Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/wolters-kluwer-health/ischemia-reperfusion-injury-in-rat-fatty-liver-role-of-nutritional-QGXTZb7Tvg
References (43)
-
S. Lindell, T. Hansen, M. Rankin, R. Danielewicz, F. Belzer, J. Southard (1996)
Donor nutritional status--a determinant of liver preservation injury.Transplantation, 61 2
-
B. Husberg, Y. Genyk, G. Klintmalm (1994)
A new rat model for studies of the ischemic injury after transplantation of fatty livers: improvement after postoperative administration of prostaglandin.Transplantation, 57 3
-
Kenichi Hakamada, M. Sasaki, Katsuro Takahashi, Yutaka Umehara, M. Konn (1997)
Sinusoidal flow block after warm ischemia in rats with diet-induced fatty liver.The Journal of surgical research, 70 1
-
J. Mårtensson, A. Meister (1989)
Mitochondrial damage in muscle occurs after marked depletion of glutathione and is prevented by giving glutathione monoester.Proceedings of the National Academy of Sciences of the United States of America, 86 2
-
Hoyumpa (1975)
10.1007/BF01070758Dig Dis Sci, 20
-
Cywes (1992)
10.1097/00000658-199209000-00003Ann Surg, 216
-
W. Gao, H. Connor, J. Lemasters, R. Mason, R. Thurman (1995)
Primary nonfunction of fatty livers produced by alcohol is associated with a new, antioxidant-insensitive free radical species.Transplantation, 59 5
-
Xing-Xi Peng, R. Currin, R. Thurman, J. Lemasters (1995)
PROTECTION BY PENTOXIFYLLINE AGAINST NORMOTHERMIC LIVER ISCHEMIA/REPERFUSION IN RATSTransplantation, 59
-
A. Gasbarrini, A. Borle, H. Farghali, P. Caraceni, D. Thiel (1993)
Fasting enhances the effects of anoxia on ATP, Cai2+ and cell injury in isolated rat hepatocytes.Biochimica et biophysica acta, 1178 1
-
R. Adam, M. Reynés, M. Johann, M. Morino, İ. Astarcıoğlu, I. Kafetzis, D. Castaing, H. Bismuth (1991)
The outcome of steatotic grafts in liver transplantation.Transplantation proceedings, 23 1 Pt 2
-
D Keppler, K Decker (1986)
Methods of Enzymatic Analysis, 6
-
PW Hochachka, JM Castellini, RD Hill, RC Schneider, JL Bengston, SE Hill, GC Liggins (1988)
Protective metabolic mechanisms during liver ischemia: transferable lessons from long‐diving animals, 84
-
M. Fisher, J. Rankin (1977)
Alcohol and the LiverRevista Clinica Espanola, 131
-
C. Lieber (1994)
Alcohol and the liver: 1994 update.Gastroenterology, 106 4
-
W. Helton (1993)
Effect of intraportal glucose infusion on hepatic glycogen content and degradation, and outcome of liver transplantation.JPEN. Journal of parenteral and enteral nutrition, 17 2
-
Kenichi Teramoto, John Bowers, J. Kruskal, Melvin Clouse (1993)
Hepatic microcirculatory changes after reperfusion in fatty and normal liver transplantation in the rat.Transplantation, 56 5
-
N. Johnson (1958)
Multivariate AnalysisNature, 182
-
K. Teramoto, J. Bowers, U. Khettry, J. Palombo, M. Clouse (1993)
A rat fatty liver transplant model.Transplantation, 55 4
-
(1991)
L’ischemie du foie de plus d’une heure est-elle un facteur de gravitè des hepatectomies? A propos de 19 cas. 1991;117:351356 -
P. Caraceni, H. Ryu, V. Subbotin, N. Maria, A. Colantoni, Leonard Roberts, F. Trevisani, M. Bernardi, D. Thiel (1997)
Rat hepatocytes isolated from alcohol‐induced fatty liver have an increased sensitivity to anoxic injuryHepatology, 25
-
A. D’ALESSANDRO, M. Kalayoglu, H. Sollinger, R. Hoffmann, A. Reed, S. Knechtle, J. Pirsch, Hafez Gr, D. Lorentzen, F. Belzer (1991)
The predictive value of donor liver biopsies for the development of primary nonfunction after orthotopic liver transplantation.Transplantation, 51 1
-
H. Sadamori, T. Yagi, K. Orita (1995)
THE EFFECTS OF NUTRITIONAL REPLETION ON DONORS FOR LIVER TRANSPLANTATION IN PIGSTransplantation, 60
-
K. Kawano, Yang Kim, K. Kaketani, Michio Kobayashi (1989)
THE BENEFICIAL EFFECT OF CYCLOSPORINE ON LIVER ISCHEMIA IN RATSTransplantation, 48
-
J. Pruim, W. Woerden, E. Knol, I. Klompmaker, K. Bruijn, G. Persijn, M. Slooff (1989)
Donor data in liver grafts with primary non-function--a preliminary analysis by the European Liver Registry.Transplantation proceedings, 21 1 Pt 2
-
Hochachka (1988)
10.1007/BF00235195Mol Cell Biochem, 84
-
S. Strasberg, T. Howard, E. Molmenti, M. Hertl (1994)
Selecting the donor liver: Risk factors for poor function after orthotopic liver transplantationHepatology, 20
-
Barry Rosser, G. Gores (1995)
Liver cell necrosis: cellular mechanisms and clinical implications.Gastroenterology, 108 1
-
W. Schneider, A. Greco (1971)
Incorporation of pyrimidine deoxyribonucleosides into liver lipids and other components.Biochimica et biophysica acta, 228 3
-
B. Bradford, M. Marotto, J. Lemasters, R. Thurman (1986)
New, simple models to evaluate zone-specific damage due to hypoxia in the perfused rat liver: time course and effect of nutritional state.The Journal of pharmacology and experimental therapeutics, 236 1
-
R. Sumimoto, J. Southard, F. Belzer (1993)
Livers from fasted rats acquire resistance to warm and cold ischemia injury.Transplantation, 55 4
-
P. Simplicio, R. Rossi, S. Falcinelli, R. Ceserani, M. Formento (1997)
Antioxidant status in various tissues of the mouse after fasting and swimming stressEuropean Journal of Applied Physiology and Occupational Physiology, 76
-
A. Hui, S. Kawasaki, M. Makuuchi, J. Nakayama, T. Ikegami, S. Miyagawa (1994)
Liver injury following normothermic ischemia in steatotic rat liverHepatology, 20
-
R. Markin, J. Wisecarver, S. Radio, R. Stratta, K. Hirst, B. Shaw (1993)
FROZEN SECTION EVALUATION OF DONOR LIVERS BEFORE TRANSPLANTATIONTransplantation, 56
-
AM Hoyumpa, HL Greene, GL Dunn, SDD Shenker (1975)
Fatty liver: biochemical and clinical consideration, 20
-
A. Ghoshal, E. Farber (1993)
Choline deficiency, lipotrope deficiency and the development of liver disease including liver cancer: a new perspective.Laboratory investigation; a journal of technical methods and pathology, 68 3
-
R. Cywes, P. Greig, Glynn Morgan, J. Sanabria, P. Clavien, P. Harvey, S. Strasberg (1992)
Rapid donor liver nutritional enhancement in a large animal modelHepatology, 16
-
Claude Huguet, A. Gavelli, Chieco Pa, S. Bona, J. Harb, Joseph Jm, J. Jobard, M. Gramaglia, M. Lasserre (1992)
Liver ischemia for hepatic resection: where is the limit?Surgery, 111 3
-
B. Koneru, M. Reddy, A. Torre, D. Patel, T. Ippolito, R. Ferrante (1995)
Studies of hepatic warm ischemia in the obese Zucker rat.Transplantation, 59 7
-
F. Trevisani, A. Colantoni, P. Caraceni, D. Thiel (1996)
The use of donor fatty liver for liver transplantation: a challenge or a quagmire?Journal of hepatology, 24 1
-
H. Nakano, H. Nagasaki, A. Barama, K. Boudjema, D. Jaeck, K. Kumada, M. Tatsuno, Yeng Baek, Naoyasu Kitamura, Takao Suzuki, M. Yamaguchi (1997)
The effects of N‐acetylcysteine and anti‐intercellular adhesion molecule‐1 monoclonal antibody against ischemia‐reperfusion injury of the rat steatotic liver produced by a choline‐methionine‐deficient dietHepatology, 26
-
C Huguet, A Gavelli, J Harb, R Roger‐Clement, D De Millo, M Lasserre, MT McNamara (1991)
L'ischemie du foie de plus d'une heure est‐elle un facteur de gravitè des hepatectomies?, 117
-
R. Ploeg, A. D’ALESSANDRO, S. Knechtle, M. Stegall, J. Pirsch, R. Hoffmann, T. Sasaki, H. Sollinger, F. Belzer, M. Kalayoglu (1993)
Risk factors for primary dysfunction after liver transplantation--a multivariate analysis.Transplantation, 55 4
-
H. Sankary, P. Foster, E. Brown, A. Bhattachyaryya, J. Williams (1992)
Relevance of the nutritional status of donors in viability of transplanted hepatic allografts.Transplantation, 54 1
- Publisher
- Wolters Kluwer Health
- Copyright
- Copyright © 1999 Wiley Subscription Services
- ISSN
- 0270-9139
- eISSN
- 1527-3350
- DOI
- 10.1002/hep.510290407
- pmid
- 10094958
- Publisher site
- See Article on Publisher Site
Abstract
Fatty livers are more sensitive to the deleterious effects of ischemia‐reperfusion than normal livers. Nutritional status greatly modulates this injury in normal livers, but its role in the specific setting of fatty liver is unknown. This study aimed to determine the effect of nutritional status on warm ischemia‐reperfusion injury in rat fatty livers. Fed and fasted rats with normal or fatty liver induced by a choline deficient diet underwent 1 hour of lobar ischemia and reperfusion. Rat survival was determined for 7 days. Serum transaminases, liver histology and cell ultrastructure were assessed before and after ischemia, and at 30 minutes, 2 hours, 8 hours, and 24 hours after reperfusion. Survival was also determined in fatty fasted rats supplemented with glucose before surgery. The preischemic hepatic glycogen was measured in all groups. Whereas survival was similar in fasted and fed rats with normal liver (90% vs. 100%), fasting dramatically reduced survival in rats with fatty liver (14% vs. 64%, P < .01). Accordingly, fasting and fatty degeneration had a synergistic effect in exacerbating liver injury. Mitochondrial damage was a predominant feature of ultrastructural hepatocyte injury in fasted fatty livers. Glucose supplementation partially prevented the fasting‐induced depletion of glycogen and improved the 7‐day rat survival to 45%. These data indicate that rat fatty livers exposed to normothermic ischemia‐reperfusion injury are much more sensitive to fasting than histologically normal livers. Because glucose supplementation improves both the hepatic glycogen stores and the rat survival, a nutritional repletion procedure may be part of a treatment strategy aimed to prevent ischemia‐reperfusion injury in fatty livers
Journal
Hepatology – Wolters Kluwer Health
Published: Jan 1, 1999