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Reply Reply Dr Russo is correct to highlight the limitations of the standard measurement site – 4% of the ulnar length – for cortical density assessment. However, the aim of our clinical study was not to optimize the accuracy of the measurement, but to use measurement values obtained from standard procedures. The clinical usefulness of a diagnostic method should not rely on its capacity to distinguish between osteoporotic patients and healthy individuals, but on its predictive ability to assess future fracture risk. In our paper, we emphasized that pQCT has been found to be successful in distinguishing between osteoporotic and non‐osteoporotic subjects, but prospective data of radial BMD as measured by pQCT and fracture incidence do not yet exist. Until the ability of pQCT to predict future fracture occurrence has been demonstrated, current evidence does not allow it to be recommended as a standard diagnostic tool in older women. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Internal Medicine Wiley

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Boonen, S.
Journal of Internal Medicine , Volume 244 (4) – Oct 1, 1998
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Publisher
Wiley
Copyright
Blackwell Science Ltd, 1997
ISSN
0954-6820
eISSN
1365-2796
DOI
10.1046/j.1365-2796.1998.00420.x
Publisher site
See Article on Publisher Site

Abstract

Reply Dr Russo is correct to highlight the limitations of the standard measurement site – 4% of the ulnar length – for cortical density assessment. However, the aim of our clinical study was not to optimize the accuracy of the measurement, but to use measurement values obtained from standard procedures. The clinical usefulness of a diagnostic method should not rely on its capacity to distinguish between osteoporotic patients and healthy individuals, but on its predictive ability to assess future fracture risk. In our paper, we emphasized that pQCT has been found to be successful in distinguishing between osteoporotic and non‐osteoporotic subjects, but prospective data of radial BMD as measured by pQCT and fracture incidence do not yet exist. Until the ability of pQCT to predict future fracture occurrence has been demonstrated, current evidence does not allow it to be recommended as a standard diagnostic tool in older women.

Journal

Journal of Internal Medicine – Wiley

Published: Oct 1, 1998

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