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The Effect of Brain Tumors on BOLD Functional MR Imaging Activation in the Adjacent Motor Cortex: Implications for Image-guided Neurosurgery

The Effect of Brain Tumors on BOLD Functional MR Imaging Activation in the Adjacent Motor Cortex:... This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Holodny, A. I. Articles by Kalnin, A. J. Search for Related Content PubMed PubMed Citation Articles by Holodny, A. I. Articles by Kalnin, A. J. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 21:1415-1422 (8 2000) © 2000 American Society of Neuroradiology ARTICLE The Effect of Brain Tumors on BOLD Functional MR Imaging Activation in the Adjacent Motor Cortex: Implications for Image-guided Neurosurgery Andrei I. Holodny ,a , Michael Schulder a , Wen-Ching Liu a , Jonathan Wolko a , Joseph A. Maldjian a and Andrew J. Kalnin a a From the Departments of Radiology (A.I.H., W.C.L., A.J.K.) and Neurosurgery (M.S.), UMDNJ-New Jersey Medical School, Newark, NJ; UMDNJ-New Jersey Medical School, Newark, NJ (J.W.); and the Department of Radiology (J.A.M.), University of Pennsylvania, Philadelphia, Pennsylvania. BACKGROUND AND PURPOSE: Functional MR (fMR) imaging data coregistered to a neurosurgical navigation system have been proposed as guides for the resection of brain tumor in or adjacent to eloquent cortices. The purpose of this study was to compare data obtained from the side of the brain affected by tumor with the contralateral side and to determine if there are physiological limitations of fMR imaging in accurately determining the location of the primary motor cortex. METHODS: Ten patients with tumors in or directly adjacent to the motor cortex were studied with fMR imaging (finger-tapping paradigm). fMR imaging data were analyzed using multiple R values. These data were coregistered to a real-time intraoperative neurosurgical navigation system. RESULTS: Significant variability of motor cortex activation patterns was noted among individual patients. The activation volumes on the side of the tumor were significantly smaller compared with the contralateral side for all tumors not previously resected (0.66±0.47). This was most pronounced in glioblastomas (0.27±0.21). We propose that these differences were caused by a loss of autoregulation in the tumor vasculature of glioblastomas and venous effects. CONCLUSION: Notwithstanding the differences noted, the motor cortex was identified successfully in all patients. This was confirmed by intraoperative physiological identification of the motor cortex and a lack of postoperative neurologic deficit. This article has been cited by other articles: J.J. Pillai The Evolution of Clinical Functional Imaging during the Past 2 Decades and Its Current Impact on Neurosurgical Planning AJNR Am. J. Neuroradiol., February 1, 2010; 31(2): 219 - 225. Abstract Full Text PDF M. Kocak, J. L. Ulmer, M. Sahin Ugurel, W. Gaggl, and R. W. Prost Motor Homunculus: Passive Mapping in Healthy Volunteers by Using Functional MR Imaging--Initial Results1 Radiology, May 1, 2009; 251(2): 485 - 492. Abstract Full Text PDF S.C. Feldman, D. Chu, M. Schulder, M. Barry, E.-S. Cho, and W.-C. Liu The Blood Oxygen Level-Dependent Functional MR Imaging Signal Can Be Used to Identify Brain Tumors and Distinguish Them from Normal Tissue AJNR Am. J. Neuroradiol., February 1, 2009; 30(2): 389 - 395. Abstract Full Text PDF C. M. Chen, B. L. Hou, and A. I. Holodny Effect of Age and Tumor Grade on BOLD Functional MR Imaging in Preoperative Assessment of Patients with Glioma Radiology, September 1, 2008; 248(3): 971 - 978. Abstract Full Text PDF A M BLAMIRE The technology of MRI -- the next 10 years? Br. J. Radiol., August 1, 2008; 81(968): 601 - 617. Abstract Full Text PDF A. Bizzi, V. Blasi, A. Falini, P. Ferroli, M. Cadioli, U. Danesi, D. Aquino, C. Marras, D. Caldiroli, and G. Broggi Presurgical Functional MR Imaging of Language and Motor Functions: Validation with Intraoperative Electrocortical Mapping Radiology, August 1, 2008; 248(2): 579 - 589. Abstract Full Text PDF I.M. Ruff, N.M. Petrovich Brennan, K.K. Peck, B.L. Hou, V. Tabar, C.W. Brennan, and A.I. Holodny Assessment of the Language Laterality Index in Patients with Brain Tumor Using Functional MR Imaging: Effects of Thresholding, Task Selection, and Prior Surgery AJNR Am. J. Neuroradiol., March 1, 2008; 29(3): 528 - 535. Abstract Full Text PDF M. Desmurget, F. Bonnetblanc, and H. Duffau Contrasting acute and slow-growing lesions: a new door to brain plasticity Brain, April 1, 2007; 130(4): 898 - 914. Abstract Full Text PDF A. Korvenoja, E. Kirveskari, H. J. Aronen, S. Avikainen, A. Brander, J. Huttunen, R. J. Ilmoniemi, J. E. Jaaskelainen, T. Kovala, J. P. Makela, et al. Sensorimotor Cortex Localization: Comparison of Magnetoencephalography, Functional MR Imaging, and Intraoperative Cortical Mapping Radiology, October 1, 2006; 241(1): 213 - 222. Abstract Full Text PDF J. R. Petrella, L. M. Shah, K. M. Harris, A. H. Friedman, T. M. George, J. H. Sampson, J. S. Pekala, and J. T. Voyvodic Preoperative Functional MR Imaging Localization of Language and Motor Areas: Effect on Therapeutic Decision Making in Patients with Potentially Resectable Brain Tumors Radiology, September 1, 2006; 240(3): 793 - 802. Abstract Full Text PDF C.V. Salvan, J.L. Ulmer, W.M. Mueller, H.G.J. Krouwer, R.W. Prost, and G.O. Stroe Presurgical and Intraoperative Mapping of the Motor System in Congenital Truncation of the Precentral Gyrus AJNR Am. J. Neuroradiol., March 1, 2006; 27(3): 493 - 497. Abstract Full Text PDF M. J.J. Kim, A. I. Holodny, B. L. Hou, K. K. Peck, C. S. Moskowitz, D. L. Bogomolny, and P. H. Gutin The Effect of Prior Surgery on Blood Oxygen Level-Dependent Functional MR Imaging in the Preoperative Assessment of Brain Tumors AJNR Am. J. Neuroradiol., September 1, 2005; 26(8): 1980 - 1985. Abstract Full Text PDF A. Krainik, M. Hund-Georgiadis, S. Zysset, and D. Y. von Cramon Regional Impairment of Cerebrovascular Reactivity and BOLD Signal in Adults After Stroke Stroke, June 1, 2005; 36(6): 1146 - 1152. Abstract Full Text PDF Y. Murata, K. Sakatani, Y. Katayama, N. Fujiwara, T. Hoshino, C. Fukaya, and T. Yamamoto Decreases of Blood Oxygenation Level--Dependent Signal in the Activated Motor Cortex during Functional Recovery after Resection of a Glioma AJNR Am. J. Neuroradiol., August 1, 2004; 25(7): 1242 - 1246. Abstract Full Text PDF A. Krainik, H. Duffau, L. Capelle, P. Cornu, A. -L. Boch, J. -F. Mangin, D. Le Bihan, C. Marsault, J. Chiras, and S. Lehericy Role of the healthy hemisphere in recovery after resection of the supplementary motor area Neurology, April 27, 2004; 62(8): 1323 - 1332. Abstract Full Text PDF J. Sailor, M. E. Meyerand, C. H. Moritz, J. Fine, L. Nelson, B. Badie, and V. M. Haughton Supplementary Motor Area Activation in Patients with Frontal Lobe Tumors and Arteriovenous Malformations AJNR Am. J. Neuroradiol., October 1, 2003; 24(9): 1837 - 1842. Abstract Full Text PDF J. L. Ulmer, H. G. Krouwer, W. M. Mueller, M.S. Ugurel, M. Kocak, and L. P. Mark Pseudo-Reorganization of Language Cortical Function at fMR Imaging: A Consequence of Tumor-Induced Neurovascular Uncoupling AJNR Am. J. Neuroradiol., February 1, 2003; 24(2): 213 - 217. Abstract Full Text PDF I D Wilkinson, C A J Romanowski, D A Jellinek, J Morris, and P D Griffiths Motor functional MRI for pre-operative and intraoperative neurosurgical guidance Br. J. Radiol., February 1, 2003; 76(902): 98 - 103. Abstract Full Text PDF Y Murata, K Sakatani, Y Katayama, and C Fukaya Increase in focal concentration of deoxyhaemoglobin during neuronal activity in cerebral ischaemic patients J. Neurol. Neurosurg. Psychiatry, August 1, 2002; 73(2): 182 - 184. Abstract Full Text PDF J. H. Brannen, B. Badie, C. H. Moritz, M. Quigley, M. E. Meyerand, and V. M. Haughton Reliability of Functional MR Imaging with Word-Generation Tasks for Mapping Broca's Area AJNR Am. J. Neuroradiol., October 1, 2001; 22(9): 1711 - 1718. Abstract Full Text PDF Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

The Effect of Brain Tumors on BOLD Functional MR Imaging Activation in the Adjacent Motor Cortex: Implications for Image-guided Neurosurgery

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American Journal of Neuroradiology
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Copyright © 2010 by the American Society of Neuroradiology.
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0195-6108
eISSN
1936-959X
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Abstract

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Holodny, A. I. Articles by Kalnin, A. J. Search for Related Content PubMed PubMed Citation Articles by Holodny, A. I. Articles by Kalnin, A. J. Hotlight (NEW!) What's Hotlight? American Journal of Neuroradiology 21:1415-1422 (8 2000) © 2000 American Society of Neuroradiology ARTICLE The Effect of Brain Tumors on BOLD Functional MR Imaging Activation in the Adjacent Motor Cortex: Implications for Image-guided Neurosurgery Andrei I. Holodny ,a , Michael Schulder a , Wen-Ching Liu a , Jonathan Wolko a , Joseph A. Maldjian a and Andrew J. Kalnin a a From the Departments of Radiology (A.I.H., W.C.L., A.J.K.) and Neurosurgery (M.S.), UMDNJ-New Jersey Medical School, Newark, NJ; UMDNJ-New Jersey Medical School, Newark, NJ (J.W.); and the Department of Radiology (J.A.M.), University of Pennsylvania, Philadelphia, Pennsylvania. BACKGROUND AND PURPOSE: Functional MR (fMR) imaging data coregistered to a neurosurgical navigation system have been proposed as guides for the resection of brain tumor in or adjacent to eloquent cortices. The purpose of this study was to compare data obtained from the side of the brain affected by tumor with the contralateral side and to determine if there are physiological limitations of fMR imaging in accurately determining the location of the primary motor cortex. METHODS: Ten patients with tumors in or directly adjacent to the motor cortex were studied with fMR imaging (finger-tapping paradigm). fMR imaging data were analyzed using multiple R values. These data were coregistered to a real-time intraoperative neurosurgical navigation system. RESULTS: Significant variability of motor cortex activation patterns was noted among individual patients. The activation volumes on the side of the tumor were significantly smaller compared with the contralateral side for all tumors not previously resected (0.66±0.47). This was most pronounced in glioblastomas (0.27±0.21). We propose that these differences were caused by a loss of autoregulation in the tumor vasculature of glioblastomas and venous effects. CONCLUSION: Notwithstanding the differences noted, the motor cortex was identified successfully in all patients. This was confirmed by intraoperative physiological identification of the motor cortex and a lack of postoperative neurologic deficit. This article has been cited by other articles: J.J. Pillai The Evolution of Clinical Functional Imaging during the Past 2 Decades and Its Current Impact on Neurosurgical Planning AJNR Am. J. Neuroradiol., February 1, 2010; 31(2): 219 - 225. Abstract Full Text PDF M. Kocak, J. L. Ulmer, M. Sahin Ugurel, W. Gaggl, and R. W. Prost Motor Homunculus: Passive Mapping in Healthy Volunteers by Using Functional MR Imaging--Initial Results1 Radiology, May 1, 2009; 251(2): 485 - 492. Abstract Full Text PDF S.C. Feldman, D. Chu, M. Schulder, M. Barry, E.-S. Cho, and W.-C. Liu The Blood Oxygen Level-Dependent Functional MR Imaging Signal Can Be Used to Identify Brain Tumors and Distinguish Them from Normal Tissue AJNR Am. J. Neuroradiol., February 1, 2009; 30(2): 389 - 395. Abstract Full Text PDF C. M. Chen, B. L. Hou, and A. I. Holodny Effect of Age and Tumor Grade on BOLD Functional MR Imaging in Preoperative Assessment of Patients with Glioma Radiology, September 1, 2008; 248(3): 971 - 978. Abstract Full Text PDF A M BLAMIRE The technology of MRI -- the next 10 years? Br. J. Radiol., August 1, 2008; 81(968): 601 - 617. Abstract Full Text PDF A. Bizzi, V. Blasi, A. Falini, P. Ferroli, M. Cadioli, U. Danesi, D. Aquino, C. Marras, D. Caldiroli, and G. Broggi Presurgical Functional MR Imaging of Language and Motor Functions: Validation with Intraoperative Electrocortical Mapping Radiology, August 1, 2008; 248(2): 579 - 589. Abstract Full Text PDF I.M. Ruff, N.M. Petrovich Brennan, K.K. Peck, B.L. Hou, V. Tabar, C.W. Brennan, and A.I. Holodny Assessment of the Language Laterality Index in Patients with Brain Tumor Using Functional MR Imaging: Effects of Thresholding, Task Selection, and Prior Surgery AJNR Am. J. Neuroradiol., March 1, 2008; 29(3): 528 - 535. Abstract Full Text PDF M. Desmurget, F. Bonnetblanc, and H. Duffau Contrasting acute and slow-growing lesions: a new door to brain plasticity Brain, April 1, 2007; 130(4): 898 - 914. Abstract Full Text PDF A. Korvenoja, E. Kirveskari, H. J. Aronen, S. Avikainen, A. Brander, J. Huttunen, R. J. Ilmoniemi, J. E. Jaaskelainen, T. Kovala, J. P. Makela, et al. Sensorimotor Cortex Localization: Comparison of Magnetoencephalography, Functional MR Imaging, and Intraoperative Cortical Mapping Radiology, October 1, 2006; 241(1): 213 - 222. Abstract Full Text PDF J. R. Petrella, L. M. Shah, K. M. Harris, A. H. Friedman, T. M. George, J. H. Sampson, J. S. Pekala, and J. T. Voyvodic Preoperative Functional MR Imaging Localization of Language and Motor Areas: Effect on Therapeutic Decision Making in Patients with Potentially Resectable Brain Tumors Radiology, September 1, 2006; 240(3): 793 - 802. Abstract Full Text PDF C.V. Salvan, J.L. Ulmer, W.M. Mueller, H.G.J. Krouwer, R.W. Prost, and G.O. Stroe Presurgical and Intraoperative Mapping of the Motor System in Congenital Truncation of the Precentral Gyrus AJNR Am. J. Neuroradiol., March 1, 2006; 27(3): 493 - 497. Abstract Full Text PDF M. J.J. Kim, A. I. Holodny, B. L. Hou, K. K. Peck, C. S. Moskowitz, D. L. Bogomolny, and P. H. Gutin The Effect of Prior Surgery on Blood Oxygen Level-Dependent Functional MR Imaging in the Preoperative Assessment of Brain Tumors AJNR Am. J. Neuroradiol., September 1, 2005; 26(8): 1980 - 1985. Abstract Full Text PDF A. Krainik, M. Hund-Georgiadis, S. Zysset, and D. Y. von Cramon Regional Impairment of Cerebrovascular Reactivity and BOLD Signal in Adults After Stroke Stroke, June 1, 2005; 36(6): 1146 - 1152. Abstract Full Text PDF Y. Murata, K. Sakatani, Y. Katayama, N. Fujiwara, T. Hoshino, C. Fukaya, and T. Yamamoto Decreases of Blood Oxygenation Level--Dependent Signal in the Activated Motor Cortex during Functional Recovery after Resection of a Glioma AJNR Am. J. Neuroradiol., August 1, 2004; 25(7): 1242 - 1246. Abstract Full Text PDF A. Krainik, H. Duffau, L. Capelle, P. Cornu, A. -L. Boch, J. -F. Mangin, D. Le Bihan, C. Marsault, J. Chiras, and S. Lehericy Role of the healthy hemisphere in recovery after resection of the supplementary motor area Neurology, April 27, 2004; 62(8): 1323 - 1332. Abstract Full Text PDF J. Sailor, M. E. Meyerand, C. H. Moritz, J. Fine, L. Nelson, B. Badie, and V. M. Haughton Supplementary Motor Area Activation in Patients with Frontal Lobe Tumors and Arteriovenous Malformations AJNR Am. J. Neuroradiol., October 1, 2003; 24(9): 1837 - 1842. Abstract Full Text PDF J. L. Ulmer, H. G. Krouwer, W. M. Mueller, M.S. Ugurel, M. Kocak, and L. P. Mark Pseudo-Reorganization of Language Cortical Function at fMR Imaging: A Consequence of Tumor-Induced Neurovascular Uncoupling AJNR Am. J. Neuroradiol., February 1, 2003; 24(2): 213 - 217. Abstract Full Text PDF I D Wilkinson, C A J Romanowski, D A Jellinek, J Morris, and P D Griffiths Motor functional MRI for pre-operative and intraoperative neurosurgical guidance Br. J. Radiol., February 1, 2003; 76(902): 98 - 103. Abstract Full Text PDF Y Murata, K Sakatani, Y Katayama, and C Fukaya Increase in focal concentration of deoxyhaemoglobin during neuronal activity in cerebral ischaemic patients J. Neurol. Neurosurg. Psychiatry, August 1, 2002; 73(2): 182 - 184. Abstract Full Text PDF J. H. Brannen, B. Badie, C. H. Moritz, M. Quigley, M. E. Meyerand, and V. M. Haughton Reliability of Functional MR Imaging with Word-Generation Tasks for Mapping Broca's Area AJNR Am. J. Neuroradiol., October 1, 2001; 22(9): 1711 - 1718. Abstract Full Text PDF Home Subscribe Author Instructions Submit Online Search the AJNR Archives Feedback Help Copyright © 2010 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X

Journal

American Journal of Neuroradiology – American Journal of Neuroradiology

Published: Sep 1, 2000

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