Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/wiley/characterization-of-human-circulating-tig2-as-a-ligand-for-the-orphan-Lipgr8oU3f
References (18)
-
D. Hock, Markus Mägerlein, Gabi Heine, P. Ochlich, W. Forssmann (1997)
Isolation and characterization of the bioactive circulating human parathyroid hormone, hPTH‐1–37FEBS Letters, 400
-
A. Methner, G. Hermey, B. Schinke, I. Hermans-Borgmeyer (1997)
A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development.Biochemical and biophysical research communications, 233 2
-
H. Mägert, M. Reinecke, I. David, H. Raab, K. Adermann, H. Zucht, O. Hill, R. Hess, W. Forssmann (1998)
Uroguanylin: Gene structure, expression, processing as a peptide hormone, and co-storage with somatostatin in gastrointestinal D-cellsRegulatory Peptides, 73
-
A. Adams, Y. Abu-Amer, J. Chappel, Sharon Stueckle, F. Ross, S. Teitelbaum, L. Suva (1999)
1,25 dihydroxyvitamin D3 and dexamethasone induce the cyclooxygenase 1 gene in osteoclast‐supporting stromal cellsJournal of Cellular Biochemistry, 74
-
R. Richter, P. Schulz-Knappe, M. Schrader, L. Ständker, M. Jürgens, H. Tammen, W. Forssmann (1999)
Composition of the peptide fraction in human blood plasma: database of circulating human peptides.Journal of chromatography. B, Biomedical sciences and applications, 726 1-2
-
P. Schulz-Knappe, Michael Schrader, L. Ständker, Rudolf Richter, Rüdiger Hess, M. Jürgens, W. Forssmann (1997)
Peptide bank generated by large-scale preparation of circulating human peptides.Journal of chromatography. A, 776 1
-
Hans-Peter Lammerich, A. Busmann, C. Kutzleb, M. Wendland, P. Seiler, C. Berger, P. Eickelmann, M. Meyer, W. Forssmann, E. Maronde (2003)
Identification and functional characterization of hemorphins VV‐H‐7 and LVV‐H‐7 as low‐affinity agonists for the orphan bombesin receptor subtype 3British Journal of Pharmacology, 138
-
M. Detheux, L. Ständker, J. Vakili, J. Münch, U. Forssmann, K. Adermann, S. Pöhlmann, G. Vassart, F. Kirchhoff, M. Parmentier, W. Forssmann (2000)
Natural Proteolytic Processing of Hemofiltrate Cc Chemokine 1 Generates a Potent Cc Chemokine Receptor (Ccr)1 and Ccr5 Agonist with Anti-HIV PropertiesThe Journal of Experimental Medicine, 192
-
M. Duvic, S. Nagpal, A. Asano, R. Chandraratna (1997)
Molecular mechanisms of tazarotene action in psoriasis.Journal of the American Academy of Dermatology, 37 2 Pt 3
-
V. Wittamer, J. Franssen, M. Vulcano, J. Mirjolet, E. Poul, I. Migeotte, S. Brézillon, R. Tyldesley, C. Blanpain, M. Detheux, A. Mantovani, S. Sozzani, G. Vassart, M. Parmentier, D. Communi (2003)
Specific Recruitment of Antigen-presenting Cells by Chemerin, a Novel Processed Ligand from Human Inflammatory FluidsThe Journal of Experimental Medicine, 198
-
M. Samson, A. Edinger, P. Stordeur, J. Rucker, V. Verhasselt, M. Sharron, C. Govaerts, C. Mollereau, G. Vassart, R. Doms, M. Parmentier (1998)
ChemR23, a putative chemoattractant receptor, is expressed in monocyte‐derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV‐1 strainsEuropean Journal of Immunology, 28
-
S. Nagpal, Sheetal Patel, H. Jacobe, D. Disepio, C. Ghosn, M. Malhotra, M. Teng, M. Duvic, R. Chandraratna (1997)
Tazarotene-induced gene 2 (TIG2), a novel retinoid-responsive gene in skin.The Journal of investigative dermatology, 109 1
-
Pierre Chambon (1994)
The retinoid signaling pathway: molecular and genetic analyses.Seminars in cell biology, 5 2
-
M. Sporn, A. Roberts, D. Goodman (1994)
The Retinoids : biology, chemistry, and medicine -
M. Boehm, R. Heyman, Sheetal Patel, R. Stein, S. Nagpal (1995)
Section Review: Retinoids: Biological Function and Use in the Treatment of Dermatological Diseases: Pulmonary-Allergy, Dermatological, Gastrointestinal & ArthritisExpert Opinion on Investigational Drugs, 4
-
W. Forssmann, P. Schulz-Knappe, M. Meyer, K. Adermann, K. Forssmann, D. Hock, A. Aoki (1993)
Characterization of natural posttranslationally processed peptides from human blood: A new tool in the systematic investigation of native peptides -
P. Schulz-Knappe, H. Mägert, Beatrice Dewald, M. Meyer, Y. Cetin, M. Kubbies, J. Tomeczkowski, Karin Kirchhoff, Manfred Raida, K. Adermann, A. Kist, Manfred Reinecke, R. Sillard, A. Pardigol, M. Uguccioni, Marco Baggiolini, W. Forssmann (1996)
HCC-1, a novel chemokine from human plasmaThe Journal of Experimental Medicine, 183
-
Sunil Nagpal, Sylvie Friant, H. Nakshatri, P. Chambon (1993)
RARs and RXRs: evidence for two autonomous transactivation functions (AF‐1 and AF‐2) and heterodimerization in vivo.The EMBO Journal, 12
- Publisher
- Wiley
- Copyright
- © 2015 Federation of European Biochemical Societies
- eISSN
- 1873-3468
- DOI
- 10.1016/S0014-5793(03)01312-7
- Publisher site
- See Article on Publisher Site
Abstract
The orphan receptor ChemR23 is a G‐protein coupled receptor (GPCR) with homology to neuropeptide and chemoattractant receptors. Tazarotene, a synthetic retinoid activating retinoic acid receptor (RAR), up‐regulates tazarotene‐induced gene‐2 (TIG2). The function and molecular target of this protein are now described. By means of reverse pharmacology screening using a peptide library generated from human hemofiltrate, we have isolated and identified TIG2 as the natural ligand of ChemR23 and report the specific molecular form of the bioactive, circulating TIG2, representing the amino‐acid residues 21 to 154 of the 163 amino acid‐containing prepropeptide. Based on the expression pattern of ChemR23 and TIG2, the physiological role in bone development, immune and inflammatory responses and the maintenance of skin is now being investigated.
Journal
FEBS Letters – Wiley
Published: Dec 18, 2003
Keywords: ; ; ; ; ; ; ; ; ; ;