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LETTERS NATURE|Vol -
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- Publisher
- Springer Journals
- Copyright
- Copyright © 2005 by Nature Publishing Group
- Subject
- Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
- ISSN
- 0028-0836
- eISSN
- 1476-4687
- DOI
- 10.1038/nature03664
- Publisher site
- See Article on Publisher Site
Abstract
Analysis of pharmacological and genetic data from the US National Cancer Institute's NCI60 collection of cancer cell lines has identified a novel DNA amplification event in human melanomas. It alters MITF gene expression to promote melanoma formation, probably in cooperation with mutated BRAF, another key melanoma gene. Amplification of MITF may also help melanoma cells resist destruction by drugs. This work identifies MITF itself as a possible drug target in melanoma, and may encourage future genomics efforts to identify genetic alterations in other cancers.
Journal
Nature – Springer Journals
Published: Jul 7, 2005