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mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival

mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic... Downloaded from genesdev.cshlp.org on September 22, 2021 - Published by Cold Spring Harbor Laboratory Press mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival 1,4 1,3,4 2 1 2 Jan-Hermen Dannenberg, Gregory David, Sheng Zhong, Jaco van der Torre, Wing H. Wong, 1,5 and Ronald A. DePinho Department of Medical Oncology, Dana Farber Cancer Institute; Departments of Medicine and Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA; Department of Statistics, Stanford University, Stanford, California 94305, USA mSin3A is a core component of a large multiprotein corepressor complex with associated histone deacetylase (HDAC) enzymatic activity. Physical interactions of mSin3A with many sequence-specific transcription factors has linked the mSin3A corepressor complex to the regulation of diverse signaling pathways and associated biological processes. To dissect the complex nature of mSin3A’s actions, we monitored the impact of conditional mSin3A deletion on the developmental, cell biological, and transcriptional levels. mSin3A was shown to play an essential role in early embryonic development and in the proliferation and survival of primary, immortalized, and transformed cells. Genetic and biochemical analyses established a role for mSin3A/HDAC in p53 deacetylation and activation, although genetic deletion of p53 was not sufficient to attenuate the mSin3A null http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genes & Development Unpaywall

mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival

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Unpaywall
ISSN
0890-9369
DOI
10.1101/gad.1286905
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Abstract

Downloaded from genesdev.cshlp.org on September 22, 2021 - Published by Cold Spring Harbor Laboratory Press mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival 1,4 1,3,4 2 1 2 Jan-Hermen Dannenberg, Gregory David, Sheng Zhong, Jaco van der Torre, Wing H. Wong, 1,5 and Ronald A. DePinho Department of Medical Oncology, Dana Farber Cancer Institute; Departments of Medicine and Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA; Department of Statistics, Stanford University, Stanford, California 94305, USA mSin3A is a core component of a large multiprotein corepressor complex with associated histone deacetylase (HDAC) enzymatic activity. Physical interactions of mSin3A with many sequence-specific transcription factors has linked the mSin3A corepressor complex to the regulation of diverse signaling pathways and associated biological processes. To dissect the complex nature of mSin3A’s actions, we monitored the impact of conditional mSin3A deletion on the developmental, cell biological, and transcriptional levels. mSin3A was shown to play an essential role in early embryonic development and in the proliferation and survival of primary, immortalized, and transformed cells. Genetic and biochemical analyses established a role for mSin3A/HDAC in p53 deacetylation and activation, although genetic deletion of p53 was not sufficient to attenuate the mSin3A null

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Genes & Development – Unpaywall

Published: Jul 1, 2005

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