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ACTH and Cortisol Secretory Patterns in Man

ACTH and Cortisol Secretory Patterns in Man Plasma concentrations of ACTH (by radioimmunoassay) and cortisol (by competitive protein binding) were measured in a normal man at 5-min intervals from 0100 to 0900 hr. During this time there were 18 episodes of ACTH secretion and 13 episodes of cortisol secretion. On occasion, 2 or more episodes of ACTH secretion in close temporal relationship were reflected in a single sustained elevation of cortisol concentration. Estimates were obtained of the amounts of ACTH produced per episode which ranged from 0.5 μg to 4.5 μg at an average rate over the whole study of 0.29 μg per min. The plasma concentrations achieved in most instances were more than sufficient to produce maximal adrenal secretion of cortisol. Cortisol secretion began about 10 min after initiation of ACTH secretion. Cortisol secretion ranged from 0.1 mg to 2.9 mg per episode at an average rate over the whole study of 105 (μg/min. It is concluded that any sampling period longer than 5 min gives an erroneous depiction of events and this was exemplified by a simulated 20-min sampling of the 5-min mode data. This content is only available as a PDF. Author notes This work has been supported by grants from the National Institutes of Health CA-07304, General Clinical Research Centers RR-53, National Institutes of Mental Health MH-13269. Copyright © 1973 by The Endocrine Society http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Endocrinology and Metabolism Oxford University Press

ACTH and Cortisol Secretory Patterns in Man

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Publisher
Oxford University Press
Copyright
Copyright © 1973 by The Endocrine Society
ISSN
0021-972X
eISSN
1945-7197
DOI
10.1210/jcem-36-6-1058
Publisher site
See Article on Publisher Site

Abstract

Plasma concentrations of ACTH (by radioimmunoassay) and cortisol (by competitive protein binding) were measured in a normal man at 5-min intervals from 0100 to 0900 hr. During this time there were 18 episodes of ACTH secretion and 13 episodes of cortisol secretion. On occasion, 2 or more episodes of ACTH secretion in close temporal relationship were reflected in a single sustained elevation of cortisol concentration. Estimates were obtained of the amounts of ACTH produced per episode which ranged from 0.5 μg to 4.5 μg at an average rate over the whole study of 0.29 μg per min. The plasma concentrations achieved in most instances were more than sufficient to produce maximal adrenal secretion of cortisol. Cortisol secretion began about 10 min after initiation of ACTH secretion. Cortisol secretion ranged from 0.1 mg to 2.9 mg per episode at an average rate over the whole study of 105 (μg/min. It is concluded that any sampling period longer than 5 min gives an erroneous depiction of events and this was exemplified by a simulated 20-min sampling of the 5-min mode data. This content is only available as a PDF. Author notes This work has been supported by grants from the National Institutes of Health CA-07304, General Clinical Research Centers RR-53, National Institutes of Mental Health MH-13269. Copyright © 1973 by The Endocrine Society

Journal

Journal of Clinical Endocrinology and Metabolism – Oxford University Press

Published: Jun 1, 1973

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