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Int Urogynecol J (2015) 26:367–372 DOI 10.1007/s00192-014-2462-2 ORIGINAL ARTICLE Third-line treatment for overactive bladder: should mirabegron be tried before intravesical botulinum toxin A therapy? Aswini Balachandran & Natasha Curtiss & Maya Basu & Jonathan Duckett Received: 20 March 2014 /Accepted: 19 June 2014 /Published online: 17 July 2014 The International Urogynecological Association 2014 Abstract study supports mirabegron use as a third-line treatment for Introduction and hypothesis Mirabegron is a new beta 3 overactive bladder. agonist for the treatment of overactive bladder (OAB). . . Although there are extensive data from randomised con- Keywords Antimuscarinics Botulinum toxin A Detrusor . . . trolled trials, there is little real world evidence about its overactivity Mirabegron Overactive bladder Urinary effectiveness and side effects. We conducted a prospec- incontinence tive cohort study to evaluate the effectiveness of mirabegron as third-line treatment in patients with re- fractory OAB who did not benefit from antimuscarinic Introduction therapy and bladder drill. Methods The study was a prospective consecutive cohort Overactive bladder (OAB) affects 10–20 % of the adult pop- of 67 women treated with mirabegron 50 mg. All the ulation and its prevalence increases with age [1]. OAB has a patients had symptoms of urgency with
International Urogynecology Journal – Springer Journals
Published: Jul 17, 2014
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