Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

p50/YB-1, a Major Protein of Cytoplasmic mRNPs, Regulates Its Own Synthesis

p50/YB-1, a Major Protein of Cytoplasmic mRNPs, Regulates Its Own Synthesis Doklady Biochemistry and Biophysics, Vol. 395, 2004, pp. 93–95. Translated from Doklady Akademii Nauk, Vol. 395, No. 4, 2004, pp. 548–550. Original Russian Text Copyright © 2004 by Skabkina, Skabkin, Lyabin, Ovchinnikov. BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY p50/YB-1, a Major Protein of Cytoplasmic mRNPs, Regulates Its Own Synthesis 1 1,2 1 1 O. V. Skabkina , M. A. Skabkin , D. N. Lyabin , and Academician L. P. Ovchinnikov Received November 11, 2003 Mammalian protein p50 (also known as YB-1, ing the required of mRNA activity in translation. We dbpB, MSY-1, and EF1A) is a member of the multi- suggested that the p50, specifically binding with the functional family of DNA/RNA-binding proteins with noncoding region of its mRNA near the PABP-binding an evolutionarily conserved cold-shock domain [1]. site, may inhibit its own synthesis by displacing PABP Prokaryotic representatives of this protein family, from the specific complex with mRNA. termed the major cold-shock proteins, are actively syn- The purpose of this work was to verify the above thesized in bacterial cells upon temperature decrease suggestion. In this study, we showed that p50 may com- and general suppression of protein synthesis,—and pletely inhibit its own synthesis, without inhibiting the ensure adaptation http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Doklady Biochemistry and Biophysics Springer Journals

p50/YB-1, a Major Protein of Cytoplasmic mRNPs, Regulates Its Own Synthesis

Download PDF
3 pages

Loading next page...
 
/lp/springer-journals/p50-yb-1-a-major-protein-of-cytoplasmic-mrnps-regulates-its-own-SmObhUG091

References (14)

Publisher
Springer Journals
Copyright
Copyright © 2004 by MAIK “Nauka/Interperiodica”
Subject
Life Sciences; Biochemistry, general; Biological and Medical Physics, Biophysics
ISSN
1607-6729
eISSN
1608-3091
DOI
10.1023/B:DOBI.0000025554.28703.bf
Publisher site
See Article on Publisher Site

Abstract

Doklady Biochemistry and Biophysics, Vol. 395, 2004, pp. 93–95. Translated from Doklady Akademii Nauk, Vol. 395, No. 4, 2004, pp. 548–550. Original Russian Text Copyright © 2004 by Skabkina, Skabkin, Lyabin, Ovchinnikov. BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY p50/YB-1, a Major Protein of Cytoplasmic mRNPs, Regulates Its Own Synthesis 1 1,2 1 1 O. V. Skabkina , M. A. Skabkin , D. N. Lyabin , and Academician L. P. Ovchinnikov Received November 11, 2003 Mammalian protein p50 (also known as YB-1, ing the required of mRNA activity in translation. We dbpB, MSY-1, and EF1A) is a member of the multi- suggested that the p50, specifically binding with the functional family of DNA/RNA-binding proteins with noncoding region of its mRNA near the PABP-binding an evolutionarily conserved cold-shock domain [1]. site, may inhibit its own synthesis by displacing PABP Prokaryotic representatives of this protein family, from the specific complex with mRNA. termed the major cold-shock proteins, are actively syn- The purpose of this work was to verify the above thesized in bacterial cells upon temperature decrease suggestion. In this study, we showed that p50 may com- and general suppression of protein synthesis,—and pletely inhibit its own synthesis, without inhibiting the ensure adaptation

Journal

Doklady Biochemistry and Biophysics – Springer Journals

Published: Oct 18, 2004

There are no references for this article.