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Hormonal profiles in the follicular phase, luteal phase and first trimester of pregnancies arising from in‐vitro fertilization

Hormonal profiles in the follicular phase, luteal phase and first trimester of pregnancies... Summary. The hormonal profiles for oestradiol‐17β, progesterone, prolactin and β‐human chorionic gonadotrophin (β‐hCG) are documented for the first 24 pregnancies arising from in‐vitro fertilization during a collaborative project between the University of Western Australia and PIVET Laboratory. All patients had ovarian follicle stimulation with clomiphene citrate, sometimes combined with human menopausal gonadotrophin and all had oocyte recovery undertaken 36 h after injection o f 5000 i.u. hCG. The follicular phase profile indicated that patients were admitted for the hCG injection when oestradiol‐17β levels were around 1500 pmol/l per follicle with a dimension of 1·6 cm on ultrasound. Luteal phase data indicated that oestradiol‐17β and progesterone levels were two to three times higher than that expected during spontaneous conception cycles and those pregnancies which subsequently aborted had significantly lower levels in the late luteal phase. During pregnancy elevated oestradiol‐17β and progesterone levels were maintained through the early weeks during organogenesis while the β‐hCG profile was similar to that reported for spontaneous pregnancies arising without ovarian stimulation. Six women aborted and the other 18 pregnancies have generated 22 infants. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png BJOG : An International Journal of Obstetrics & Gynaecology Wiley

Hormonal profiles in the follicular phase, luteal phase and first trimester of pregnancies arising from in‐vitro fertilization

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References (42)

Publisher
Wiley
Copyright
"Copyright © 1985 Wiley Subscription Services, Inc., A Wiley Company"
ISSN
1470-0328
eISSN
1471-0528
DOI
10.1111/j.1471-0528.1985.tb01112.x
Publisher site
See Article on Publisher Site

Abstract

Summary. The hormonal profiles for oestradiol‐17β, progesterone, prolactin and β‐human chorionic gonadotrophin (β‐hCG) are documented for the first 24 pregnancies arising from in‐vitro fertilization during a collaborative project between the University of Western Australia and PIVET Laboratory. All patients had ovarian follicle stimulation with clomiphene citrate, sometimes combined with human menopausal gonadotrophin and all had oocyte recovery undertaken 36 h after injection o f 5000 i.u. hCG. The follicular phase profile indicated that patients were admitted for the hCG injection when oestradiol‐17β levels were around 1500 pmol/l per follicle with a dimension of 1·6 cm on ultrasound. Luteal phase data indicated that oestradiol‐17β and progesterone levels were two to three times higher than that expected during spontaneous conception cycles and those pregnancies which subsequently aborted had significantly lower levels in the late luteal phase. During pregnancy elevated oestradiol‐17β and progesterone levels were maintained through the early weeks during organogenesis while the β‐hCG profile was similar to that reported for spontaneous pregnancies arising without ovarian stimulation. Six women aborted and the other 18 pregnancies have generated 22 infants.

Journal

BJOG : An International Journal of Obstetrics & Gynaecology – Wiley

Published: Apr 1, 1985

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