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- Publisher
- Wiley
- Copyright
- © 2018 Wiley Periodicals, Inc.
- eISSN
- 1097-4644
- DOI
- 10.1002/jcb.26392
- pmid
- 28865131
- Publisher site
- See Article on Publisher Site
Abstract
INTRODUCTIONSpinal cord injury (SCI) is a common and crushing central nervous system (CNS) lesion which often leads to severe dysfunction of the limbs, remaining a major cause of disability. SCI gives rise to various neural cells being activated or damaged as a result of primary and secondary injury, and some neuro‐restorative strategies with positive preclinical results have been translated to the clinic, including cell therapy, neuro‐stimulation or neuro‐modulation, neurotization or nerve bridging, and neuro‐rehabilitation, and some patients have benefited from it. Cell therapy was widely used to prevent and repair the lesioned spinal cord. Autologous bone marrow‐derived mononuclear cells, human umbilical cord mesenchymal stem cells, and human Schwann cells were used to repair injured spinal cord. However, the practicality of cell therapy was limited by difficulties in obtaining cells and legal and ethical issues.Que is an important flavonoid component of various Chinese herbs, and is also found in food and vegetables. Que has been reported to exhibit anti‐oxidative, anti‐inflammatory, and anti‐carcinogenic effects. Recently, Que was confirmed to play a role in many diseases and safe for human application. Que protected against monocrotaline‐induced hepatic sinusoidal obstruction syndrome in rats, and MAPK signaling cascade is involved in this process; this reduced
Journal
Journal of Cellular Biochemistry – Wiley
Published: Feb 1, 2018
Keywords: astrocyte activation; axonal regeneration; JAK2/STAT3 signaling pathway; locomotor functional recovery; quercetin (Que); spinal cord injury (SCI)