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References (16)
-
D. Willenborg, S. Fordham, C. Bernard, W. Cowden, I. Ramshaw (1996)
IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis.Journal of immunology, 157 8
-
B. Gran, Guang-Xian Zhang, Shuo Yu, Jifen Li, Xiaohan Chen, E. Ventura, M. Kamoun, A. Rostami (2002)
IL-12p35-Deficient Mice Are Susceptible to Experimental Autoimmune Encephalomyelitis: Evidence for Redundancy in the IL-12 System in the Induction of Central Nervous System Autoimmune Demyelination1The Journal of Immunology, 169
-
Y. Ke, Ke-Jo Liu, Guo-qiang Huang, Yan Cui, H. Kaplan, H. Shao, Deming Sun (2009)
Anti-Inflammatory Role of IL-17 in Experimental Autoimmune Uveitis1The Journal of Immunology, 182
-
Stefan Haak, Andrew Croxford, Katharina Kreymborg, F. Heppner, S. Pouly, B. Becher, A. Waisman (2008)
IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice.The Journal of clinical investigation, 119 1
-
R. Ransohoff, P. Kivisäkk, G. Kidd (2003)
Three or more routes for leukocyte migration into the central nervous systemNature Reviews Immunology, 3
-
C. Langrish, Yi Chen, W. Blumenschein, J. Mattson, B. Basham, J. Sedgwick, T. Mcclanahan, R. Kastelein, D. Cua (2005)
IL-23 drives a pathogenic T cell population that induces autoimmune inflammationThe Journal of Experimental Medicine, 201
-
L. Steinman (2005)
Blocking adhesion molecules as therapy for multiple sclerosis: natalizumabNature Reviews Drug Discovery, 4
-
E. Bettelli, B. Sullivan, S. Szabo, R. Sobel, L. Glimcher, V. Kuchroo (2004)
Loss of T-bet, But Not STAT1, Prevents the Development of Experimental Autoimmune EncephalomyelitisThe Journal of Experimental Medicine, 200
-
B. Conti, I. Tabarean, Cristina Andrei, T. Bártfai (2004)
Cytokines and fever.Frontiers in bioscience : a journal and virtual library, 9
-
Eva Acosta-Rodriguez, L. Rivino, J. Geginat, D. Jarrossay, M. Gattorno, A. Lanzavecchia, F. Sallusto, G. Napolitani (2007)
Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cellsNature Immunology, 8
-
T. Yednock, C. Cannon, L. Fritz, F. Sánchez‐Madrid, L. Steinman, N. Karin (1992)
Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrinNature, 356
-
M. Sospedra, Roland Martin (2005)
Immunology of multiple sclerosis.Annual review of immunology, 23
-
H. Panitch, A. Haley, R. Hirsch, K. Johnson (1987)
EXACERBATIONS OF MULTIPLE SCLEROSIS IN PATIENTS TREATED WITH GAMMA INTERFERONThe Lancet, 329
-
B. Engelhardt, K. Wolburg-Buchholz, H. Wolburg (2001)
Involvement of the choroid plexus in central nervous system inflammationMicroscopy Research and Technique, 52
-
A. Reboldi, Caroline Coisne, Dirk Baumjohann, F. Benvenuto, D. Bottinelli, S. Lira, A. Uccelli, A. Lanzavecchia, B. Engelhardt, F. Sallusto (2009)
C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAENature Immunology, 10
-
J. Tzartos, M. Friese, M. Craner, J. Palace, J. Newcombe, M. Esiri, L. Fugger (2008)
Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis.The American journal of pathology, 172 1
- Publisher
- Springer Journals
- Copyright
- Copyright © 2009 by Nature Publishing Group
- Subject
- Biomedicine; Biomedicine, general; Immunology; Infectious Diseases
- ISSN
- 1529-2908
- eISSN
- 1529-2916
- DOI
- 10.1038/ni0509-453
- Publisher site
- See Article on Publisher Site
Abstract
Little is known about how pathogenic T cells gain access to the uninflamed brain in multiple sclerosis and experimental autoimmune encephalomyelitis. A new study reports that interleukin 17–producing T helper cells enter the uninflamed central nervous system through the choroid plexus by a CCR6-CCL20–dependent mechanism.
Journal
Nature Immunology – Springer Journals
Published: May 1, 2009