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The role of nerves in the regeneration of minced skeletal muscle in adult anurans

The role of nerves in the regeneration of minced skeletal muscle in adult anurans The course of reinnervation and the effects of denervation and immobilization on muscle development were examined during the regeneration of minced muscle in anurans. Reinnervation occurs in the second week, at the time of myotube formation and differentiation. At the end of thirty days, nerves are plentiful and extensively distributed within the regenerating muscle. Cholinesterase activity within the regenerated muscle cannot be demonstrated at this time. Denervated regenerates develop normally during the first two weeks, but, thereafter, the young muscle fibers exhibit signs of degeneration and retarded growth. Denervated regenerates become fibrotic and contain few muscle fibers at the end of four weeks. Regenerates from muscles denervated prior to mincing show an accelerated appearance of presumptive myoblasts in the first week, but despite this precocious development, these denervated regenerates become regressive. On the other hand, the effect of disuse on muscle regeneration is not detrimental; the fibers of reinnervated but immobilized regenerates develop normally and do not become degenerative. These results suggest that nerves are unnecessary for the early myogenic processes of proliferation and fusion, but are essential to later stages of growth, maturation and maintenance of the regenerated muscle fibers. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology Wiley

The role of nerves in the regeneration of minced skeletal muscle in adult anurans

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References (28)

Publisher
Wiley
Copyright
"Copyright © 1974 Wiley Subscription Services, Inc., A Wiley Company"
ISSN
1932-8486
eISSN
1932-8494
DOI
10.1002/ar.1091790110
pmid
4821358
Publisher site
See Article on Publisher Site

Abstract

The course of reinnervation and the effects of denervation and immobilization on muscle development were examined during the regeneration of minced muscle in anurans. Reinnervation occurs in the second week, at the time of myotube formation and differentiation. At the end of thirty days, nerves are plentiful and extensively distributed within the regenerating muscle. Cholinesterase activity within the regenerated muscle cannot be demonstrated at this time. Denervated regenerates develop normally during the first two weeks, but, thereafter, the young muscle fibers exhibit signs of degeneration and retarded growth. Denervated regenerates become fibrotic and contain few muscle fibers at the end of four weeks. Regenerates from muscles denervated prior to mincing show an accelerated appearance of presumptive myoblasts in the first week, but despite this precocious development, these denervated regenerates become regressive. On the other hand, the effect of disuse on muscle regeneration is not detrimental; the fibers of reinnervated but immobilized regenerates develop normally and do not become degenerative. These results suggest that nerves are unnecessary for the early myogenic processes of proliferation and fusion, but are essential to later stages of growth, maturation and maintenance of the regenerated muscle fibers.

Journal

The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology – Wiley

Published: May 1, 1974

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