Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/oncogenes-in-melanoma-LYHQ7NILfY
References (37)
-
D. Becker, C. Meier, M. Herlyn (1989)
Proliferation of human malignant melanomas is inhibited by antisense oligodeoxynucleotides targeted against basic fibroblast growth factor.The EMBO Journal, 8
-
M. Stas, H. Degreef, A. Demunter, C. Wolf‐peeters, J. Oord (2001)
Analysis of N- and K-ras mutations in the distinctive tumor progression phases of melanoma.The Journal of investigative dermatology, 117 6
-
F. Meier, M. Nesbit, M. Hsu, Bernard Martin, P. Belle, D. Elder, G. Schaumburg‐Lever, C. Garbe, Tania Walz, P. Donatien, T. Crombleholme, M. Herlyn (2000)
Human melanoma progression in skin reconstructs : biological significance of bFGF.The American journal of pathology, 156 1
-
G. Kraehn, J. Utikal, M. Udart, K. Greulich, G. Bezold, P. Kaskel, U. Leiter, R. Peter (2001)
Extra c-myc oncogene copies in high risk cutaneous malignant melanoma and melanoma metastasesBritish Journal of Cancer, 84
-
J. Momand, David Jung, S. Wilczynski, J. Niland (1998)
The MDM2 gene amplification database.Nucleic acids research, 26 15
-
S. Cory, Jerry Adams (2002)
The Bcl2 family: regulators of the cellular life-or-death switchNature Reviews Cancer, 2
-
H. Rubié, O. Hartmann, J. Michon, D. Frappaz, C. Coze, P. Chastagner, M. Baranzelli, D. Plantaz, H. Avet‐Loiseau, J. Bénard, O. Delattre, M. Favrot, M. Peyroulet, A. Thyss, Y. Pérel, C. Bergeron, B. Courbon-Collet, J. Vannier, J. Lemerle, D. Sommelet (1997)
N-Myc gene amplification is a major prognostic factor in localized neuroblastoma: results of the French NBL 90 study. Neuroblastoma Study Group of the Société Francaise d'Oncologie Pédiatrique.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 15 3
-
T. Wölfel, M. Hauer, J. Schneider, M. Serrano, C. Wölfel, E. Klehmann-Hieb, E. Plaen, T. Hankeln, K. Büschenfelde, D. Beach (1995)
A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanomaScience, 269
-
D. Grossman, P. Kim, J. Schechner, D. Altieri (2001)
Inhibition of melanoma tumor growth in vivo by survivin targeting.Proceedings of the National Academy of Sciences of the United States of America, 98 2
-
R. Böni, O. Bantschapp, B. Müller, G. Burg (1998)
c-myc Is Not Useful as Prognostic Immunohistochemical Marker in Cutaneous MelanomaDermatology, 196
-
E. Clark, T. Golub, E. Lander, R. Hynes (2000)
Genomic analysis of metastasis reveals an essential role for RhoCNature, 406
-
D. Polsky, K. Melzer, Carole Hazan, K. Panageas, K. Busam, M. Drobnjak, H. Kamino, J. Spira, A. Kopf, A. Houghton, C. Cordon-Cardo, I. Osman (2002)
HDM2 protein overexpression and prognosis in primary malignant melanoma.Journal of the National Cancer Institute, 94 23
-
A. Weeraratna, Yuan Jiang, G. Hostetter, K. Rosenblatt, P. Duray, M. Bittner, J. Trent (2002)
Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma.Cancer cell, 1 3
-
J. Chana, R. Grover, G. Wilson, D. Hudson, M. Forders, R. Sanders, A. Grobbelaar (2001)
The Prognostic Importance of c-myc Oncogene Expression in Head and Neck MelanomaAnnals of Plastic Surgery, 47
-
P. Pollock, Ursula Harper, Katherine Hansen, Laura Yudt, M. Stark, C. Robbins, T. Moses, G. Hostetter, U. Wagner, J. Kakareka, Ghadi Salem, T. Pohida, P. Heenan, P. Duray, O. Kallioniemi, N. Hayward, J. Trent, P. Meltzer (2003)
High frequency of BRAF mutations in neviNature Genetics, 33
-
L. Zuo, J. Weger, Qin Yang, A. Goldstein, M. Tucker, G. Walker, N. Hayward, N. Dracopoli (1996)
Germline mutations in the p16INK4a binding domain of CDK4 in familial melanomaNature Genetics, 12
-
H. Davies, G. Bignell, Charles Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, Mathew Garnett, W. Bottomley, Neil Davis, E. Dicks, Rebecca Ewing, Yvonne Floyd, K. Gray, S. Hall, R. Hawes, Jaime Hughes, Vivian Kosmidou, A. Menzies, Catherine Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, Rebecca Wilson, H. Jayatilake, B. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. Riggins, D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, Judy Ho, Suet Leung, S. Yuen, Barbara Weber, H. Seigler, T. Darrow, H. Paterson, R. Marais, Christopher Marshall, R. Wooster, Michael Stratton, P. Futreal (2002)
Mutations of the BRAF gene in human cancerNature, 417
-
C. Tabin, S. Bradley, Cori Bargmann, R. Weinberg, A. Papageorge, E. Scolnick, R. Dhar, D. Lowy, E. Chang (1982)
Mechanism of activation of a human oncogeneNature, 300
-
R. Halaban (1991)
Growth factors and tyrosine protein kinases in normal and malignant melanocytesCancer and Metastasis Reviews, 10
-
P. Innominato, L. Libbrecht, J. Oord (2001)
Expression of neurotrophins and their receptors in pigment cell lesions of the skinThe Journal of Pathology, 194
-
S. Ries, C. Biederer, D. Woods, O. Shifman, S. Shirasawa, T. Sasazuki, M. McMahon, M. Oren, F. McCormick (2000)
Opposing Effects of Ras on p53 Transcriptional Activation of mdm2 and Induction of p19ARFCell, 103
-
J. Owen, R. Strieter, M. Burdick, H. Haghnegahdar, L. Nanney, R. Shattuck-Brandt, A. Richmond (1997)
Enhanced tumor‐forming capacity for immortalized melanocytes expressing melanoma growth stimulatory activity/growth‐regulated cytokine β and γ proteinsInternational Journal of Cancer, 73
-
L. Chin, J. Pomerantz, D. Polsky, D. Polsky, M. Jacobson, Carlos Cohen, C. Cordon-Cardo, J. Horner, R. DePinho (1997)
Cooperative effects of INK4a and ras in melanoma susceptibility in vivo.Genes & development, 11 21
-
D. Tuveson, Nicholas Willis, T. Jacks, J. Griffin, S. Singer, C. Fletcher, J. Fletcher, G. Demetri (2001)
STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implicationsOncogene, 20
-
M. Bittner, P. Meltzer, Yidong Chen, Yong-hui Jiang, E. Seftor, M. Hendrix, M. Radmacher, R. Simon, Z. Yakhini, A. Ben-Dor, N. Sampas, E. Dougherty, E. Wang, F. Marincola, C. Gooden, J. Lueders, A. Glatfelter, Pamela Pollock, J. Carpten, E. Gillanders, D. Leja, K. Dietrich, C. Beaudry, M. Berens, D. Alberts, V. Sondak (2000)
Molecular classification of cutaneous malignant melanoma by gene expression profilingNature, 406
-
H. Varmus (1985)
Alfred P. Sloan prize. Viruses, genes, and cancer. I. The discovery of cellular oncogenes and their role in neoplasiaCancer, 55
-
RA Willis (1952)
The Spread of Tumors in the Human Body -
B. Bastian, P. Leboit, D. Pinkel (2000)
Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features.The American journal of pathology, 157 3
-
J. Pasternak (2000)
An Introduction to Human Molecular Genetics: Mechanisms of Inherited Diseases -
K. Satyamoorthy, Meenhard Herlyn (2002)
Cellular and Molecular Biology of Human MelanomaCancer Biology & Therapy, 1
-
Yiping Wang, D. Becker (1997)
Antisense targeting of basic fibroblast growth factor and dibroblast growth factor receptor-1 in human melanomas blocks intratumoral angiogenesis and tumor growthNature Medicine, 3
-
SV Hodgson, ER Maher (1997)
A Practical Guide to Human Cancer Genetics, 2nd edn -
Shinichiro Hayashi, Anna Kurdowska, Allen Cohen, Michael Stevens, N. Fujisawa, Edmund Miller (1997)
A synthetic peptide inhibitor for alpha-chemokines inhibits the growth of melanoma cell lines.The Journal of clinical investigation, 99 11
-
Sushil Rane, S. Cosenza, R. Mettus, E. Reddy (2002)
Germ Line Transmission of the Cdk4R24C Mutation Facilitates Tumorigenesis and Escape from Cellular SenescenceMolecular and Cellular Biology, 22
-
K. Kinzler, B. Vogelstein (1996)
Lessons from Hereditary Colorectal CancerCell, 87
-
R. Sotillo, Juan García, S. Ortega, Javier Martín, P. Dubus, M. Barbacid, Marcos Malumbres (2001)
Invasive melanoma in Cdk4-targeted miceProceedings of the National Academy of Sciences of the United States of America, 98
-
U. Leiter, R. Schmid, P. Kaskel, R. Peter, G. Krähn (2000)
Antiapoptotic bcl-2 and bcl-xL in advanced malignant melanomaArchives of Dermatological Research, 292
- Publisher
- Springer Journals
- Copyright
- Copyright © 2003 by Nature Publishing Group
- Subject
- Medicine & Public Health; Medicine/Public Health, general; Internal Medicine; Cell Biology; Human Genetics; Oncology; Apoptosis
- ISSN
- 0950-9232
- eISSN
- 1476-5594
- DOI
- 10.1038/sj.onc.1206449
- Publisher site
- See Article on Publisher Site
Abstract
Transformation of normal melanocytes into melanoma cells is accomplished by the activation of growth stimulatory pathways, typically leading to cellular proliferation, and the inactivation of apoptotic and tumor suppressor pathways. Small molecule inhibitors of proteins in the growth stimulatory pathways are under active investigation, and their application to melanoma patients would represent a new treatement strategy to inhibit cell proliferation or induce cell death. We provide a general overview of the mechanisms of oncogene activation and the functions of oncogenes. Lastly, we review oncogenic events in melanoma.
Journal
Oncogene – Springer Journals
Published: May 19, 2003