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References (32)
-
M. Maurer, B. Handjiski, R. Paus (1997)
Hair growth modulation by topical immunophilin ligands: induction of anagen, inhibition of massive catagen development, and relative protection from chemotherapy-induced alopecia.The American journal of pathology, 150 4
-
KS Stenn, R Paus (2001)
Controls of hair follicle cyclingPhysiol. Rev., 81
-
E. Johnson (1958)
Quantitative studies of hair growth in the albino rat. II. The effect of sex hormones.The Journal of endocrinology, 16 4
-
N. Suzuki, M. Hirata, Shigeru Kondo (2003)
Traveling stripes on the skin of a mutant mouseProceedings of the National Academy of Sciences of the United States of America, 100
-
V. Botchkarev, N. Botchkareva, W. Roth, Motonobu Nakamura, Ling Chen, W. Herzog, G. Lindner, J. McMahon, C. Peters, R. Lauster, A. McMahon, R. Paus (1999)
Noggin is a mesenchymally derived stimulator of hair-follicle inductionNature Cell Biology, 1
-
K. Stenn, A. Nixon, C. Jahoda, I. McKay, R. Paus (1999)
What controls hair follicle cycling?Experimental Dermatology, 8
-
M. Plikus, C. Chuong (2008)
Complex hair cycle domain patterns and regenerative hair waves in living rodents.The Journal of investigative dermatology, 128 5
-
W. Lowry, C. Blanpain, J. Nowak, Géraldine Guasch, L. Lewis, E. Fuchs (2005)
Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells.Genes & development, 19 13
-
A. Durward, K. Rudall (1949)
Studies on hair growth in the rat.Journal of anatomy, 83 4
-
Liang Ma, Jian Liu, Tobey Wu, M. Plikus, T. Jiang, Qun Bi, Yi-hsin Liu, Sven Müller-Röver, H. Peters, J. Sundberg, R. Maxson, R. Maas, C. Chuong (2003)
`Cyclic alopecia' in Msx2 mutants: defects in hair cycling and hair shaft differentiation, 130
-
E. Fuchs, T. Tumbar, Géraldine Guasch (2004)
Socializing with the Neighbors Stem Cells and Their NicheCell, 116
-
H. Chase (1954)
Growth of the hair.Physiological reviews, 34 1
-
M. Iguchi, S. Aiba, Y. Yoshino, H. Tagami (2001)
Human follicular papilla cells carry out nonadipose tissue production of leptin.The Journal of investigative dermatology, 117 6
-
P. Wu, L. Hou, M. Plikus, M. Hughes, J. Scehnet, S. Suksaweang, R. Widelitz, T. Jiang, C. Chuong (2004)
Evo-Devo of amniote integuments and appendages.The International journal of developmental biology, 48 2-3
-
J. Huelsken, Regina Vogel, B. Erdmann, G. Cotsarelis, W. Birchmeier (2001)
β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the SkinCell, 105
-
C. Celso, D. Prowse, F. Watt (2004)
Transient activation of β-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours, 131
-
R. Paus, K. Stenn, R. Link (1990)
Telogen skin contains an inhibitor of hair growthBritish Journal of Dermatology, 122
-
Jiwang Zhang, Xi He, Wei Tong, Teri Johnson, L. Wiedemann, Y. Mishina, Jian Feng, Linheng Li (2006)
Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and ExpansionSTEM CELLS, 24
-
F. Ebling, E. Johnson (1961)
Systemic influence on activity of hair follicles in skin homografts.Journal of embryology and experimental morphology, 9
-
Ying Zheng, Xiabing Du, Wei Wang, M. Boucher, S. Parimoo, K. Stenn (2005)
Organogenesis from dissociated cells: generation of mature cycling hair follicles from skin-derived cells.The Journal of investigative dermatology, 124 5
-
V. Botchkarev, N. Botchkareva, Motonobu Nakamura, O. Huber, K. Funa, R. Lauster, R. Paus, Barbara Gilchrest (2001)
Noggin is required for induction of the hair follicle growth phase in postnatal skinThe FASEB Journal, 15
-
E. Johnson (1958)
Quantitative studies of hair growth in the albino rat. III. The role of the adrenal glands.The Journal of endocrinology, 16 4
-
E. Sausville, A. Burger (2006)
Contributions of human tumor xenografts to anticancer drug development.Cancer research, 66 7
-
K. Militzer (2001)
Hair Growth Pattern in Nude MiceCells Tissues Organs, 168
-
K. Moore, I. Lemischka (2006)
Stem Cells and Their NichesScience, 311
-
Seshamma Reddy, T. Andl, A. Bagasra, M. Lu, D. Epstein, E. Morrisey, S. Millar (2001)
Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesisMechanisms of Development, 107
-
K. Kobielak, N. Stokes, June Cruz, Lisa Polak, E. Fuchs (2007)
Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signalingProceedings of the National Academy of Sciences, 104
-
A. Oro, K. Higgins (2003)
Hair cycle regulation of Hedgehog signal reception.Developmental biology, 255 2
-
R. Morris, Yaping Liu, L. Marles, Zaixin Yang, C. Trempus, Shulan Li, Jamie Lin, J. Sawicki, G. Cotsarelis (2004)
Capturing and profiling adult hair follicle stem cellsNature Biotechnology, 22
-
C. Blanpain, W. Lowry, A. Geoghegan, Lisa Polak, E. Fuchs (2004)
Self-Renewal, Multipotency, and the Existence of Two Cell Populations within an Epithelial Stem Cell NicheCell, 118
-
M. Plikus, Wen Wang, Jian Liu, Xia Wang, T. Jiang, C. Chuong (2004)
Morpho-regulation of ectodermal organs: integument pathology and phenotypic variations in K14-Noggin engineered mice through modulation of bone morphogenic protein pathway.The American journal of pathology, 164 3
-
Xi He, Jiwang Zhang, Wei Tong, O. Tawfik, J. Ross, D. Scoville, Qiang Tian, Xin Zeng, Xi He, L. Wiedemann, Y. Mishina, Linheng Li (2004)
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt–β-catenin signalingNature Genetics, 36
- Publisher
- Springer Journals
- Copyright
- Copyright © 2008 by Nature Publishing Group
- Subject
- Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
- ISSN
- 0028-0836
- eISSN
- 1476-4687
- DOI
- 10.1038/nature06457
- Publisher site
- See Article on Publisher Site
Abstract
Fur-coated mammals could teach us important lessons about the control of stem cell replication: their skins contain thousands of hair follicles that cycle between growth and rest phases, and somehow all the individual follicle stem cells are programmed to coordinate cell divisions. Bone morphogenetic proteins (BMPs) and their inhibitors have now been identified as central to the control of waves of hair follicle activity. In mice regenerating hair after a close shave, variations in BMP2 and BMP4 production both regulate hair growth in individual follicles and coordinate it with nearby follicles. This pair of signalling molecules also fits the description of chalone, a hypothetical molecule introduced 50 years ago to explain patterned hair growth. This work has implications for carcinogenesis and stem-cell engineering studies, many of which assume that mouse skin stays homogeneous during lengthy experiments.
Journal
Nature – Springer Journals
Published: Jan 17, 2008