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The Vascular Endothelium IIBiomechanical Modulation of Endothelial Phenotype: Implications for Health and Disease

The Vascular Endothelium II: Biomechanical Modulation of Endothelial Phenotype: Implications for... [The functional phenotypic plasticity of the vascular endothelium relies on the ability of individual endothelial cells to integrate and transduce both humoral and biomechanical stimuli from their surrounding environments. Increasing evidence strongly suggests that biomechanical stimulation is a critical determinant of endothelial gene expression and the functional phenotypes displayed by these cells in several pathophysiological conditions. Herein we discuss the types of biomechanical forces that endothelial cells are constantly exposed to within the vasculature, explain how these biomechanical stimuli serve as regulators of endothelial functionanddiscuss the increasing evidence that “atherosclerosis-protective” or “atherosclerosis-prone” haemodynamic environments can beimportant causative factors for atherogenesis via the differential regulation of endothelial transcriptional programmes.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

The Vascular Endothelium IIBiomechanical Modulation of Endothelial Phenotype: Implications for Health and Disease

Part of the Handbook of Experimental Pharmacology Book Series (volume 176/II)
Editors: Moncada, Salvador; Higgs, Annie
García-Cardeña, G.; Gimbrone, M. A.
The Vascular Endothelium II — Jan 1, 2006
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16 pages

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References (59)

Publisher
Springer Berlin Heidelberg
Copyright
© Springer-Verlag Berlin Heidelberg 2006
ISBN
978-3-540-36027-8
Pages
79–95
DOI
10.1007/3-540-36028-X_3
Publisher site
See Chapter on Publisher Site

Abstract

[The functional phenotypic plasticity of the vascular endothelium relies on the ability of individual endothelial cells to integrate and transduce both humoral and biomechanical stimuli from their surrounding environments. Increasing evidence strongly suggests that biomechanical stimulation is a critical determinant of endothelial gene expression and the functional phenotypes displayed by these cells in several pathophysiological conditions. Herein we discuss the types of biomechanical forces that endothelial cells are constantly exposed to within the vasculature, explain how these biomechanical stimuli serve as regulators of endothelial functionanddiscuss the increasing evidence that “atherosclerosis-protective” or “atherosclerosis-prone” haemodynamic environments can beimportant causative factors for atherogenesis via the differential regulation of endothelial transcriptional programmes.]

Published: Jan 1, 2006

Keywords: Endothelium; Atherosclerosis; Haemodynamic forces; Transcriptional programmes

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