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Take Your PIC: Motoneuronal Persistent Inward Currents May Be Somatic as Well as Dendritic. Focus on "Facilitation of Somatic Calcium Channels Can Evoke Prolonged Tail Currents in Rat Hypoglossal Motoneurons"

Take Your PIC: Motoneuronal Persistent Inward Currents May Be Somatic as Well as Dendritic. Focus... Take Your PIC: Motoneuronal Persistent Inward Currents May Be Somatic as Well as Dendritic. Focus on "Facilitation of Somatic Calcium Channels Can Evoke Prolonged Tail Currents in Rat Hypoglossal Motoneurons" Inputs to motoneurons can be amplified and prolonged by noninactivating conductances mediating "persistent inward currents" or PICs. These currents, first identified by Schwindt and Crill (1977) , are generated through voltage-dependent channels that have been thought to be confined to the membrane of the motoneuronal dendritic tree (see Heckman et al. 2003 ). In this issue of the Journal of Neurophysiology (Moritz et al. 2007 , p. 1042–1049), Binder and colleagues use nucleated patch recordings of hypoglossal motoneurons to challenge this idea. They demonstrate that some of the findings previously taken to provide evidence for dendritic localization of these channels can in fact be seen in nucleated patches—that is, in the absence of dendritic arborizations. PICs are thought to be important for regulating the gain of inputs to motoneurons (Brownstone 2006 ; Heckman et al. 2003 ). In their absence, distal dendritic inputs would have little effect on motoneuronal output (Rall 1967 ). Although motoneuronal PICs are largely mediated by dihydropyridine-sensitive (Ca V 1) calcium conductances (Hounsgaard and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurophysiology The American Physiological Society

Take Your PIC: Motoneuronal Persistent Inward Currents May Be Somatic as Well as Dendritic. Focus on "Facilitation of Somatic Calcium Channels Can Evoke Prolonged Tail Currents in Rat Hypoglossal Motoneurons"

Brownstone, Robert M.
Journal of Neurophysiology , Volume 98 (2): 579 – Aug 1, 2007
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References (35)

Publisher
The American Physiological Society
Copyright
Copyright © 2011 the American Physiological Society
ISSN
0022-3077
eISSN
1522-1598
DOI
10.1152/jn.00388.2007
pmid
17522171
Publisher site
See Article on Publisher Site

Abstract

Take Your PIC: Motoneuronal Persistent Inward Currents May Be Somatic as Well as Dendritic. Focus on "Facilitation of Somatic Calcium Channels Can Evoke Prolonged Tail Currents in Rat Hypoglossal Motoneurons" Inputs to motoneurons can be amplified and prolonged by noninactivating conductances mediating "persistent inward currents" or PICs. These currents, first identified by Schwindt and Crill (1977) , are generated through voltage-dependent channels that have been thought to be confined to the membrane of the motoneuronal dendritic tree (see Heckman et al. 2003 ). In this issue of the Journal of Neurophysiology (Moritz et al. 2007 , p. 1042–1049), Binder and colleagues use nucleated patch recordings of hypoglossal motoneurons to challenge this idea. They demonstrate that some of the findings previously taken to provide evidence for dendritic localization of these channels can in fact be seen in nucleated patches—that is, in the absence of dendritic arborizations. PICs are thought to be important for regulating the gain of inputs to motoneurons (Brownstone 2006 ; Heckman et al. 2003 ). In their absence, distal dendritic inputs would have little effect on motoneuronal output (Rall 1967 ). Although motoneuronal PICs are largely mediated by dihydropyridine-sensitive (Ca V 1) calcium conductances (Hounsgaard and

Journal

Journal of Neurophysiology – The American Physiological Society

Published: Aug 1, 2007

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