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Intercommunication between mammalian oocytes and companion somatic cells

Intercommunication between mammalian oocytes and companion somatic cells Cellular interactions in the mammalian ovarian follicle between its germ‐line and somatic cell components are crucial for its development and function. These interactions are mediated by both membrane gap junctions and paracrine factors. Somatic cell‐to‐oocyte communication is essential for oocyte growth and the regulation of meiotic maturation. In particular, granulosa cells provide nutrients and molecular signals that regulate oocyte development. Oocytes, on the other hand, promote the organization of the follicle, the proliferation of granulosa cells, and the differentiation and function of cumulus cells, a subset of granulosa cells. Determining the nature of the oocyte‐to‐granulosa cell signals remains a key challenge for future work. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png BioEssays Wiley

Intercommunication between mammalian oocytes and companion somatic cells

BioEssays , Volume 13 (11) – Nov 1, 1991

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References (54)

Publisher
Wiley
Copyright
Copyright © 1991 Cambridge University Press
ISSN
0265-9247
eISSN
1521-1878
DOI
10.1002/bies.950131105
pmid
1772412
Publisher site
See Article on Publisher Site

Abstract

Cellular interactions in the mammalian ovarian follicle between its germ‐line and somatic cell components are crucial for its development and function. These interactions are mediated by both membrane gap junctions and paracrine factors. Somatic cell‐to‐oocyte communication is essential for oocyte growth and the regulation of meiotic maturation. In particular, granulosa cells provide nutrients and molecular signals that regulate oocyte development. Oocytes, on the other hand, promote the organization of the follicle, the proliferation of granulosa cells, and the differentiation and function of cumulus cells, a subset of granulosa cells. Determining the nature of the oocyte‐to‐granulosa cell signals remains a key challenge for future work.

Journal

BioEssaysWiley

Published: Nov 1, 1991

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