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References (99)
-
Yosef Gruenbaum, Yosef Landesman, B. Drees, John Bare, Harald Saumweber, M. Paddy, J. Sedat, David Smith, Bret Benton, Paul Fisher (1988)
Drosophila nuclear lamin precursor Dm0 is translated from either of two developmentally regulated mRNA species apparently encoded by a single gene [published erratum appears in J Cell Biol 1988 Jun;106(6):2225]The Journal of Cell Biology, 106
-
L. Beck, T. Hosick, M. Sinensky (1988)
Incorporation of a product of mevalonic acid metabolism into proteins of Chinese hamster ovary cell nucleiThe Journal of Cell Biology, 107
-
P. Ma, G. Gil, T. Südhof, D. Bilheimer, J. Goldstein, Michael Brown (1986)
Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits.Proceedings of the National Academy of Sciences of the United States of America, 83 21
-
V. Quesney-Huneeus, M. Wiley, M. Siperstein (1979)
Essential role for mevalonate synthesis in DNA replication.Proceedings of the National Academy of Sciences of the United States of America, 76 10
-
Monty Krieger, Joseph Goldstein, Michael Brown (1978)
Receptor-mediated uptake of low density lipoprotein reconstituted with 25-hydroxycholesteryl oleate suppresses 3-hydroxy-3-methylglutaryl-coenzyme A reductase and inhibits growth of human fibroblasts.Proceedings of the National Academy of Sciences of the United States of America, 75 10
-
H. Dohlman, M. Caron, R. Lefkowitz (1987)
A family of receptors coupled to guanine nucleotide regulatory proteins.Biochemistry, 26 10
-
A Endo (1988)
10.1007/BF01745510Klin. Wschr., 66
-
ME Basson (1988)
10.1128/MCB.8.9.3797Molec. cell. Biol., 8
-
J. Kadonaga, K. Jones, R. Tjian (1986)
Promoter-specific activation of RNA polymerase II transcription by Sp1Trends in Biochemical Sciences, 11
-
C. Santoro, N. Mermod, P. Andrews, R. Tjian (1988)
A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAsNature, 334
-
T. Südhof, J. Goldstein, Michael Brown, D. Russell (1985)
The LDL receptor gene: a mosaic of exons shared with different proteins.Science, 228 4701
-
D. Chin, K. Luskey, R. Anderson, J. Faust, J. Goldstein, Michael Brown (1982)
Appearance of crystalloid endoplasmic reticulum in compactin-resistant Chinese hamster cells with a 500-fold increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase.Proceedings of the National Academy of Sciences of the United States of America, 79 4
-
T. Südhof, D. Westhuyzen, J. Goldstein, Michael Brown, D. Russell (1987)
Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene.The Journal of biological chemistry, 262 22
-
S. Leonard, M. Sinensky (1988)
Somatic cell genetics and the study of cholesterol metabolism.Biochimica et biophysica acta, 947 1
-
G. Gil, J. Smith, J. Goldstein, M. Brown (1987)
Optional exon in the 5'-untranslated region of 3-hydroxy-3-methylglutaryl coenzyme A synthase gene: conserved sequence and splicing pattern in humans and hamsters.Proceedings of the National Academy of Sciences of the United States of America, 84 7
-
JE Metherall (1989)
10.1016/S0021-9258(19)84879-2J. biol. Chem., 264
-
MS Brown (1980)
10.1016/S0022-2275(20)42221-7J. Lipid Res., 21
-
R. Hall (1970)
N6-(δ2-Isopentenyl)adenosine: Chemical Reactions, Biosynthesis, Metabolism, and Significance to the Structure and Function of †RNAProgress in Nucleic Acid Research and Molecular Biology, 10
-
G. Gil, Michael Brown, J. Goldstein (1986)
Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase from the hamster. II. Isolation of the gene and characterization of the 5' flanking region.The Journal of biological chemistry, 261 8
-
G. Gil, J. Smith, J. Goldstein, C. Slaughter, K. Orth, M. Brown, T. Osborne (1988)
Multiple genes encode nuclear factor 1-like proteins that bind to the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase.Proceedings of the National Academy of Sciences of the United States of America, 85 23
-
P. Dawson, N. Ridgway, C. Slaughter, M. Brown, J. Goldstein (1989)
cDNA cloning and expression of oxysterol-binding protein, an oligomer with a potential leucine zipper.The Journal of biological chemistry, 264 28
-
James Metherall, J. Goldstein, K. Luskey, M. Brown (1989)
Loss of transcriptional repression of three sterol-regulated genes in mutant hamster cells.The Journal of biological chemistry, 264 26
-
P. Melançon, B. Glick, V. Malhotra, P. Weidman, T. Serafini, M. Gleason, L. Orci, J. Rothman (1987)
Involvement of GTP-binding “G” proteins in transport through the Golgi stackCell, 51
-
CC Farnsworth (1989)
10.1016/S0021-9258(19)47079-8J. biol. Chem., 264
-
T. Südhof, D. Russell, Michael Brown, J. Goldstein (1987)
42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoterCell, 48
-
W. Schafer, R. Kim, Rachel Sterne, J. Thorner, Sung-Hou Kim, J. Rine (1989)
Genetic and pharmacological suppression of oncogenic mutations in ras genes of yeast and humans.Science, 245 4916
-
M. Nakanishi, J. Goldstein, Michael Brown (1988)
Multivalent control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme.The Journal of biological chemistry, 263 18
-
L. Gutiérrez, A. Magee, C. Marshall, J. Hancock (1989)
Post‐translational processing of p21ras is two‐step and involves carboxyl‐methylation and carboxy‐terminal proteolysis.The EMBO Journal, 8
-
V. Rodwell, J. Nordstrom, J. Mitschelen (1976)
Regulation of HMG-CoA reductase.Advances in lipid research, 14
-
Y. Kamiya, A. Sakurai, S. Tamura, N. Takahashi, K. Abe, E. Tsuchiya, S. Fukui, C. Kitada, M. Fujino (1978)
Structure of rhodotorucine A, a novel lipopeptide, inducing mating tube formation in Rhodosporidium toruloides.Biochemical and biophysical research communications, 83 3
-
D. Skalnik, H. Narita, C. Kent, R. Simoni (1988)
The membrane domain of 3-hydroxy-3-methylglutaryl-coenzyme A reductase confers endoplasmic reticulum localization and sterol-regulated degradation onto beta-galactosidase.The Journal of biological chemistry, 263 14
-
D. Chin, G. Gil, D. Russell, L. Liscum, K. Luskey, S. Basu, H. Okayama, P. Berg, J. Goldstein, Michael Brown (1984)
Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulumNature, 308
-
G Gil (1986)
10.1016/S0021-9258(17)35706-XJ. biol. Chem., 261
-
Y. Sakagami, M. Yoshida, A. Isogai, A. Suzuki (1981)
Peptidal Sex Hormones Inducing Conjugation Tube Formation in Compatible Mating-Type Cells of Tremella mesenterica.Science, 212 4502
-
Hisato Jingami, Michael Brown, Joseph Goldstein, Richard Anderson, K. Luskey (1987)
Partial deletion of membrane-bound domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase eliminates sterol-enhanced degradation and prevents formation of crystalloid endoplasmic reticulumThe Journal of Cell Biology, 104
-
A. Habenicht, J. Glomset, R. Ross (1980)
Relation of cholesterol and mevalonic acid to the cell cycle in smooth muscle and swiss 3T3 cells stimulated to divide by platelet-derived growth factor.The Journal of biological chemistry, 255 11
-
E. Repko, W. Maltese (1989)
Post-translational isoprenylation of cellular proteins is altered in response to mevalonate availability.The Journal of biological chemistry, 264 17
-
Catherine Clarke, Richard Tanaka, Karen Svenson, Maria Wamsley, A. Fogelman, Peter Edwards (1987)
Molecular Cloning and Sequence of a Cholesterol-Repressible Enzyme Related to Prenyltransferase in the Isoprene Biosynthetic PathwayMolecular and Cellular Biology, 8
-
T. Osborne, J. Goldstein, Michael Brown (1985)
5′ end of hmg CoA reductase gene contains sequences responsible for cholesterol-mediated inhibition of transcriptionCell, 42
-
C. Farnsworth, S. Wolda, M. Gelb, J. Glomset (1989)
Human lamin B contains a farnesylated cysteine residue.The Journal of biological chemistry, 264 34
-
N. Segev, J. Mulholland, D. Botstein (1988)
The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machineryCell, 52
-
T. Rajavashisth, A. Taylor, A. Andalibi, K. Svenson, A. Lusis (1989)
Identification of a zinc finger protein that binds to the sterol regulatory element.Science, 245 4918
-
T. Osborne, G. Gil, J. Goldstein, M. Brown (1988)
Operator constitutive mutation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter abolishes protein binding to sterol regulatory element.The Journal of biological chemistry, 263 7
-
Jeffrey Smith, Timothy Osbornes, Michael Brown, J. Goldstein, Gregorio Gilll (1988)
Multiple sterol regulatory elements in promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A synthase.The Journal of biological chemistry, 263 34
-
S. Clarke, J. Vogel, R. Deschenes, J. Stock (1988)
Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases.Proceedings of the National Academy of Sciences of the United States of America, 85 13
-
B. Goud, A. Salminen, N. Walworth, P. Novick (1988)
A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeastCell, 53
-
S. Panini, R. Schnitzer-Polokoff, T. Spencer, M. Sinensky (1989)
Sterol-independent regulation of 3-hydroxy-3-methylglutaryl-CoA reductase by mevalonate in Chinese hamster ovary cells. Magnitude and specificity.The Journal of biological chemistry, 264 19
-
J. Mcgrath, A. Varshavsky (1989)
The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoproteinNature, 340
-
Gary Reynolds, Joseph Goldstein, Michael Brown (1985)
Multiple mRNAs for 3-hydroxy-3-methylglutaryl coenzyme A reductase determined by multiple transcription initiation sites and intron splicing sites in the 5'-untranslated region.The Journal of biological chemistry, 260 18
-
S. Mosley, M. Brown, R. Anderson, J. Goldstein (1983)
Mutant clone of Chinese hamster ovary cells lacking 3-hydroxy-3 -methylglutaryl coenzyme A reductase.The Journal of biological chemistry, 258 22
-
JL Goldstein (1984)
10.1016/S0022-2275(20)34418-7J. Lipid Res., 25
-
Ravindra Pathak, K. Luskey, R. Anderson (1986)
Biogenesis of the crystalloid endoplasmic reticulum in UT-1 cells: evidence that newly formed endoplasmic reticulum emerges from the nuclear envelopeThe Journal of Cell Biology, 102
-
P. Pentchev, M. Comly, H. Kruth, T. Tokoro, J. Butler, J. Sokol, M. Filling-Katz, J. Quirk, D. Marshall, S. Patel, M. Vanier, R. Brady (1987)
Group C Niemann‐Pick disease: faulty regulation of low‐density lipoprotein uptake and cholesterol storage in cultured fibroblastsThe FASEB Journal, 1
-
M. Brown, J. Faust, J. Goldstein, I. Kaneko, A. Endo (1978)
Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase.The Journal of biological chemistry, 253 4
-
R. Learned, G. Fink (1989)
3-Hydroxy-3-methylglutaryl-coenzyme A reductase from Arabidopsis thaliana is structurally distinct from the yeast and animal enzymes.Proceedings of the National Academy of Sciences of the United States of America, 86 8
-
JR Smith (1988)
10.1016/S0021-9258(19)81383-2J. biol. Chem., 263
-
K. Luskey, J. Faust, D. Chin, M. Brown, J. Goldstein (1983)
Amplification of the gene for 3-hydroxy-3-methylglutaryl coenzyme A reductase, but not for the 53-kDa protein, in UT-1 cells.The Journal of biological chemistry, 258 13
-
J. Goldstein, S. Dana, J. Faust, Arthur Beaudet, Michael Brown (1975)
Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease.The Journal of biological chemistry, 250 21
-
M. Brown, J. Goldstein (1986)
A receptor-mediated pathway for cholesterol homeostasis.Science, 232 4746
-
Kenneth Luskeyg, Bryn Stevens (1985)
Human 3-hydroxy-3-methylglutaryl coenzyme A reductase. Conserved domains responsible for catalytic activity and sterol-regulated degradation.The Journal of biological chemistry, 260 18
-
F. Taylor, S. Saucier, E. Shown, E. Parish, A. Kandutsch (1984)
Correlation between oxysterol binding to a cytosolic binding protein and potency in the repression of hydroxymethylglutaryl coenzyme A reductase.The Journal of biological chemistry, 259 20
-
Ta-Yuan Chang, James, Limanek (1980)
Regulation of cytosolic acetoacetyl coenzyme A thiolase, 3-hydroxy-3-methylglutaryl coenzyme A synthase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and mevalonate kinase by low density lipoprotein and by 25-hydroxycholesterol in Chinese hamster ovary cells.The Journal of biological chemistry, 255 16
-
Michael Basson, M. Thorsness, J. Finer-Moore, Robert Stroud, Jasper Rine (1988)
Structural and functional conservation between yeast and human 3-hydroxy-3-methylglutaryl coenzyme A reductases, the rate-limiting enzyme of sterol biosynthesisMolecular and Cellular Biology, 8
-
D. Skalnik, R. Simoni (1985)
The nucleotide sequence of Syrian hamster HMG-CoA reductase cDNA.DNA, 4 6
-
P. Casey, P. Solski, C. Der, J. Buss (1989)
p21ras is modified by a farnesyl isoprenoid.Proceedings of the National Academy of Sciences of the United States of America, 86 21
-
F. Gertler, C. Chiu, L. Richter-Mann, D. Chin (1988)
Developmental and metabolic regulation of the Drosophila melanogaster 3-hydroxy-3-methylglutaryl coenzyme A reductaseMolecular and Cellular Biology, 8
-
(1988)
Biochim biophys -
M. Brown, G. Brunschede, J. Goldstein (1975)
Inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vitro. An adenine nucleotide-dependent reaction catalyzed by a factor in human fibroblasts.The Journal of biological chemistry, 250 7
-
T. Chang, C. Chang (1982)
Revertants of a Chinese hamster ovary cell mutant resistant to suppression by an analogue of cholesterol: isolation and partial biochemical characterization.Biochemistry, 21 21
-
FR Taylor (1984)
10.1016/S0021-9258(18)90757-XJ. biol. Chem., 259
-
JB Gibbs (1989)
10.1128/mr.53.2.171-185.1989Micro. Rev., 53
-
J. Hancock, A. Magee, J. Childs, C. Marshall (1989)
All ras proteins are polyisoprenylated but only some are palmitoylatedCell, 57
-
H. Woodward, J. Allen, W. Lennarz (1988)
3-Hydroxy-3-methylglutaryl-coenzyme A reductase of the sea urchin embryo. Deduced structure and regulatory properties.The Journal of biological chemistry, 263 34
-
P Dawson, S Hofmann, D. Westhuyzen, T Südhof, M. Brown, J. Goldstein (1988)
Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1.The Journal of biological chemistry, 263 7
-
Laura Liscum, J. Finer-Moore, Robert Stroud, K. Luskey, M. Brown, J. Goldstein (1985)
Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum.The Journal of biological chemistry, 260 1
-
P Dawson, D. Westhuyzen, J. Goldstein, M. Brown (1989)
Purification of oxysterol binding protein from hamster liver cytosol.The Journal of biological chemistry, 264 15
-
KL Luskey (1983)
10.1016/S0021-9258(20)82087-0J. biol. Chem., 258
-
K. Fairbanks, L. Witte, D. Goodman (1984)
Relationship between mevalonate and mitogenesis in human fibroblasts stimulated with platelet-derived growth factor.The Journal of biological chemistry, 259 3
-
J. Goldstein, M. Brown (1977)
The low-density lipoprotein pathway and its relation to atherosclerosis.Annual review of biochemistry, 46
-
A. Rajković, J. Simonsen, R. Davis, F. Rottman (1989)
Molecular cloning and sequence analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase from the human parasite Schistosoma mansoni.Proceedings of the National Academy of Sciences of the United States of America, 86 21
-
W. Dynan (1986)
Promoters for housekeeping genesTrends in Genetics, 2
-
S. Wolda, J. Glomset (1988)
Evidence for modification of lamin B by a product of mevalonic acid.The Journal of biological chemistry, 263 13
-
D. Hardie, D. Carling, A. Sim (1989)
The AMP-activated protein kinase: a multisubstrate regulator of lipid metabolismTrends in Biochemical Sciences, 14
-
R. Anderson, L. Orci, Michael Brown, L. Garcia-Segura, J. Goldstein (1983)
Ultrastructural analysis of crystalloid endoplasmic reticulum in UT-1 cells and its disappearance in response to cholesterol.Journal of cell science, 63
-
G. Reynolds, S. Basu, T. Osborne, D. Chin, G. Gil, Michael Brown, J. Goldstein, K. Luskey (1984)
HMG CoA reductase: A negatively regulated gene with unusual promoter and 5′ untranslated regionsCell, 38
-
(1989)
Russell for helpful discussions and careful reading of the manuscript. NATURE -
PA Dawson (1989)
10.1016/S0021-9258(19)84776-2J. biol. Chem., 264
-
Y Gruenbaum (1988)
10.1083/jcb.106.3.585J. Cell Biol., 106
-
FB Gertler (1988)
10.1128/MCB.8.7.2713Molec. cell. Biol., 8
-
L. Liscum, Regina Ruggiero, J. Faust (1989)
The intracellular transport of low density lipoprotein-derived cholesterol is defective in Niemann-Pick type C fibroblastsThe Journal of Cell Biology, 108
-
HD Woodward (1988)
10.1016/S0021-9258(19)81374-1J. biol. Chem., 263
-
G. Gil, T. Osborne, J. Goldstein, M. Brown (1988)
Purification of a protein doublet that binds to six TGG-containing sequences in the promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase.The Journal of biological chemistry, 263 35
-
W. Maltese, J. Aprille, R. Green (1987)
Activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase does not respond to ubiquinone uptake in cultured cells.The Biochemical journal, 246 2
-
A. Kandutsch, H. Chen, H. Heiniger (1978)
Biological activity of some oxygenated sterols.Science, 201 4355
-
G. Gil, J. Faust, D. Chin, J. Goldstein, Michael Brown (1985)
Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzymeCell, 41
-
M. Brown, J. Goldstein (1980)
Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.Journal of lipid research, 21 5
-
J. Goldstein, M. Brown (1984)
Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol.Journal of lipid research, 25 13
-
R. Schmidt, C. Schneider, John GlomsetS (1984)
Evidence for post-translational incorporation of a product of mevalonic acid into Swiss 3T3 cell proteins.The Journal of biological chemistry, 259 16
-
RGW Anderson (1983)
10.1242/jcs.63.1.1J. Cell Sci., 63
- Publisher
- Springer Journals
- Copyright
- Copyright © 1990 by Nature Publishing Group
- Subject
- Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
- ISSN
- 0028-0836
- eISSN
- 1476-4687
- DOI
- 10.1038/343425a0
- Publisher site
- See Article on Publisher Site
Abstract
The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease.
Journal
Nature – Springer Journals
Published: Feb 1, 1990