortisol and progesterone interplay and unbound levels of free steroids in pregnancy
    Rosenthal
  • Concentrations of aldosterone, corticosterone, 11-deoxycorticosterone, progesterone, 17-hydroxyprogesterone, 11-deoxycortisol, cortisol and cortisone determined simultaneously in human amniotic fluid throughout gestation
    Sippel
  • 11β-Hydroxysteroid dehydrogenase activity of the human placenta during pregnanc
    Blasco