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Rodent model in caries research

Rodent model in caries research The rodent model of dental caries has made fundamental contributions to the understanding of the etiology, pathogenesis, and prevention of this disease. In conducting animal-based investigations, important details considered essential for successful outcome are occasionally overlooked. Adequate number of animals of appropriate age should always be included to ensure sufficient statistical power to draw valid conclusions. Attention should be paid to litter source as it is clear that litter origin may have a profound effect on the outcome. Inclusion of additive in diet may also affect eating pattern. A range of special techniques are available which can expand the role of animals in exploring the pathogenesis of dental caries. The arrival of genetically altered microorganisms along with availability of knock-out rodents offers exciting challenges to further explore the pathogenesis of this still too common disease. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Odontology Springer Journals

Rodent model in caries research

Bowen, William
Odontology , Volume 101 (1) – Nov 6, 2012
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References (46)

Publisher
Springer Journals
Copyright
Copyright © 2012 by The Society of The Nippon Dental University
Subject
Dentistry; Dentistry; Oral and Maxillofacial Surgery
ISSN
1618-1247
eISSN
1618-1255
DOI
10.1007/s10266-012-0091-0
pmid
23129523
Publisher site
See Article on Publisher Site

Abstract

The rodent model of dental caries has made fundamental contributions to the understanding of the etiology, pathogenesis, and prevention of this disease. In conducting animal-based investigations, important details considered essential for successful outcome are occasionally overlooked. Adequate number of animals of appropriate age should always be included to ensure sufficient statistical power to draw valid conclusions. Attention should be paid to litter source as it is clear that litter origin may have a profound effect on the outcome. Inclusion of additive in diet may also affect eating pattern. A range of special techniques are available which can expand the role of animals in exploring the pathogenesis of dental caries. The arrival of genetically altered microorganisms along with availability of knock-out rodents offers exciting challenges to further explore the pathogenesis of this still too common disease.

Journal

Odontology – Springer Journals

Published: Nov 6, 2012

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