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References (24)
-
J. Abraham, A. Mergia, J. Whang, A. Tumolo, J. Friedman, K. Hjerrild, D. Gospodarowicz, J. Fiddes (1986)
Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor.Science, 233 4763
-
P. Bőhlen, F. Esch, A. Baird, D. Gospodarowicz (1985)
Acidic fibroblast growth factor (FGF) from bovine brain: amino‐terminal sequence and comparison with basic FGF.The EMBO Journal, 4
-
B. Manger, A. Weiss, C. Weyand, J. Goronzy, J. Stobo (1985)
T cell activation: differences in the signals required for IL 2 production by nonactivated and activated T cells.Journal of immunology, 135 6
-
N. Webb, R. Chari, G. DePillis, J. Kozarich, R. Rhoads (1984)
Correction. Purification of the Messenger RNA Cap-Binding Protein Using a New Affinity MediumBiochemistry, 23
-
Y. Shing, J. Folkman, R. Sullivan, C. Butterfield, J. Murray, M. Klagsbrun (1984)
Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor.Science, 223 4642
-
M. Moenner, B. Chevallier, J. Badet, D. Barritault (1986)
Evidence and characterization of the receptor to eye-derived growth factor I, the retinal form of basic fibroblast growth factor, on bovine epithelial lens cells.Proceedings of the National Academy of Sciences of the United States of America, 83 14
-
G. Neufeld, D. Gospodarowicz (1985)
The identification and partial characterization of the fibroblast growth factor receptor of baby hamster kidney cells.The Journal of biological chemistry, 260 25
-
A. Baird, P. Mormède, P. Bőhlen (1985)
Immunoreactive fibroblast growth factor in cells of peritoneal exudate suggests its identity with macrophage-derived growth factor.Biochemical and biophysical research communications, 126 1
-
M. Sporn, A. Roberts (1985)
Autocrine growth factors and cancerNature, 313
-
E. Weber, C. Evans, J. Chang, J. Barchas (1982)
Antibodies Specific for α‐N‐Acetyl‐β‐Endorphins: Radioimmunoassays and Detection of Acetylated β‐Endorphins in Pituitary ExtractsJournal of Neurochemistry, 38
-
P. Thomas (1980)
Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.Proceedings of the National Academy of Sciences of the United States of America, 77 9
-
A. Goustin, E. Leof, G. Shipley, H. Moses (1986)
Growth factors and cancer.Cancer research, 46 3
-
J. Folkman (1986)
How is blood vessel growth regulated in normal and neoplastic tissue? G.H.A. Clowes memorial Award lecture.Cancer research, 46 2
-
D. Gospodarowicz, S. Massoglia, Jannie Cheng, G. Lui, P. Böhlen (1985)
Isolation of pituitary fibroblast growth factor by fast protein liquid chromatography (FPLC): Partial chemical and biological characterizationJournal of Cellular Physiology, 122
-
D. Gospodarowicz, G. Neufeld, Lothar Schweigerer (1986)
Molecular and biological characterization of fibroblast growth factor, an angiogenic factor which also controls the proliferation and differentiation of mesoderm and neuroectoderm derived cells.Cell differentiation, 19 1
-
J. Goding (1976)
Conjugation of antibodies with fluorochromes: modifications to the standard methods.Journal of immunological methods, 13 3-4
-
R. Lobb, J. Sasse, R. Sullivan, Y. Shing, P. D’Amore, J. Jacobs, M. Klagsbrun (1986)
Purification and characterization of heparin-binding endothelial cell growth factors.The Journal of biological chemistry, 261 4
-
R. Lobb, J. Fett (1984)
Purification of two distinct growth factors from bovine neural tissue by heparin affinity chromatography.Biochemistry, 23 26
-
H. Lehrach, D. Diamond, J. Wozney, H. Boedtker (1977)
RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination.Biochemistry, 16 21
-
B. Olwin, S. Hauschka (1986)
Identification of the fibroblast growth factor receptor of Swiss 3T3 cells and mouse skeletal muscle myoblasts.Biochemistry, 25 12
-
D. Gospodarowicz, S. Massoglia, J. Cheng, D. Fujii (1986)
Effect of fibroblast growth factor and lipoproteins on the proliferation of endothelial cells derived from bovine adrenal cortex, brain cortex, and corpus luteum capillariesJournal of Cellular Physiology, 127
-
D. Gospodarowicz, Jannie Cheng, G. Lui, Andrew BAIRDt, Peter BOHLENTt (1984)
Isolation of brain fibroblast growth factor by heparin-Sepharose affinity chromatography: identity with pituitary fibroblast growth factor.Proceedings of the National Academy of Sciences of the United States of America, 81 22
-
P. Auron, A. Webb, L. Rosenwasser, S. Mucci, A. Rich, S. Wolff, C. Dinarello (1984)
Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.Proceedings of the National Academy of Sciences of the United States of America, 81 24
-
C. March, B. Mosley, A. Larsen, D. Cerretti, G. Braedt, V. Price, S. Gillis, C. Henney, S. Kronheim, K. Grabstein, P. Conlon, T. Hopp, D. Cosman (1985)
Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAsNature, 315
- Publisher
- Springer Journals
- Copyright
- Copyright © 1987 by Nature Publishing Group
- Subject
- Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
- ISSN
- 0028-0836
- eISSN
- 1476-4687
- DOI
- 10.1038/325257a0
- Publisher site
- See Article on Publisher Site
Abstract
Angiogenesis, the formation of new capillaries, which is observed in embryonic and injured tissue and is particularly prominent in the vicinity of solid tumours1, involves the migration and proliferation of capillary endothelial cells. It is probably triggered by agents, such as basic fibroblast growth factor (bFGF), thought to be released from tissues adjacent to proliferating capillaries1. As well as being a potent inducer of cell division in capillary endothelial cells in vitro, bFGF can act as an angiogenic agent in vivo 2. It is present in a wide variety of richly vascularized tissues including brain, pituitary, retina, adrenal gland, kidney, corpus luteum, placenta and various tumours1–3. So far, however, the normal bFGF-producing cell species in these tissues have not been identified2,4. We report here that capillary endothelial cells express the bFGF gene, that they produce and release bFGF and that bFGF derived from them can stimulate the proliferation of capillary endothelial cells. We conclude that bFGF can act as a self-stimulating growth factor for capillary endothelial cells, and that it is possible that the formation of new capillaries is induced by capillary endothelial cells themselves.
Journal
Nature – Springer Journals
Published: Jan 15, 1987