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- Publisher
- Springer Journals
- Copyright
- Copyright © 2002 by Springer-Verlag
- Subject
- Biomedicine; Pharmacology/Toxicology; Neurosciences
- ISSN
- 0028-1298
- eISSN
- 1432-1912
- DOI
- 10.1007/s00210-002-0599-x
- pmid
- 12382079
- Publisher site
- See Article on Publisher Site
Abstract
Inhibition of the cardiac Kv1.5 channel, the molecular base for the human cardiac ultrarapid delayed rectifier potassium current (I Kur), is considered a new promising atrial selective antiarrhythmic concept since this channel is presumed to contribute to atrial but not ventricular repolarization in the human heart. In a previous study in pigs we found clear baseline differences in refractoriness between left and right atrium with shorter effective refractory periods (ERPs) of the left atrium associated with a high left atrial vulnerability for tachyarrhythmias. In this newly established model we compared atrial and ventricular effects of two novel I Kur blockers, S9947 and S20951, with the I Kr blockers dofetilide, azimilide, ibutilide and d,l-sotalol. In pentobarbital anesthetized pigs (n=45) we determined ERPs in the free walls of both atria with the S1-S2-stimulus method at three basic cycle lengths (BCL 240/300/400 ms) and QTc-intervals. The incidence of atrial tachyarrhythmias triggered by the S2-extrastimulus of the left atrium was evaluated (referred to as left atrial vulnerability).
Journal
Naunyn-Schmiedeberg's Archives of Pharmacology – Springer Journals
Published: Nov 5, 2002