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The uptake, transport and fate of exogenous protein in undamaged cranial motor and neurosecretory neurons in mice have been investigated using enzyme cytochemical techniques for horseradish peroxidase (HRP) and lysosomal acid hydrolases. Labeling of these neuronal perikarya with HRP is accomplished by retrograde axoplasmic transport from their axon terminals following vascular injection of the protein or by direct somal‐dendritic uptake subsequent to cerebral ventriculo‐cisternal perfusion of peroxidase. Axon terminals of neurosecretory neurons innervating the posterior pituitary gland and those of cranial motoneurons can remain unexposed to HRP administered intraventricularly and, therefore, cannot directly incorporate the protein.
The Journal of Comparative Neurology – Wiley
Published: Jan 1, 1979
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