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Who's afraid of epistasis?

Who's afraid of epistasis? © 1996 Nature Publishing Group http://www.nature.com/naturegenetics news &views 1 1 2 3 Wayne N. Frankel & Nicholas J. Schork , , The Jackson Two papers contributed by Demant many forms of epistasis, each of for genome scan investigations Laboratory, 600 and colleagues in this issue of which relates to a particular way in assess the significance of only the Main Street, Bar Nature Genetics illustrate nicely that which genes can interact . main effects of potential trait loci. Harbor, Maine where complex genetic traits loom, Although a few discussions and This is certainly the case for the 04609-1500, USA 2 epistasis is not far behind • • Epista­ examples of epistasis have appeared strategies implemented in the pop­ Department of Epidemiology and sis is an age-old phenomenon that in the recent literature, they are ular human linkage analysis com­ Biostatistics and 5 10 resurfaces from time to time in the generally few and far between - . puter packages like LINKAGE, Department of literature but has never really This is more than a little surprising SAGE, MENDEL, MAPMAKER/ Genetics, Case received the attention it deserves. since epistasis is thought to play a SIBS, GENEHUNTER and APM, as Western Reserve http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Genetics Springer Journals

Who's afraid of epistasis?

Frankel, Wayne N.; Schork, Nicholas J.
Nature Genetics , Volume 14 (4) – Dec 1, 1996
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References (27)

Publisher
Springer Journals
Copyright
Copyright © 1996 by Nature Publishing Group
Subject
Biomedicine; Biomedicine, general; Human Genetics; Cancer Research; Agriculture; Gene Function; Animal Genetics and Genomics
ISSN
1061-4036
eISSN
1546-1718
DOI
10.1038/ng1296-371
Publisher site
See Article on Publisher Site

Abstract

© 1996 Nature Publishing Group http://www.nature.com/naturegenetics news &views 1 1 2 3 Wayne N. Frankel & Nicholas J. Schork , , The Jackson Two papers contributed by Demant many forms of epistasis, each of for genome scan investigations Laboratory, 600 and colleagues in this issue of which relates to a particular way in assess the significance of only the Main Street, Bar Nature Genetics illustrate nicely that which genes can interact . main effects of potential trait loci. Harbor, Maine where complex genetic traits loom, Although a few discussions and This is certainly the case for the 04609-1500, USA 2 epistasis is not far behind • • Epista­ examples of epistasis have appeared strategies implemented in the pop­ Department of Epidemiology and sis is an age-old phenomenon that in the recent literature, they are ular human linkage analysis com­ Biostatistics and 5 10 resurfaces from time to time in the generally few and far between - . puter packages like LINKAGE, Department of literature but has never really This is more than a little surprising SAGE, MENDEL, MAPMAKER/ Genetics, Case received the attention it deserves. since epistasis is thought to play a SIBS, GENEHUNTER and APM, as Western Reserve

Journal

Nature Genetics – Springer Journals

Published: Dec 1, 1996

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