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- Publisher
- Wiley
- Copyright
- Copyright © 1971 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 0022-3042
- eISSN
- 1471-4159
- DOI
- 10.1111/j.1471-4159.1971.tb03748.x
- Publisher site
- See Article on Publisher Site
Abstract
Mice were anaesthetized with nembutal and the effects of intraventricularly injected excitant amino acids on (U‐14C)acetate metabolism were investigated. The natural excitant amino acids, l‐glutamate and l‐aspartate, reduced the incorporation of 14C from (U‐14C)acetate into glutamine, GAB A and possibly alanine. The synthetic excitant amino acid, N‐methyl‐d‐aspartate caused a reduction in the incorporation of 14C from intraventricularly injected (U‐14C)acetate into all of the brain amino acids labelled by (U‐14C)acetate within 5 min. It is suggested that these effects may be due to changes in pool sizes of tricarboxylic cycle intermediates, to inhibition of acetyl‐CoA formation, or both. Differences in the metabolic effects of the synthetic and natural excitants are interpreted in terms of the uptake of the natural amino acids into glutamine‐forming pool(s) of glutamate metabolism.
Journal
Journal of Neurochemistry – Wiley
Published: Sep 1, 1971