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H. Christofk, M. Heiden, M. Harris, A. Ramanathan, R. Gerszten, Ru Wei, M. Fleming, S. Schreiber, L. Cantley (2008)
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growthNature, 452
D. Izyumov, A. Avetisyan, O. Pletjushkina, D. Sakharov, K. Wirtz, B. Chernyak, V. Skulachev (2004)
"Wages of fear": transient threefold decrease in intracellular ATP level imposes apoptosis.Biochimica et biophysica acta, 1658 1-2
M. Selak, S. Armour, Elaine MacKenzie, Houda Boulahbel, D. Watson, K. Mansfield, Yi Pan, M. Simon, C. Thompson, E. Gottlieb (2005)
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylaseCancer Cell, 7
R. Gatenby, R. Gillies (2004)
Why do cancers have high aerobic glycolysis?Nature Reviews Cancer, 4
M. Heiden, N. Chandel, P. Schumacker, C. Thompson, C. Thompson (1999)
Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange.Molecular cell, 3 2
R. Moreno-Sánchez, S. Rodríguez-Enríquez, Álvaro Marín-Hernández, E. Saavedra (2007)
Energy metabolism in tumor cellsThe FEBS Journal, 274
F. Bleeker, S. Lamba, S. Leenstra, D. Troost, T. Hulsebos, W. Vandertop, M. Frattini, F. Molinari, M. Knowles, A. Cerrato, M. Rodolfo, A. Scarpa, L. Felicioni, F. Buttitta, S. Malatesta, A. Marchetti, A. Bardelli (2009)
IDH1 mutations at residue p.R132 (IDH1R132) occur frequently in high‐grade gliomas but not in other solid tumorsHuman Mutation, 30
E. Calle, R. Kaaks (2004)
Overweight, obesity and cancer: epidemiological evidence and proposed mechanismsNature Reviews Cancer, 4
M. Buzzai, D. Bauer, Russell Jones, R. Deberardinis, G. Hatzivassiliou, R. Elstrom, C. Thompson (2005)
The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid β-oxidationOncogene, 24
H. Christofk, M. Heiden, Ning Wu, J. Asara, L. Cantley (2008)
Pyruvate kinase M2 is a phosphotyrosine-binding proteinNature, 452
P. Gao, Irina Tchernyshyov, Tsung-Cheng Chang, Yun‐Sil Lee, Kayoko Kita, T. Ochi, K. Zeller, A. Marzo, J. Eyk, J. Mendell, C. Dang (2009)
c-Myc suppression of miR-23 enhances mitochondrial glutaminase and glutamine metabolismNature, 458
(1976)
Krebsforsch. Klin. Onkol
S. Weinhouse (2004)
The Warburg hypothesis fifty years laterZeitschrift für Krebsforschung und Klinische Onkologie, 87
M. Serrano, Athena Lin, M. McCurrach, D. Beach, S. Lowe (1997)
Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4aCell, 88
C. Thompson (2009)
Metabolic enzymes as oncogenes or tumor suppressors.The New England journal of medicine, 360 8
M. Yuneva, Nicola Zamboni, P. Oefner, R. Sachidanandam, Y. Lazebnik (2007)
Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cellsThe Journal of Cell Biology, 178
S. Gottschalk, N. Anderson, Carsten Hainz, S. Eckhardt, N. Serkova, N. Serkova (2004)
Imatinib (STI571)-Mediated Changes in Glucose Metabolism in Human Leukemia BCR-ABL-Positive CellsClinical Cancer Research, 10
D. Parsons, Siân Jones, Xiaosong Zhang, Jimmy Lin, R. Leary, P. Angenendt, P. Mankoo, H. Carter, I. Siu, G. Gallia, A. Olivi, R. McLendon, B. Rasheed, S. Keir, T. Nikolskaya, Y. Nikolsky, D. Busam, H. Tekleab, L. Diaz, James Hartigan, Douglas Smith, R. Strausberg, S. Marie, S. Shinjo, Hai Yan, G. Riggins, D. Bigner, R. Karchin, N. Papadopoulos, G. Parmigiani, B. Vogelstein, V. Velculescu, K. Kinzler (2008)
An Integrated Genomic Analysis of Human Glioblastoma MultiformeScience, 321
R. Deberardinis, J. Lum, G. Hatzivassiliou, C. Thompson (2008)
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.Cell metabolism, 7 1
(2005)
Cancer Cell 2005;7:77
B. Baysal, R. Ferrell, J. Willett-Brozick, E. Lawrence, D. Myssiorek, A. Bosch, A. Mey, P. Taschner, W. Rubinstein, E. Myers, C. Richard, C. Cornelisse, P. Devilee, B. Devlin (2000)
Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma.Science, 287 5454
P. Sonveaux, F. Végran, Thies Schroeder, M. Wergin, J. Verrax, Z. Rabbani, Christophe Saedeleer, Kelly Kennedy, C. Diepart, B. Jordan, M. Kelley, B. Gallez, M. Wahl, O. Féron, M. Dewhirst (2008)
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.The Journal of clinical investigation, 118 12
David Wise, R. Deberardinis, A. Mancuso, Nabil Sayed, Xiao-yong Zhang, H. Pfeiffer, I. Nissim, E. Daikhin, M. Yudkoff, S. McMahon, C. Thompson (2008)
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addictionProceedings of the National Academy of Sciences, 105
D. Granot, M. Snyder (1991)
Glucose induces cAMP-independent growth-related changes in stationary-phase cells of Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America, 88
Richard Shaw (2004)
Inaugural Article: The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stressProceedings of the National Academy of Sciences of the United States of America
Hai Yan, D. Parsons, Geng-lin Jin, R. McLendon, B. Rasheed, Weishi Yuan, I. Kos, I. Batinic-Haberle, Siân Jones, G. Riggins, H. Friedman, A. Friedman, D. Reardon, J. Herndon, Kenneth Kinzler, V. Velculescu, B. Vogelstein, D. Bigner (2009)
IDH1 and IDH2 mutations in gliomas.The New England journal of medicine, 360 8
M. El‐Maghrabi, S. Pilkis (1984)
Rat liver 6‐phosphofructo 2‐kinase/ fructose 2,6‐bisphosphatase: A review of relationships between the two activities of the enzymeJournal of Cellular Biochemistry, 26
(2004)
Page 7 Science. Author manuscript; available in PMC 2010 April 5. N IH -P A A u th o r M a n u s c ip t N IH -P A A u th o r M a n u s c ip t N IH -P A A u th o r M a n u s c ip t
O. Warburg (1956)
[Origin of cancer cells].Oncologia, 9 2
S. Ben-Haim, P. Ell (2008)
18F-FDG PET and PET/CT in the Evaluation of Cancer Treatment Response*Journal of Nuclear Medicine, 50
Peggy Hsu, D. Sabatini (2008)
Cancer Cell Metabolism: Warburg and BeyondCell, 134
H. Kondoh, M. Lleonart, Yasuhiro Nakashima, M. Yokode, Makoto Tanaka, D. Bernard, J. Gil, D. Beach (2006)
A high glycolytic flux supports the proliferative potential of murine embryonic stem cells.Antioxidants & redox signaling, 9 3
R. Deberardinis, A. Mancuso, E. Daikhin, I. Nissim, M. Yudkoff, S. Wehrli, C. Thompson (2007)
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesisProceedings of the National Academy of Sciences, 104
(2008)
Cell Metab 2008;7:11
A. Lehninger (1984)
Principles of Biochemistry
M. Heiden, D. Plas, J. Rathmell, C. Fox, M. Harris, C. Thompson (2001)
Growth Factors Can Influence Cell Growth and Survival through Effects on Glucose MetabolismMolecular and Cellular Biology, 21
J. Evans, L. Donnelly, A. Emslie-Smith, D. Alessi, A. Morris (2005)
Metformin and reduced risk of cancer in diabetic patientsBMJ : British Medical Journal, 330
(2007)
Antioxid Redox Signal 2007;9:293
R. Elstrom, D. Bauer, M. Buzzai, Robyn Karnauskas, M. Harris, D. Plas, H. Zhuang, Ryan Cinalli, A. Alavi, C. Rudin, C. Thompson (2004)
Akt Stimulates Aerobic Glycolysis in Cancer CellsCancer Research, 64
K. Nolop, C. Rhodes, L. Brudin, R. Beaney, T. Krausz, T. Jones, J. Hughes (1987)
Glucose utilization in vivo by human pulmonary neoplasmsCancer, 60
F. Chiaradonna, Elena Sacco, R. Manzoni, M. Giorgio, Marco Vanoni, L. Alberghina (2006)
Ras-dependent carbon metabolism and transformation in mouse fibroblastsOncogene, 25
Patrick Pollard, N. Wortham, I. Tomlinson (2003)
The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenaseAnnals of Medicine, 35
J. Lum, D. Bauer, M. Kong, M. Harris, Chi Li, T. Lindsten, C. Thompson (2005)
Growth Factor Regulation of Autophagy and Cell Survival in the Absence of ApoptosisCell, 120
D. Hardie (2007)
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energyNature Reviews Molecular Cell Biology, 8
Zheng Chen, Elizabeth Odstrcil, B. Tu, S. McKnight (2007)
Restriction of DNA Replication to the Reductive Phase of the Metabolic Cycle Protects Genome IntegrityScience, 316
G. Hatzivassiliou, F. Zhao, D. Bauer, C. Andreadis, A. Shaw, D. Dhanak, S. Hingorani, D. Tuveson, C. Thompson (2005)
ATP citrate lyase inhibition can suppress tumor cell growth.Cancer cell, 8 4
M. Pollak (2008)
Insulin and insulin-like growth factor signalling in neoplasiaNature Reviews Cancer, 8
V. Fantin, J. St-Pierre, P. Leder (2006)
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance.Cancer cell, 9 6
J. Engelman, Liang Chen, X. Tan, K. Crosby, A. Guimaraes, Rabi Upadhyay, Michel Maira, K. McNamara, Samanthi Perera, Youngchul Song, L. Chirieac, R. Kaur, Angela Lightbown, Jessica Simendinger, Timothy Li, R. Padera, C. García-echeverría, R. Weissleder, U. Mahmood, L. Cantley, Kwok-kin Wong (2008)
Effective Use of PI3K and MEK Inhibitors to Treat Mutant K-Ras G12D and PIK3CA H1047R Murine Lung CancersNature medicine, 14
K. Bensaad, A. Tsuruta, M. Selak, M. Vidal, K. Nakano, R. Bartrons, E. Gottlieb, K. Vousden (2006)
TIGAR, a p53-Inducible Regulator of Glycolysis and ApoptosisCell, 126
(2005)
Oncogene 2005;24:4165
We thank A. Van den Abbeele (Department of Imaging, Dana-Farber Cancer Institute, Boston) for the FDG-PET image
Science – Unpaywall
Published: May 21, 2009
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