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Accurate liver T * 2 measurement of iron overload: A simulations investigation and in vivo study

Accurate liver T * 2 measurement of iron overload: A simulations investigation and in vivo study Purpose To investigate the accuracy of T *2 liver iron quantification using different curve‐fitting models under varying acquisition conditions, and to compare in iron‐overloaded patients the reliability of rapid T *2 measurements against approved and slower T2 protocols. Materials and Methods Simulations were conducted to assess the influence of various factors on the accuracy of T *2 measurement: curve‐fitting model, signal‐to‐noise ratio (SNR), and echo time (TE) spacing. Fifty‐four iron‐overloaded pediatric patients were assessed using a standard T2 and two variations of T *2 acquisitions. In both simulations and in vivo data, three analysis models were evaluated: monoexponential, constant offset, and truncated. Results Simulations show the truncated model provides the best accuracy but is susceptible to underestimating high iron species under low SNR or high minimum TE. In contrast, the offset model tends to overestimate but maintains the most reliable measurements across the relevant range of iron levels. Furthermore, a much lower SNR can be tolerated if the acquisition uses a low minimum TE. In vivo results confirm theoretical findings and show that T *2 measurements can be as reliable as those from approved and slower T2 protocols. Conclusion Guidelines are provided on choosing an appropriate model under specific noise conditions and acquisition schemes to ensure accurate and rapid T *2 liver iron quantification. J. Magn. Reson. Imaging 2009;30:313–320. © 2009 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Magnetic Resonance Imaging Wiley

Accurate liver T * 2 measurement of iron overload: A simulations investigation and in vivo study

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References (26)

Publisher
Wiley
Copyright
Copyright © 2009 Wiley‐Liss, Inc.
ISSN
1053-1807
eISSN
1522-2586
DOI
10.1002/jmri.21835
pmid
19629985
Publisher site
See Article on Publisher Site

Abstract

Purpose To investigate the accuracy of T *2 liver iron quantification using different curve‐fitting models under varying acquisition conditions, and to compare in iron‐overloaded patients the reliability of rapid T *2 measurements against approved and slower T2 protocols. Materials and Methods Simulations were conducted to assess the influence of various factors on the accuracy of T *2 measurement: curve‐fitting model, signal‐to‐noise ratio (SNR), and echo time (TE) spacing. Fifty‐four iron‐overloaded pediatric patients were assessed using a standard T2 and two variations of T *2 acquisitions. In both simulations and in vivo data, three analysis models were evaluated: monoexponential, constant offset, and truncated. Results Simulations show the truncated model provides the best accuracy but is susceptible to underestimating high iron species under low SNR or high minimum TE. In contrast, the offset model tends to overestimate but maintains the most reliable measurements across the relevant range of iron levels. Furthermore, a much lower SNR can be tolerated if the acquisition uses a low minimum TE. In vivo results confirm theoretical findings and show that T *2 measurements can be as reliable as those from approved and slower T2 protocols. Conclusion Guidelines are provided on choosing an appropriate model under specific noise conditions and acquisition schemes to ensure accurate and rapid T *2 liver iron quantification. J. Magn. Reson. Imaging 2009;30:313–320. © 2009 Wiley‐Liss, Inc.

Journal

Journal of Magnetic Resonance Imaging – Wiley

Published: Aug 1, 2009

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