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Development and Validation of a Culturally Adapted, Event-related Potential Paradigm for Assessing Alcohol Cue Reactivity and Error Processing in Alcohol Dependence

Development and Validation of a Culturally Adapted, Event-related Potential Paradigm for... Background:Research on event-related potentials (ERP) in addiction highlights the importance of cognitive ERP markers, such as P300 and error-related negativity (ERN), in distinguishing between alcohol-dependent patients and healthy controls. We aimed to develop and validate ERP paradigms utilizing culturally validated stimuli to evoke P300 and ERN for the Indian population.Methods:In a cross-sectional study, 16 alcohol-dependent patients and age-matched healthy controls were recruited. For P300, we designed a visual oddball (Go/No-Go) task using culturally appropriate alcohol and non-alcohol-related images. To study ERN, we used the Assessing Neurocognition via Gamified Experimental Logic (ANGEL) task, developed in India, integrating its “game” levels to capture error monitoring with fewer trials. A 32-channel EEG-ERP system was used for data acquisition.Results:Participants showed high engagement in the visual Go/No-Go task, with 94.4% accuracy. The P300 difference wave showed significantly higher amplitudes (p = .01, Cohen’s d = 0.97) and latencies (p < .001, Cohen’s d = 1.62) in patients compared to controls at the Pz electrode. No significant group differences were found in accuracy or reaction times for frequent and rare stimuli. In the ANGEL task, patients had a significantly lower ERN difference wave amplitude at the Pz electrode than controls (p < .001, Cohen’s d = 1.47), with no latency differences. Task accuracy was lower, and reaction time was longer in patients.Conclusions:The visual Go/No-Go task and the ANGEL task are promising tools for understanding the neurocognitive mechanisms underlying alcohol dependence in the Indian context. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Indian Journal of Psychological Medicine SAGE

Development and Validation of a Culturally Adapted, Event-related Potential Paradigm for Assessing Alcohol Cue Reactivity and Error Processing in Alcohol Dependence

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References (82)

Publisher
SAGE
Copyright
© 2024 The Author(s)
ISSN
0253-7176
eISSN
0975-1564
DOI
10.1177/02537176241266879
Publisher site
See Article on Publisher Site

Abstract

Background:Research on event-related potentials (ERP) in addiction highlights the importance of cognitive ERP markers, such as P300 and error-related negativity (ERN), in distinguishing between alcohol-dependent patients and healthy controls. We aimed to develop and validate ERP paradigms utilizing culturally validated stimuli to evoke P300 and ERN for the Indian population.Methods:In a cross-sectional study, 16 alcohol-dependent patients and age-matched healthy controls were recruited. For P300, we designed a visual oddball (Go/No-Go) task using culturally appropriate alcohol and non-alcohol-related images. To study ERN, we used the Assessing Neurocognition via Gamified Experimental Logic (ANGEL) task, developed in India, integrating its “game” levels to capture error monitoring with fewer trials. A 32-channel EEG-ERP system was used for data acquisition.Results:Participants showed high engagement in the visual Go/No-Go task, with 94.4% accuracy. The P300 difference wave showed significantly higher amplitudes (p = .01, Cohen’s d = 0.97) and latencies (p < .001, Cohen’s d = 1.62) in patients compared to controls at the Pz electrode. No significant group differences were found in accuracy or reaction times for frequent and rare stimuli. In the ANGEL task, patients had a significantly lower ERN difference wave amplitude at the Pz electrode than controls (p < .001, Cohen’s d = 1.47), with no latency differences. Task accuracy was lower, and reaction time was longer in patients.Conclusions:The visual Go/No-Go task and the ANGEL task are promising tools for understanding the neurocognitive mechanisms underlying alcohol dependence in the Indian context.

Journal

Indian Journal of Psychological Medicine – SAGE

Published: Jan 1, 2024

Keywords: Event-related potentials (ERP); P300; error-related negativity (ERN); alcohol dependence; cue reactivity; error processing; Go/No-Go task; Assessing Neurocognition via Gamified Experimental Logic (ANGEL) task

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