/lp/oxford-university-press/dna-repair-synthesis-in-individuals-with-and-without-a-family-history-N9vbblIwmB
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- Publisher
- Oxford University Press
- Copyright
- © IRL Press
- ISSN
- 0143-3334
- eISSN
- 1460-2180
- DOI
- 10.1093/carcin/10.4.693
- Publisher site
- See Article on Publisher Site
Abstract
The influence of family history on DNA repair synthesis, unscheduled DNA synthesis (UDS), was assessed in volunteers with or without a family history of cancer. UDS, following treatment of mononuclear leukocytes with N-acetoxy-2-acetylaminofluorene, was measured as the incorporation of [3H] into DNA in the presence of hydroxyurea. The positive family history group (n=71) had an average of 2.4 first-degree relatives with cancer, defined as any major cancer, excluding skin cancer: 31 participants reported that cancer occurred in both their parents. The ‘no family history’ comparison group (n=29) had no family history of cancer through the second degree. There was a significant reduction in UDS in cells from individuals with family history, compared to those with no family history (P>0.002). This relationship was not explained by factors known to influence UDS, such as age, smoking or hypertension. We conclude that reduced UDS in mononuclear leukocytes is associated with a family history of any major cancer, and is not confined to a history of cancer of any single organ site. This conclusion is further supported by the observation that individuals (n=13) with parents who had an earlier onset of cancer (<60 years) also had a significantly lower DNA repair synthesis than those (n=18) whose parents had later diagnosis of cancer (>60 years).
Journal
Carcinogenesis – Oxford University Press
Published: Apr 1, 1989