Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/wolters-kluwer-health/induction-of-gas6-protein-in-ccl-4-induced-rat-liver-injury-and-anti-OSvW7KwUG5
References (63)
-
A. Lang, R. Schoonhoven, S. Tuvia, D. Brenner, R. Rippe (2000)
Nuclear factor κB in proliferation, activation, and apoptosis in rat hepatic stellate cellsJournal of Hepatology, 33
-
Paloma Valverde, M. Obin, A. Taylor (2004)
Role of Gas6/Axl signaling in lens epithelial cell proliferation and survival.Experimental eye research, 78 1
-
F. Demarchi, R. Verardo, B. Varnum, C. Brancolini, C. Schneider (2001)
Gas6 anti-apoptotic signaling requires NF-kappa B activation.The Journal of biological chemistry, 276 34
-
M. Yanagita, Y. Ishimoto, H. Arai, K. Nagai, Tsuyoshi Ito, T. Nakano, D. Salant, A. Fukatsu, T. Doi, T. Kita (2002)
Essential role of Gas6 for glomerular injury in nephrotoxic nephritis.The Journal of clinical investigation, 110 2
-
A. Suzuki, M. Hayashida, H. Kawano, K. Sugimoto, T. Nakano, K. Shiraki (2000)
Hepatocyte growth factor promotes cell survival from Fas‐mediated cell death in hepatocellular carcinoma cells via Akt activation and Fas‐death–inducing signaling complex suppressionHepatology, 32
-
B. Varnum, C. Young, G. Elliott, Andy Garcia, T. Bartley, Y. Fridell, R. Hunt, Geraldine Trail, C. Clogston, R. Toso, D. Yanagihara, L. Bennett, M. Sylber, L. Merewether, Alice Tseng, Eva Escobar, E. Liu, H. Yamane (1995)
Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6Nature, 373
-
A. Gressner (1995)
Cytokines and cellular crosstalk involved in the activation of fat-storing cells.Journal of hepatology, 22 2 Suppl
-
Toru Nakano, Y. Ishimoto, J. Kishino, Masato Umeda, Keizō Inoue, K. Nagata, K. Ohashi, K. Mizuno, H. Arita (1997)
Cell Adhesion to Phosphatidylserine Mediated by a Product of Growth Arrest-specific Gene 6*The Journal of Biological Chemistry, 272
-
G. Michalopoulos, M. Defrances (1997)
Liver Regeneration, 276
-
R. Scott, E. McMahon, Shannon Pop, E. Reap, R. Caricchio, P. Cohen, H. Earp, G. Matsushima (2001)
Phagocytosis and clearance of apoptotic cells is mediated by MERNature, 411
-
A. Gressner (1998)
The cell biology of liver fibrogenesis – an imbalance of proliferation, growth arrest and apoptosis of myofibroblastsCell and Tissue Research, 292
-
Kazuyoshi Kon, K. Ikejima, M. Hirose, Mutsuko Yoshikawa, N. Enomoto, T. Kitamura, Y. Takei, N. Sato (2002)
Pioglitazone prevents early-phase hepatic fibrogenesis caused by carbon tetrachloride.Biochemical and biophysical research communications, 291 1
-
M. Yanagita, K. Ishii, H. Ozaki, H. Arai, Toru Nakano, K. Ohashi, K. Mizuno, Toru Kita, T. Doi (1999)
Mechanism of inhibitory effect of warfarin on mesangial cell proliferation.Journal of the American Society of Nephrology : JASN, 10 12
-
Yanagita (1999)
2503J Am Soc Nephrol., 10
-
H. Schulze‐Bergkamen, D. Brenner, A. Krueger, Dorothee Suess, S. Fas, C. Frey, A. Dax, D. Zink, P. Büchler, Martina Müller, P. Krammer (2004)
Hepatocyte growth factor induces Mcl‐1 in primary human hepatocytes and inhibits CD95‐mediated apoptosis via AktHepatology, 39
-
K. Ohashi, K. Mizuno, K. Kuma, T. Miyata, Toshikazu Nakamura (1994)
Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain.Oncogene, 9 3
-
Wen-rong Gong, A. Pecci, S. Roth, B. Lahme, M. Beato, A. Gressner (1998)
Transformation‐dependent susceptibility of rat hepatic stellate cells to apoptosis induced by soluble fas ligandHepatology, 28
-
J. Dudás, B. Saile, Hamudi El-Armouche, Isabella Aprigliano, G. Ramadori (2003)
Endoreplication and polyploidy in primary culture of rat hepatic stellate cellsCell and Tissue Research, 313
-
Goruppi (1996)
471Oncogene., 12
-
Gressner (1995)
28J Hepatol., 22
-
S. Dormady, X. Zhang, R. Basch (2000)
Hematopoietic progenitor cells grow on 3T3 fibroblast monolayers that overexpress growth arrest-specific gene-6 (GAS6).Proceedings of the National Academy of Sciences of the United States of America, 97 22
-
J. O’Bryan, '. Frye, P. Cogswell, A. Neubauer, Barry Kitch, C. Prokop, R. Espinosa, M. Beau, H. Earp, Edison LIUl (1991)
axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinaseMolecular and Cellular Biology, 11
-
(1993)
The cellular basis of fibrosis -
A. Canbay, P. Taimr, Natalie Torok, H. Higuchi, S. Friedman, G. Gores (2003)
Apoptotic Body Engulfment by a Human Stellate Cell Line Is ProfibrogenicLaboratory Investigation, 83
-
D. Graham, T. Dawson, David, Mullaney, H. Snodgrass, H. Earp, Ed G, Pharmacology D, H. El, Medicine
Cloning and Mrna Expression Analysis of a Novel Human Protooncogene, C-merr -
D. Couchie, Fouad Lafdil, N. Martin‐Garcia, Y. Laperche, E. Zafrani, P. Mavier (2005)
Expression and role of Gas6 protein and of its receptor Axl in hepatic regeneration from oval cells in the rat.Gastroenterology, 129 5
-
M. Allen, Chan Zeng, Kristina Schneider, Xiaoyan Xiong, M. Meintzer, Paola Bellosta, Claudio Basilico, Brian Varnum, Kim Heidenreich, M. Wierman (1999)
Growth arrest-specific gene 6 (Gas6)/adhesion related kinase (Ark) signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular signal-regulated kinase (ERK) and Akt.Molecular endocrinology, 13 2
-
A. Planagumà, J. Clària, R. Miquel, Marta López-Parra, E. Titos, Jaime Masferrer, V. Arroyo, Joan Rodé (2005)
The selective cyclooxygenase‐2 inhibitor SC‐236 reduces liver fibrosis by mechanisms involving non‐parenchymal cell apoptosis and PPARγ activationThe FASEB Journal, 19
-
S. Kliewer, T. Willson (1998)
The nuclear receptor PPARγ - Bigger than fatCurrent Opinion in Genetics & Development, 8
-
S. Kliewer, T. Willson (1998)
The nuclear receptor PPARgamma - bigger than fat.Current opinion in genetics & development, 8 5
-
F. Demarchi, R. Verardo, B. Varnum, C. Brancolini, C. Schneider (2001)
Gas6 Anti-apoptotic Signaling Requires NF-κB Activation*The Journal of Biological Chemistry, 276
-
Manfioletti (1993)
4976Mol Cell Biol., 13
-
Yanagita (2002)
239J Clin Invest., 110
-
M. Melaragno, D. Wuthrich, Veronica Poppa, D. Gill, V. Lindner, B. Berk, M. Corson (1998)
Increased expression of Axl tyrosine kinase after vascular injury and regulation by G protein-coupled receptor agonists in rats.Circulation research, 83 7
-
O'Bryan (1991)
5016Mol Cell Biol., 11
-
V. Kalinichenko, Dibyendu Bhattacharyya, Yan Zhou, G. Gusarova, Wooram Kim, B. Shin, R. Costa (2003)
Foxf1 +/− mice exhibit defective stellate cell activation and abnormal liver regeneration following CCl4 injuryHepatology, 37
-
J. O’Bryan, Y. Fridell, R. Koski, B. Varnum, E. Liu (1995)
The Transforming Receptor Tyrosine Kinase, Axl, Is Post-translationally Regulated by Proteolytic Cleavage (*)The Journal of Biological Chemistry, 270
-
M. Yanagita, H. Arai, K. Ishii, Toru Nakano, K. Ohashi, K. Mizuno, B. Varnum, A. Fukatsu, T. Doi, T. Kita (2001)
Gas6 regulates mesangial cell proliferation through Axl in experimental glomerulonephritis.The American journal of pathology, 158 4
-
K. Neubauer, S. Eichhorst, T. Wilfling, M. Buchenau, Liuwan Xia, G. Ramadori (1998)
Sinusoidal intercellular adhesion molecule-1 up-regulation precedes the accumulation of leukocyte function antigen-1-positive cells and tissue necrosis in a model of carbontetrachloride-induced acute rat liver injury.Laboratory investigation; a journal of technical methods and pathology, 78 2
-
M. Alison (2003)
Characterization of the Differentiation Capacity of Rat-Derived Hepatic Stem CellsSEMINARS IN LIVER DISEASE, 23
-
Graham (1994)
647Cell Growth Differ., 5
-
S. Goruppi, E. Ruaro, C. Schneider (1996)
Gas6, the ligand of Axl tyrosine kinase receptor, has mitogenic and survival activities for serum starved NIH3T3 fibroblasts.Oncogene, 12 3
-
J. Savill, I. Dransfield, C. Gregory, C. Haslett (2002)
A blast from the past: clearance of apoptotic cells regulates immune responsesNature Reviews Immunology, 2
-
P. Chomczyński, N. Sacchi (1987)
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.Analytical biochemistry, 162 1
-
S. Friedman (1993)
The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment StrategiesThe New England Journal of Medicine, 328
-
Jonas Stenhoff, B. Dahlbäck, S. Hafizi (2004)
Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts.Biochemical and biophysical research communications, 319 3
-
I. Hasanbasic, J. Cuerquis, B. Varnum, M. Blostein (2004)
Intracellular signaling pathways involved in Gas6-Axl-mediated survival of endothelial cells.American journal of physiology. Heart and circulatory physiology, 287 3
-
G. Manfioletti, C. Brancolini, G. Avanzi, C. Schneider (1993)
The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascadeMolecular and Cellular Biology, 13
-
Ohashi (1994)
699Oncogene., 9
-
H. Tsutsui, K. Matsui, N. Kawada, Y. Hyodo, N. Hayashi, H. Okamura, K. Higashino, K. Nakanishi (1997)
IL-18 accounts for both TNF-alpha- and Fas ligand-mediated hepatotoxic pathways in endotoxin-induced liver injury in mice.Journal of immunology, 159 8
-
A. Lang, R. Schoonhoven, S. Tuvia, D. Brenner, R. Rippe (2000)
Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells.Journal of hepatology, 33 1
-
Toru Nakano, K. Higashino, N. Kikuchi, J. Kishino, K. Nomura, H. Fujita, O. Ohara, H. Arita (1995)
Vascular Smooth Muscle Cell-derived, Gla-containing Growth-potentiating Factor for Ca-mobilizing Growth Factors (*)The Journal of Biological Chemistry, 270
-
Neubauer (1998)
185Lab Invest., 78
-
Tsutsui (1997)
3961J Immunol., 159
-
J. Lee, K. Lee, Y. Paik, Young Park, K. Han, C. Chon, Y. Moon (2003)
Apoptosis of hepatic stellate cells in carbon tetrachloride induced acute liver injury of the rat: analysis of isolated hepatic stellate cells.Journal of hepatology, 39 6
-
P. Heldin (1996)
Biosynthesis and degradation of hyaluronan by nonparenchymal liver cells during liver regenerationHepatology, 23
-
Liying Li, Jiangchuan Tao, J. Davaille, Chloé Féral, A. Mallat, Jennifer Rieusset, Hubert Vidal, S. Lotersztajn (2001)
15-deoxy-Delta 12,14-prostaglandin J2 induces apoptosis of human hepatic myofibroblasts. A pathway involving oxidative stress independently of peroxisome-proliferator-activated receptors.The Journal of biological chemistry, 276 41
-
G. Xiao, M. Jeffers, A. Bellacosa, Y. Mitsuuchi, G. Woude, J. Testa (2001)
Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways.Proceedings of the National Academy of Sciences of the United States of America, 98 1
-
R. Loeser, B. Varnum, C. Carlson, M. Goldring, E. Liu, S. Sadiev, T. Kute, R. Wallin (1997)
Human chondrocyte expression of growth-arrest-specific gene 6 and the tyrosine kinase receptor axl: potential role in autocrine signaling in cartilage.Arthritis and rheumatism, 40 8
-
Couchie Couchie, Lafdil Lafdil, Martin Martin, Laperche Laperche, Zafrani Zafrani, Mavier Mavier (2005)
Expression and role of growth arrest‐pecific gene 6 protein and of its receptor axl in hepatic regeneration from oval cellsGastroenterology., 129
-
B. Saile, T. Knittel, N. Matthes, Peter Schott, G. Ramadori (1997)
CD95/CD95L-mediated apoptosis of the hepatic stellate cell. A mechanism terminating uncontrolled hepatic stellate cell proliferation during hepatic tissue repair.The American journal of pathology, 151 5
-
Saile (1997)
1265Am J Pathol., 151
-
B. Saile, N. Matthes, K. Neubauer, C. Eisenbach, Hammoudeh El-Armouche, J. Dudas, G. Ramadori (2002)
Rat liver myofibroblasts and hepatic stellate cells differ in CD95-mediated apoptosis and response to TNF-alpha.American journal of physiology. Gastrointestinal and liver physiology, 283 2
- Publisher
- Wolters Kluwer Health
- Copyright
- Copyright © 2006 American Association for the study of Liver Diseases
- ISSN
- 0270-9139
- eISSN
- 1527-3350
- DOI
- 10.1002/hep.21237
- pmid
- 16799993
- Publisher site
- See Article on Publisher Site
Abstract
The protein product of the growth arrest–specific gene 6 (Gas6) is a secreted ligand for tyrosine kinase receptors, among which Axl is the most widely distributed and displays the highest affinity for Gas6. The Gas6/Axl signaling pathway has been increasingly implicated in growth and survival processes occurring during development and tissue repair. In liver, after an acute or chronic injury, repair involves macrophages and hepatic stellate cells (HSC) activated into myofibroblastic cells (HSC/MFB), which produce cytokines and matrix proteins. We investigated the expression and the role of Gas6 and its receptor Axl in liver repair. Three days after CCl4‐induced liver injury in the rat, we detected the expression of Gas6 in ED1‐positive macrophages as well as in desmin‐positive HSC, which accumulated in injured areas. Axl, the high‐affinity receptor for Gas6, was detected in macrophages, HSC, and HSC/MFB. In vitro, expression of γ‐carboxylated Gas6 was strongly induced in HSC along with their transformation into myofibroblasts, and it exerted an anti‐apoptotic effect on both HSC and HSC/MFB mediated by the Axl/PI3‐kinase/Akt pathway. In conclusion, Gas6 is a survival factor for these cells and we suggest that Gas6, secreted by macrophages and HSC/MFB in vivo after liver injury, promotes HSC and HSC/MFB survival and might support transient HSC/MFB accumulation during liver healing. (HEPATOLOGY 2006;44:228‐239.)
Journal
Hepatology – Wolters Kluwer Health
Published: Jul 1, 2006