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Measles virus (MV), a member of the family Paramyxoviridae, encodes C and V non‐structural proteins. To clarify the functions of MV C and V proteins, HeLa cell lines constitutively expressing C or V protein were established. We found that expression of V protein inhibited interferon (IFN)‐α/β signaling but not IFN‐γ signaling. C protein had no inhibitory effect on IFN signaling in our experimental condition. Degradation of selective signal transducers and activators of transcription (STAT) proteins was not observed in HeLa cells expressing V protein. In contrast, tyrosine phosphorylation of both STAT1 and STAT2 was inhibited in these cells after IFN‐β stimulation.
Febs Letters – Wiley
Published: Jun 19, 2003
Keywords: ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
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