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The developmental gene Knotted-1 is a member of a maize homeobox gene family

The developmental gene Knotted-1 is a member of a maize homeobox gene family THE Knotted-1 (Kn1) locus is defined by several dominant gain-of-function mutations that alter leaf development. Foci of cells along the lateral veins do not differentiate properly, but continue to divide, forming outpocketings or knots. The ligule, a fringe normally found at the junction of leaf blade and sheath, is often displaced and perpendicular to its normal position1–3. The phenotype is manifested in all cell layers of the leaf blade, but is controlled by a subgroup of cells of the inner layer4. Mutations result from the insertion of transposable elements5 or a tandem duplication6. We show that the Kn1 gene encodes a homeodomain-containing protein, the first identified in the plant kingdom. Sequence comparisons strongly suggest that Kn1 acts as a transcription factor. Here we use the Kn1 homeobox to isolate other expressed homeobox genes in maize. The Kn1 homeobox may permit the isolation of genes that, like animal and fungal counter-parts7, regulate cell fate determination. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

The developmental gene Knotted-1 is a member of a maize homeobox gene family

Vollbrecht, Erik; Veit, Bruce; Sinha, Neelima; Hake, Sarah
Nature , Volume 350 (6315) – Mar 21, 1991
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References (32)

Publisher
Springer Journals
Copyright
Copyright © 1991 by Nature Publishing Group
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/350241a0
Publisher site
See Article on Publisher Site

Abstract

THE Knotted-1 (Kn1) locus is defined by several dominant gain-of-function mutations that alter leaf development. Foci of cells along the lateral veins do not differentiate properly, but continue to divide, forming outpocketings or knots. The ligule, a fringe normally found at the junction of leaf blade and sheath, is often displaced and perpendicular to its normal position1–3. The phenotype is manifested in all cell layers of the leaf blade, but is controlled by a subgroup of cells of the inner layer4. Mutations result from the insertion of transposable elements5 or a tandem duplication6. We show that the Kn1 gene encodes a homeodomain-containing protein, the first identified in the plant kingdom. Sequence comparisons strongly suggest that Kn1 acts as a transcription factor. Here we use the Kn1 homeobox to isolate other expressed homeobox genes in maize. The Kn1 homeobox may permit the isolation of genes that, like animal and fungal counter-parts7, regulate cell fate determination.

Journal

Nature – Springer Journals

Published: Mar 21, 1991

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