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Resection of Hepatic Metastases From Colorectal Cancer

Resection of Hepatic Metastases From Colorectal Cancer Abstract • We studied 141 patients who had resection of hepatic metastases from colorectal cancer, considering all such lesions removed between 1948 and 1982. The study involved extended observations of patients described previously. Also included were 21 patients who had wedge resections of small metastases done since 1976, who, therefore, did not qualify for analysis of major hepatic resections reported recently (1980 and 1983). The overall five-year survival rate was 25%, significantly higher than that of a group of historical controls who had resectable metastases that were not removed. The size and nature of our extended sample allowed identification of some determinants of favorable prognosis: Dukes' stage of the primary lesion, absence of extrahepatic metastases, and being female. Contrary to our earlier observations, this study justified removal of some multiple hepatic metastases. (Arch Surg 1984;119:647-651) References 1. Foster JH: Treatment of metastatic cancer to liver , in Devita VT Jr, Hellman S, Rosenberg SA (eds): Cancer: Principles and Practice of Oncology . Philadelphia, JB Lippincott Co, 1982, pp 1553-1563. 2. Fortner JG, Maclean BJ, Kim DK, et al: The 70s evolution in liver surgery for cancer . Cancer 1981;47:2162-2166.Crossref 3. Starzl TE, Koep LJ, Weil R III, et al: Right trisegmentectomy for hepatic neoplasms . Surg Gynecol Obstet 1980;150:208-214. 4. Logan SE, Meier SJ, Ramming KP, et al: Hepatic resection of metastatic colorectal carcinoma: A ten-year experience . Arch Surg 1982; 117:25-28.Crossref 5. Adson MA: Cannon lecture: Hepatic metastases in perspective . AJR 1983;140:695-700.Crossref 6. Bengmark S, Hafström L: The natural history of primary and secondary malignant tumors of the liver: I. The prognosis for patients with hepatic metastases from colonic and rectal carcinoma by laparotomy . Cancer 1969;23:198-202.Crossref 7. Wood CB, Gillis CR, Blumgart LH: A retrospective study of the natural history of patients with liver metastases from colorectal cancer . Clin Oncol 1976;2:285-288. 8. Jaffe BM, Donegan WL, Watson F, et al: Factors influencing survival in patients with untreated hepatic metastases . Surg Gynecol Obstet 1968; 127:1-11. 9. Wanebo HJ, Semoglou C, Attiyeh F, et al: Surgical management of patients with primary operable colorectal cancer and synchronous liver metastases . Am J Surg 1978;135:81-84.Crossref 10. Wilson SM, Adson MA: Surgical treatment of hepatic metastases from colorectal cancers . Arch Surg 1976;111:330-334.Crossref 11. Adson MA, van Heerden JA: Major hepatic resections for metastatic colorectal cancer . Ann Surg 1980;191:576-583.Crossref 12. Kaplan EL, Meier P: Nonparametric estimation from incomplete observations . J Am Stat Assoc 1958;53:457-481.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Resection of Hepatic Metastases From Colorectal Cancer

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References (13)

Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1984.01390180015003
Publisher site
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Abstract

Abstract • We studied 141 patients who had resection of hepatic metastases from colorectal cancer, considering all such lesions removed between 1948 and 1982. The study involved extended observations of patients described previously. Also included were 21 patients who had wedge resections of small metastases done since 1976, who, therefore, did not qualify for analysis of major hepatic resections reported recently (1980 and 1983). The overall five-year survival rate was 25%, significantly higher than that of a group of historical controls who had resectable metastases that were not removed. The size and nature of our extended sample allowed identification of some determinants of favorable prognosis: Dukes' stage of the primary lesion, absence of extrahepatic metastases, and being female. Contrary to our earlier observations, this study justified removal of some multiple hepatic metastases. (Arch Surg 1984;119:647-651) References 1. Foster JH: Treatment of metastatic cancer to liver , in Devita VT Jr, Hellman S, Rosenberg SA (eds): Cancer: Principles and Practice of Oncology . Philadelphia, JB Lippincott Co, 1982, pp 1553-1563. 2. Fortner JG, Maclean BJ, Kim DK, et al: The 70s evolution in liver surgery for cancer . Cancer 1981;47:2162-2166.Crossref 3. Starzl TE, Koep LJ, Weil R III, et al: Right trisegmentectomy for hepatic neoplasms . Surg Gynecol Obstet 1980;150:208-214. 4. Logan SE, Meier SJ, Ramming KP, et al: Hepatic resection of metastatic colorectal carcinoma: A ten-year experience . Arch Surg 1982; 117:25-28.Crossref 5. Adson MA: Cannon lecture: Hepatic metastases in perspective . AJR 1983;140:695-700.Crossref 6. Bengmark S, Hafström L: The natural history of primary and secondary malignant tumors of the liver: I. The prognosis for patients with hepatic metastases from colonic and rectal carcinoma by laparotomy . Cancer 1969;23:198-202.Crossref 7. Wood CB, Gillis CR, Blumgart LH: A retrospective study of the natural history of patients with liver metastases from colorectal cancer . Clin Oncol 1976;2:285-288. 8. Jaffe BM, Donegan WL, Watson F, et al: Factors influencing survival in patients with untreated hepatic metastases . Surg Gynecol Obstet 1968; 127:1-11. 9. Wanebo HJ, Semoglou C, Attiyeh F, et al: Surgical management of patients with primary operable colorectal cancer and synchronous liver metastases . Am J Surg 1978;135:81-84.Crossref 10. Wilson SM, Adson MA: Surgical treatment of hepatic metastases from colorectal cancers . Arch Surg 1976;111:330-334.Crossref 11. Adson MA, van Heerden JA: Major hepatic resections for metastatic colorectal cancer . Ann Surg 1980;191:576-583.Crossref 12. Kaplan EL, Meier P: Nonparametric estimation from incomplete observations . J Am Stat Assoc 1958;53:457-481.Crossref

Journal

Archives of Surgery – American Medical Association

Published: Jun 1, 1984

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