Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/wolters-kluwer-health/high-incidence-of-adh2-1-aldh2-1-genes-among-japanese-alcohol-KubL5YQqRT
References (57)
-
S Harada, DP Agarwal, HW Goedde (1985)
Aldehyde dehydrogenase and alcohol metabolism in alcoholics, 2
-
Y Xu, LG Carr, WF Bosron, TK Li, HJ Edenberg (1988)
Genotyping of human alcohol dehydrogenase at the ADH2 and ADH3 loci following DNA sequence amplification, 2
-
(1985)
ADH2*1/*1, and even a small Acad Sci U S A 1985;82:2703-2707. amount of acetaldehyde produced in these cases -
P Couzigou, B Fleury, A Groppi, A Cassaigne, J Begueret, A Iron (1990)
Genotyping study of alcohol dehydrogenase class I polymorphism in French patients with alcohol cirrhosis, 25
-
(1981)
phisms at the alcohol and aldehyde dehydrogenase loci in genetic predisposition to alcohol-related end-organ damage -
WF Bosron, L Lumeng, TK Li (1988)
Genetic polymorphism of enzymes of alcohol metabolism and susceptibility to alcohol liver disease, 10
-
(1985)
metabolism in alcoholics -
(1991)
Alcohol andterminating inhibitors -
(1983)
Isolation and charatypical human livers -
(1994)
difference in peak acetaldehyde lev- 1994;106:1085-1105. els nor alcohol elimination rates between heterozygous -
Nobuyuki Enomoto, S. Takase, M. Yasuhara, A. Takada (1991)
Acetaldehyde metabolism in different aldehyde dehydrogenase-2 genotypes.Alcoholism, clinical and experimental research, 15 1
-
M. Yasunami, I. Kikuchi, D. Sarapata, A. Yoshida (1990)
The human class I alcohol dehydrogenase gene cluster: three genes are tandemly organized in an 80-kb-long segment of the genome.Genomics, 7 2
-
CP Day, R Bashir, OFW James, MF Bassendine, DW Crabb, HR Thomasson, TK Li (1991)
Investigation of the role of polymorphisms at the alcohol and aldehyde dehydrogenase loci in genetic predisposition to alcohol‐related end‐organ damage, 14
-
Furthermore, the present study clearly showed that 2 -
Aldehyde dehydrogenase be quickly metabolized into acetate by active subunit and -
H Jornvall, J Hempel, BL Vallee, WF Bosron, TK Li (1984)
Human liver alcohol dehydrogenase: amino acid substitution of the beta 2 beta 2 oriental isozyme explains functional properties, establishes an active situ structure, and parallels mutational exchanges in the yeast enzyme, 81
-
T Ikuta, T Fujiyosi, K Kurachi, A Yoshida (1985)
Molecular cloning of a full‐length cDNA for human alcohol dehydrogenase, 82
-
DW Crabb, HJ Edenberg, WF Bosron, TK Li (1989)
Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity, 83
-
F Vidal, J Perez, J Panisello, R Toda, C Gutierrez, C Richart (1993)
Atypical liver alcohol dehydrogenase in the Spanish population: its relation with the development of alcoholic liver disease, 17
-
D. Sherman, R. Ward, M. Warren-Perry, R. Williams, T. Peters (1993)
Association of restriction fragment length polymorphism in alcohol dehydrogenase 2 gene with alcohol induced liver damage.British Medical Journal, 307
-
(1988)
Polymorphism of alcohol dehydrogenase genes and alcoholicfollowing DNA sequence amplification -
H Thomasson, HJ Edenberg, DW Crabb, XL Mai, RE Jerome, TK Li, SP Wang (1991)
Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese, 48
-
(1988)
Genotyping study of alcohol dehydrogenase class I polymor - ( ALDH 21 ) with the disease -
WF Bosron, T Ehrig, TK Li (1993)
Genetic factors in alcohol metabolism and alcoholism, 13
-
QL Choo, G Kuo, AJ Weiner (1989)
Isolation of a cDNA clone derived from a blood‐born non‐A, non‐B virus hepatitis genome, 244
-
CS Lieber (1994)
Alcohol and the liver: 1994 update, 106
-
(1989)
Chromosomal assignment of alcohol hybridization -
A Shibuya, A Yoshida (1988)
Genotypes of alcohol‐metabolizing enzymes in Japanese with alcohol liver disease: a strong association of the usual Caucasian‐type aldehyde dehydrogenase gene (ALDH21) with the disease, 43
-
(1989)
Polymorphism of aldehyde dehydrogenase and its ap-Because high concentration of serum acetaldehyde is plication to alcoholism -
T Ehrig, WF Bosron, TK Li (1990)
Alcohol and acetaldehyde dehydrogenase, 25
-
YC Chao, SR Liou, YY Chung, HS Tang, CT Hsu, TK Li, SJ Yin (1994)
Polymorphism of alcohol dehydrogenase genes and alcoholic cirrhosis in Chinese patients, 19
-
(1990)
Diagnostic and statistical phism in French patients with alcohol cirrhosis -
Y. Mizoi, Kenji Yamamoto, Y. Ueno, Tatsushige Fukunagai, S. Harada (1994)
Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenases in individual variation of alcohol metabolism.Alcohol and alcoholism, 29 6
-
David Crabb, H. Edenberg, W. Bosron, Ting-Kai Li (1989)
Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant.The Journal of clinical investigation, 83 1
-
M. Fisher, J. Rankin (1977)
Alcohol and the LiverRevista Clinica Espanola, 131
-
(1991)
DNA sequencing with chain- 1991;48:677-681 -
HR Thomasson, DW Crabb, HJ Edenberg, TK Li (1993)
Alcohol and acetaldehyde dehydrogenase polymorphisms and alcoholism, 23
-
Genetic factors in alcohol metabo - tients . 27 , 28 lism and alcoholism -
W. Bosron, Ting-kai Li (1986)
Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholismHepatology, 6
-
(1992)
Isolation of a cDNA clone derivedties of ADH 3 genes -
(1989)
from a blood-born non-A, non-B virus hepatitis genome -
(1985)
Molecular cloning ofbe increased immediately after ingesting alcohol in the a full - length cDNA for human alcohol dehydrogenase -
M Tsukahara, A Yoshida (1989)
Chromosomal assignment of alcohol dehydrogenase cluster locus to human chromosome 4q 21–23 by in situ hybridization, 4
-
N Enomoto, S Takase, N Takada, A Takada (1991)
Alcoholic liver disease in heterozygotes of mutant and normal aldehyde dehydrogenase‐2 genes, 13
-
Thus, acetaldehyde levels in se-1984 -
Human ity of the ADH in a person presenting homozygous liver alcohol dehydrogenase: amino acid substitution of the beta 2 beta 2 oriental isozyme explains functional properties -
M Ikawa, CC Impraim, G Wang, A Yoshida (1983)
Isolation and characterization of aldehyde dehydrogenase isoenzymes from usual and atypical human livers, 258
-
(1990)
Alcohol and acetaldehyde dehydro - alcoholics when compared with controls . Even in terms genase -
Cloning of cDNA for human aldehyde dehydrogenase 1 and 2 -
A Shibuya, M Yasunami, A Yoshida (1989)
Genotype of alcohol dehydrogenase and aldehyde dehydrogenase loci in Japanese alcohol flushers and non‐flushers, 82
-
F. Tanaka, M. Omata, O. Yokosuka, Y. Tsukada, M. Ohto (1992)
Determination of nucleotide sequence of active site for catalytic properties of ADH3 genes.Biochemical and biophysical research communications, 184 2
-
An Group (1981)
ALCOHOLIC LIVER DISEASE: MORPHOLOGICAL MANIFESTATIONSThe Lancet, 317
-
S Harada (1989)
Polymorphism of aldehyde dehydrogenase and its application to alcoholism, 10
-
F Sanger, S Nicklen, AR Coulson (1977)
DNA sequencing with chain‐terminating inhibitors, 74
-
(1988)
Genotypes of alcohol-metabolizing enzymes in Japanese with alcohol liver disease: a strong associa-18-96 17:18:22 hepa WBS: Hepatology tion of the usual Caucasian-type aldehyde dehydrogenase gene 24 -
Mizoi et al. 30 reported 13. Lieber CS. Alcohol and the liver: 1994 update. Gastroenterology that there was no difference in peak acetaldehyde lev-1994 -
(1980)
Diagnostic and statistical manual of mental disorders
- Publisher
- Wolters Kluwer Health
- Copyright
- Copyright © 1996 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 0270-9139
- eISSN
- 1527-3350
- DOI
- 10.1002/hep.510230206
- Publisher site
- See Article on Publisher Site
Abstract
In an attempt to clarify the genetic factors in alcoholism among the Japanese, polymorphism of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) genes has been investigated. Genetic polymorphism of ADH2/ALDH2 in 66 cases of normal subjects, 90 cases of alcohol dependent, and 31 patients with alcoholic liver disease among Japanese has been analyzed using a polymerase chain reaction assay followed by a direct sequencing method, because ethanol is mainly catabolized by ADH and ALDH and less by cytochrome P450IIE1 and catalase. The incidence of both ADH2*1/*1 and ALDH2*1/*1 was significantly higher in patients with alcohol dependence and in patients with alcoholic liver disease when compared with that in control subjects. In addition, the incidence of ALDH2*1/*2 and ALDH2*2/*2 was significantly reduced in alcoholics compared with control subjects. Genetic polymorphism of ADH2/ALDH2 in patients with alcoholic liver disease was not different from that of alcohol dependents. According to these results, not only ALDH2 gene, often claimed to be responsible for alcohol dependence among Japanese, but also ADH2 gene polymorphism, which modulates the metabolism of ethanol, play important roles in habitual alcohol intake behavior in Japanese patients and in some patients leads to alcoholic liver diseases.
Journal
Hepatology – Wolters Kluwer Health
Published: Feb 1, 1996